Detection of altered T helper 1 and T helper 2 cytokine production by peripheral blood mononuclear cells in patients with multiple sclerosis utilizing intracellular cytokine detection by flow cytometry and surface marker analysis

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases

1995 • 1,120 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Perturbation of vesicular traffic with the carboxylic ionophore monensin

1983 • 890 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure

1991 • 465 citations

Cytokine regulation of T-cell function: potential for therapeutic intervention

1993 • 412 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

Interferon β decreases T cell activation and interferon γ production in multiple sclerosis

1993 • 264 citations

MS: a CNS and systematic autoimmune disease

1989 • 231 citations

Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.

1995 • 168 citations

Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis.

1995 • 166 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Interferons in Multiple Sclerosis

1992 • 104 citations

Interferon effects on interleukin-10 secretion Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients

1995 • 103 citations

Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients

1995 • 88 citations

Isolation of encephalitogenic CD4+ T cell clones in the rat

1989 • 78 citations

Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis

1995 • 68 citations

Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis

1993 • 66 citations

Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis

1989 • 63 citations

Cytokine production by peripheral blood monocytes/macrophages in multiple sclerosis patients

1993 • 60 citations

Contrasting effects of alpha, beta, and gamma interferons on nonspecific suppressor function in multiple sclerosis

1992 • 44 citations

T Cell Lymphokine-Induced Secretion of Cytokines by Monocytes from Patients with Multiple Sclerosis

1993 • 22 citations

Expression of monocyte activation antigen Mo3 on the surface of peripheral blood monocytes from patients with multiple sclerosis

1992 • 20 citations

Alterations in peripheral blood mononuclear cell cytokine production in response to phytohemagglutinin in multiple sclerosis patients

1995 • 19 citations

Advances in specific therapy for multiple sclerosis

1994 • 18 citations

Detection of intracellular interleukin-10 by flow cytometry

1992 • 14 citations

T and B cell responses to myelin basic protein and encephalitogenic epitopes

1993 • 13 citations

Systemic lymphoblastoid interferon therapy in chronic progressive multiple sclerosis. II. Immunologic evaluation

1991 • 10 citations

T lymphocyte populations in multiple sclerosis

1985 • 3 citations