Inhibition of Contraction and Myosin Light Chain Phosphorylation in Guinea‐Pig Smooth Muscle by p21‐Activated Kinase 1

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Ca2+-induced hydrophobic site on calmodulin: Application for purification of calmodulin by phenyl-Sepharose affinity chromatography

1982 • 877 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

Expression of Constitutively Active α-PAK Reveals Effects of the Kinase on Actin and Focal Complexes

1997 • 560 citations

Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase

1999 • 522 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

1999 • 380 citations

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

1998 • 356 citations

Invited Review: Regulation of myosin phosphorylation in smooth muscle

2001 • 304 citations

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1998 • 296 citations

Cyclic GMP Causes Ca2+ Desensitization in Vascular Smooth Muscle by Activating the Myosin Light Chain Phosphatase

1997 • 263 citations

Myosin light chain kinases.

1997 • 247 citations

The Mechanism of PAK Activation

2001 • 243 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Expression of CPI‐17 and myosin phosphatase correlates with Ca²⁺ sensitivity of protein kinase C‐induced contraction in rabbit smooth muscle

2001 • 238 citations

Phosphorylation of the myosin phosphatase targeting subunit and CPI‐17 during Ca²⁺ Sensitization in Rabbit Smooth Muscle

2003 • 223 citations

A Drosophila Homolog of the Rac- and Cdc42-Activated Serine/Threonine Kinase PAK Is a Potential Focal Adhesion and Focal Complex Protein That Colocalizes with Dynamic Actin Structures

1996 • 204 citations

Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A

1999 • 201 citations

Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

1998 • 199 citations

A novel mechanism for the Ca(2+)-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase.

1994 • 182 citations

PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells

2002 • 165 citations

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

2000 • 146 citations

Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle

1998 • 143 citations

Regulation of vascular smooth muscle tone by caldesmon.

1992 • 134 citations

Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II

2000 • 132 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

AR and ER Interaction with a p21-Activated Kinase (PAK6)

2002 • 128 citations

Agonist-induced changes in the phosphorylation of the myosin- binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle

2002 • 117 citations

Caldesmon inhibits skeletal actomyosin subfragment-1 ATPase activity and the binding of myosin subfragment-1 to actin.

1987 • 104 citations

Angiotensin II Stimulates p21-Activated Kinase in Vascular Smooth Muscle Cells

1998 • 89 citations

p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK

2001 • 89 citations

Cloning and Characterization of a Dictyostelium Myosin I Heavy Chain Kinase Activated by Cdc42 and Rac

1996 • 88 citations

Phosphorylation of Caldesmon by p21-activated Kinase

2000 • 86 citations

Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase

2002 • 83 citations

Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins

1998 • 79 citations

Angiotensin II-induced Stimulation of p21-activated Kinase and c-Jun NH2-terminal Kinase Is Mediated by Rac1 and Nck

2001 • 63 citations

Ion-specific and general ionic effects on contraction of skinned fast-twitch skeletal muscle from the rabbit.

1991 • 56 citations

Caldesmon and a 20-kDa actin-binding fragment of caldesmon inhibit tension development in skinned gizzard muscle fiber bundles.

1993 • 54 citations

Regulation of cross-bridge cycling by Ca2+ in smooth muscle

1999 • 51 citations

Myosin light chain and caldesmon phosphorylation in arterial muscle stimulated with endothelin-1

1990 • 49 citations

Regulation by GDI of RhoA/Rho-kinase-induced Ca²⁺sensitization of smooth muscle myosin II

2001 • 39 citations

Exogenous caldesmon promotes relaxation of guinea-pig skinned taenia coli smooth muscles: inhibition of cooperative reattachment of latch bridges?

1997 • 34 citations

Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2

1989 • 33 citations

The effects of caldesmon extraction on mechanical properties of skinned smooth muscle fibre preparations

1996 • 31 citations

Thiophosphorylation‐induced Ca²⁺ sensitization of guinea‐pig ileum contractility is not mediated by Rho‐associated kinase

2001 • 22 citations

Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle.

1991 • 21 citations

Differential Skinning of Smooth Muscle: A New Approach to Excitation-Contraction Coupling

1991 • 19 citations