Fas and Fas Ligand Expression in Fetal and Adult Human Testis with Normal or Deranged Spermatogenesis

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1987 • 64,270 citations

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1960 • 10,428 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The Fas Death Factor

1995 • 4,070 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function

1991 • 602 citations

An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis

1997 • 599 citations

Potential Involvement of Fas and Its Ligand in the Pathogenesis of Hashimoto's Thyroiditis

1997 • 584 citations

The Fas System Is a Key Regulator of Germ Cell Apoptosis in the Testis*

1997 • 515 citations

Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.

1996 • 464 citations

Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages.

1995 • 371 citations

Ultrastructure and function of the Sertoli cell

1975 • 320 citations

Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors.

1993 • 300 citations

Mammalian cytoplasmic actins are the products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins

1978 • 294 citations

The Fas System, a Regulator of Testicular Germ Cell Apoptosis, Is Differentially Up-Regulated in Sertoli Cell Versus Germ Cell Injury of the Testis*

1999 • 284 citations

Testicular degeneration in Bclw-deficient mice

1998 • 263 citations

The meiotic checkpoint monitoring sypapsis eliminates spermatocytes via p53-independent apoptosis

1998 • 259 citations

Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia

1996 • 258 citations

Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment.

1995 • 240 citations

Role of Fas Ligand in Apoptosis Induced by Hepatitis C Virus Infection

1994 • 180 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

Fas regulates germ cell apoptosis in the human testis in vitro

1999 • 176 citations

Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult.

1997 • 168 citations

Effects of Chemotherapy and Radiotherapy on Spermatogenesis

1993 • 167 citations

Spontaneous Germ Cell Apoptosis in Humans: Evidence for Ethnic Differences in the Susceptibility of Germ Cells to Programmed Cell Death

1998 • 163 citations

Testis-derived Sertoli cells survive and provide localized immunoprotection for xenografts in rat brain

1996 • 150 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

Germ Cell Apoptosis in the Testes of Sprague Dawley Rats Following Testosterone Withdrawal by Ethane 1,2-Dimethanesulfonate Administration: Relationship to Fas?1

1999 • 135 citations

Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp70-2 knockout mice

1997 • 130 citations

In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis

1997 • 126 citations

A matter of death and life: the significance of germ cell death during spermatogenesis

1998 • 117 citations

PCR In Situ Hybridization

2003 • 114 citations

Apoptosis and Spermatogenesis: Evidence from an in Vivo Model of Testosterone Withdrawal in the Adult Rat

1994 • 108 citations

Testosterone Regulates Apoptosis in Adult Human Seminiferous Tubulesin Vitro¹

1997 • 105 citations

Fate of Germ Cells in 2,5-Hexanedione-Induced Testicular Injury

1996 • 98 citations

Fas ligand, Fas antigen and Bcl-2 expression in human endometrium during the menstrual cycle

1999 • 96 citations

Quantitation of the cells of the seminiferous epithelium of the human testis employing the Sertoli cell as a constant

1971 • 92 citations

Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat.

1996 • 89 citations

Fas (APO-1, CD95)-Mediated Apoptosis in Thyroid Cells Is Regulated by a Labile Protein Inhibitor*

1997 • 84 citations

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

1994 • 81 citations

In‐situ quantification of stage‐specific apoptosis in the rat seminiferous epithelium: effects of short‐term experimental cryptorchidism

1995 • 79 citations

Fate of Germ Cells in 2,5-Hexanedione-Induced Testicular Injury

1996 • 79 citations

Expression of Fas and Fas ligand in the testes and testicular germ cell tumors: an immunohistochemical study.

1998 • 77 citations

Constitutive Fas Ligand Gene Transcription in Sertoli Cells Is Regulated By Sp1

1999 • 76 citations

Stage‐Specific Apoptosis in the Rat Seminiferous Epithelium: Quantification of Irradiation Effects

1996 • 63 citations

Apoptosis pattern elicited by oestradiol treatment of the seminiferous epithelium of the adult rat

1997 • 61 citations

Apoptosis as a mechanism of germ cell loss in elderly men

1997 • 60 citations

Expression of the FSH Receptor in the Testis

1993 • 59 citations

In-situ polymerase chain reaction: foundation of the technology and today's options.

1998 • 29 citations