Cellular responses to DNA damage

DNA Repair and Mutagenesis

2006 • 4,725 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.

1996 • 851 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Regulation of RAD53 by the ATM -Like Kinases MEC1 and TEL1 in Yeast Cell Cycle Checkpoint Pathways

1996 • 593 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1997 • 541 citations

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

1995 • 540 citations

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

1996 • 502 citations

Interaction between ATM protein and c-Abl in response to DNA damage

1997 • 481 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage Checkpoint

1996 • 397 citations

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

1997 • 392 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast

1994 • 344 citations

Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport

1996 • 309 citations

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways.

1996 • 307 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1996 • 282 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Repression of p53-mediated transcription by MDM2: a dual mechanism

1997 • 272 citations

Functional interaction between DNA-PK and c-Abl in response to DNA damage

1997 • 254 citations

Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

1996 • 220 citations

p53; from inductive signal to cellular effect

1997 • 214 citations

The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.

1996 • 196 citations

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

1997 • 191 citations

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1997 • 160 citations

Phosphorylation of the C-terminal domain of RNA polymerase II

1995 • 133 citations

Abrogation of Retinoblastoma Protein Function by c-Abl through Tyrosine Kinase-Dependent and -Independent Mechanisms

1995 • 80 citations

Tyrosine Phosphorylation of RNA Polymerase II Carboxyl-terminal Domain by the Abl-related Gene Product

1997 • 69 citations

From DNA damage to cell cycle arrest and suicide: a budding yeast perspective

1996 • 65 citations

Identification of a Binding Site in c-Abl Tyrosine Kinase for the C-Terminal Repeated Domain of RNA Polymerase II

1996 • 65 citations