Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus
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References (42)
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
2006 • 1,803 citations
The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors
2002 • 1,478 citations
Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
2010 • 1,163 citations
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
2009 • 1,067 citations
The Pathology of Influenza Virus Infections
2008 • 1,019 citations
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus
2007 • 933 citations
Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections
2009 • 714 citations
The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus
2009 • 578 citations
A question of self‐preservation: immunopathology in influenza virus infection
2007 • 455 citations
CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality
2008 • 441 citations
2009 Pandemic Influenza A (H1N1)
2010 • 412 citations
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
2010 • 391 citations
Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
2009 • 355 citations
Pathology of human influenza revisited
2008 • 347 citations
Symptom pathogenesis during acute influenza: Interleukin‐6 and Other cytokine responses
2001 • 340 citations
Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus
2008 • 295 citations
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation
2008 • 272 citations
Cytokine Kinetics and Other Host Factors in Response to Pneumococcal Pulmonary Infection in Mice
1998 • 235 citations
Cytokine dysregulation as a mechanism of graft versus host disease
1993 • 229 citations
The role of MIP-1α in Inflammation and hematopoiesis
1996 • 218 citations
Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes
2009 • 209 citations
Immunomodulatory Properties of Interferon‐γ: An Updatea
1998 • 179 citations
Interferon and cytokine responses to SARS-coronavirus infection
2008 • 154 citations
The cytokine storm in multiple sclerosis
1998 • 153 citations
S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species
2009 • 138 citations
Molecular Inflammatory Responses Measured in Blood of Patients with Severe Community-Acquired Pneumonia
2003 • 132 citations
Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis
1997 • 131 citations
A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection
2009 • 120 citations
Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages
2004 • 108 citations
Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation
2010 • 98 citations
Role of Host Immune Response and Viral Load in the Differential Outcome of Pandemic H1N1 (2009) Influenza Virus Infection in Indian Patients
2010 • 87 citations
Therapeutic Effect of Anti-Macrophage Inflammatory Protein 2 Antibody on Influenza Virus-Induced Pneumonia in Mice
2000 • 82 citations
A rationale for using steroids in the treatment of severe cases of H5N1 avian influenza
2007 • 71 citations
Modulating tone: the overture of S1P receptor immunotherapeutics
2008 • 69 citations
Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza
2008 • 66 citations
Hantavirus cardiopulmonary syndrome: immune response and pathogenesis
2006 • 64 citations
Treatment options for 2009 H1N1 influenza: evaluation of the published evidence
2010 • 63 citations
Recent developments in the management of haemophagocytic lymphohistiocytosis
2001 • 50 citations
Interferons and Viruses: Signaling for Supremacy
2006 • 41 citations
Rapid Detection of Reassortment of Pandemic H1N1/2009 Influenza Virus
2010 • 28 citations
Update on oseltamivir-resistant pandemic A (H1N1) 2009 influenza virus: January 2010.
2009 • 24 citations
Pandemic influenza A (H1N1) virus infection and avian influenza A (H5N1) virus infection: a comparative analysisThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.
2010 • 23 citations