A Drosophila Homolog of the Rac- and Cdc42-Activated Serine/Threonine Kinase PAK Is a Potential Focal Adhesion and Focal Complex Protein That Colocalizes with Dynamic Actin Structures

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The embryonic development of Drosophila melanogaster

1938 • 2,188 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system

1988 • 1,235 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Drosophila: a laboratory manual

1990 • 1,081 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Cytoskeleton—Plasma Membrane Interactions

1992 • 792 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 725 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

Functional cDNA libraries from Drosophila embryos

1988 • 604 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.

1994 • 469 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function.

1993 • 424 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

1995 • 357 citations

Signalling through SH2 and SH3 domains

1993 • 355 citations

hemipterous encodes a novel drosophila MAP kinase kinase, required for epithelial cell sheet movement

1995 • 331 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Pioneer growth cone steering decisions mediated by single filopodial contacts in situ

1990 • 268 citations

Navigational errors made by growth cones without filopodia in the embryonic xenopus brain

1993 • 264 citations

The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachments

1987 • 263 citations

Cytoplasmic myosin from Drosophila melanogaster.

1986 • 256 citations

The function of PS integrins during Drosophila embryogenesis

1989 • 256 citations

Drosophila: A laboratory manual

1990 • 245 citations

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.

1985 • 218 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway

1995 • 209 citations

A role for integrin in the formation of sarcomeric cytoarchitecture

1990 • 207 citations

Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24

1995 • 192 citations

CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium.

1995 • 190 citations

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.

1993 • 189 citations

Drosophila Extracellular Matrix

1989 • 181 citations

Tiggrin, a novel Drosophila extracellular matrix protein that functions as a ligand for Drosophila αPS2βPS integrins

1994 • 170 citations

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

1995 • 170 citations

A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila

1995 • 169 citations

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 • 166 citations

Growth cone behavior and production of traction force.

1990 • 166 citations

Distribution of F-actin during cleavage of the Drosophila syncytial blastoderm.

1984 • 120 citations

puckered, a gene involved in position-specific cell differentiation in the dorsal epidermis of the Drosophila larva

1993 • 119 citations

Paxillin is a major phosphotyrosine-containing protein during embryonic development.

1991 • 119 citations

Characterization of rho GTPase family homologues in Drosophila melanogaster: overexpressing Rho1 in retinal cells causes a late developmental defect.

1995 • 113 citations

Drosophila spectrin: the membrane skeleton during embryogenesis.

1989 • 109 citations

Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes

1995 • 98 citations

Integrins hold Drosophila together

1993 • 97 citations

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1992 • 76 citations

Drosophila integrins and their ligands

1994 • 64 citations

Differentiation, extracellular matrix synthesis, and integrin assembly by Drosophila embryo cells cultured on vitronectin and laminin substrates

1994 • 41 citations

Functional Properties of Alternatively Spliced Forms of theDrosophilaPS2 Integrin α Subunit

1993 • 40 citations

Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhabditis elegans.

1994 • 24 citations