Back and forth

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

Purification and properties

1975 • 1,733 citations

Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions

1974 • 1,362 citations

Lipid Asymmetry in Membranes

1979 • 1,245 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement

1993 • 831 citations

Static and dynamic lipid asymmetry in cell membranes

1991 • 796 citations

Large unilamellar liposomes with low uptake into the reticuloendothelial system

1987 • 718 citations

ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes.

1984 • 692 citations

The role of phospholipids and factor Va in the prothrombinase complex.

1980 • 672 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Assembly of the Platelet Prothrombinase Complex Is Linked to Vesiculation of the Platelet Plasma Membrane

1989 • 597 citations

Changes in membrane phospholipid distribution during platelet activation

1983 • 551 citations

Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process.

1993 • 516 citations

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester.

1986 • 487 citations

Fluorescence assay for phospholipid membrane asymmetry

1991 • 484 citations

THE JOURNAL OF BIOLOGICAL CHEMISTRY

1955 • 476 citations

Generation of Prothrombin‐Converting Activity and the Exposure of Phosphatidylserine at the Outer Surface of Platelets

1982 • 472 citations

Lipid Traffic in Animal Cells

1989 • 468 citations

PHOSPHOLIPID TRANSFER PROTEINS

1991 • 445 citations

Phagocytosis as a Surface Phenomenon

1978 • 438 citations

Annexin V as a probe of aminophospholipid exposure and platelet membrane vesiculation: a flow cytometry study showing a role for free sulfhydryl groups

1993 • 348 citations

Spectrin as a stabilizer of the phospholipid asymmetry in the human erythrocyte membrane

1978 • 346 citations

Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size

1991 • 337 citations

Transbilayer movement of phospholipids in red cell and platelet membranes

1991 • 317 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects

1993 • 298 citations

Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane.

1985 • 297 citations

Exposure of phosphatidylserine in the outer leaflet of human red blood cells. Relationship to cell density, cell age, and clearance by mononuclear cells.

1994 • 291 citations

Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase

1990 • 290 citations

cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression

1990 • 275 citations

Assembly of Phospholipids into Cellular Membranes: Biosynthesis, Transmembrane Movement and Intracellular Translocation

1988 • 267 citations

Incorporation and translocation of aminophospholipids in human erythrocytes

1985 • 264 citations

Merocyanine 540, a fluorescent probe sensitive to lipid packing

1983 • 241 citations

Recognition of liposomes by cells: In vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density

1992 • 239 citations

Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter

1985 • 238 citations

Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells. Evidence for a protein-mediated and ATP-dependent process(es).

1987 • 238 citations

Shape changes of giant liposomes induced by an asymmetric transmembrane distribution of phospholipids

1992 • 238 citations

Heterogeneous distribution of filipin--cholesterol complexes across the cisternae of the Golgi apparatus.

1981 • 225 citations

Outside-inside translocation of aminophospholipids in the human erythrocyte membrane is mediated by a specific enzyme

1986 • 224 citations

Asymmetric exchange of vesicle phospholipids catalyzed by the phosphatidylcholine exchange protein. Measurement of inside-outside transitions

1975 • 222 citations

Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.

1989 • 221 citations

The dynamic nature of the Golgi complex.

1989 • 210 citations

Lipid composition of the golgi apparatus of rat kidney and liver in comparison with other subcellular organelles

1975 • 209 citations

Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages.

1986 • 204 citations

Protein Involvement in Transmembrane Lipid Asymmetry

1992 • 200 citations

Quantitative analysis of liposome-cell interactions in vitro: Rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes

1993 • 199 citations

Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes

1987 • 197 citations

Calcium induces transbilayer redistribution of all major phospholipids in human erythrocytes

1992 • 195 citations

Asymmetry and transposition rate of phosphatidylcholine in rat erythrocyte ghosts

1976 • 186 citations

Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation.

1989 • 186 citations

Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein

1989 • 181 citations

The rate of transmembrane movement of cholesterol in the human erythrocyte.

1981 • 179 citations

Heterogeneity in the fluidity of intact erythrocyte membrane and its homogenization upon hemolysis

1976 • 179 citations

Use of phospholipid exchange protein to measure inside-outside transposition in phosphatidylcholine liposomes

1975 • 172 citations

Aminophospholipid translocase of human erythrocytes: phospholipid substrate specificity and effect of cholesterol

1989 • 172 citations

Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide.

1982 • 168 citations

Extensive exchange of rat liver microsomal phospholipids

1977 • 163 citations

Involvement of spectrin in the maintenance of phase-state asymmetry in the erythrocyte membrane

1982 • 159 citations

Phospholipid binding of annexin V: Effects of calcium and membrane phosphatidylserine content

1992 • 154 citations

The structure of bone marrow. Functional interrelationships of vascular and hematopoietic compartments in experimental hemolytic anemia: An electron microscopic study

1965 • 153 citations

Tension in secretory granule membranes causes extensive membrane transfer through the exocytotic fusion pore.

1990 • 148 citations

Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence

1984 • 143 citations

Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.

1993 • 143 citations

Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome

1992 • 142 citations

Analysis of membrane halves: cholesterol.

1976 • 141 citations

Identification of a Cell Surface Protein Complex Mediating Phorbol Ester‐Induced Adhesion (Binding) among Human Mononuclear Leukocytes

1985 • 139 citations

Protein-mediated phospholipid translocation in the endoplasmic reticulum with a low lipid specificity

1990 • 136 citations

Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver.

1987 • 135 citations

Transmembrane distribution of sterol in the human erythrocyte

1991 • 135 citations

Binding of merocyanine 540 to normal and leukemic erythroid cells

1980 • 130 citations

Transbilayer movement of phosphatidylserine in erythrocytes: inhibition of transport and preferential labeling of a 31 000-dalton protein by sulfhydryl reactive reagents

1988 • 129 citations

Phospholipid asymmetry in human erythrocyte ghosts

1985 • 126 citations

Erythrocyte morphology reflects the transbilayer distribution of incorporated phospholipids.

1989 • 125 citations

Calcium-dependent annexin V binding to phospholipids: Stoichiometry, specificity, and the role of negative charge

1993 • 125 citations

Spectrin-phospholipid interaction

1980 • 124 citations

Membrane bilayer balance and erythrocyte shape: a quantitative assessment

1985 • 124 citations

Transport and sorting of membrane lipids

1993 • 123 citations

Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts.

1990 • 123 citations

Organelle biogenesis and intracellular lipid transport in eukaryotes

1991 • 121 citations

Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance

1989 • 119 citations

Partial purification and characterization of the human erythrocyte Mg²⁺ ‐ATPase A candidate aminophospholipid translocase

1990 • 114 citations

Phosphorylcholine acts as a Ca2+-dependent receptor molecule for lymphocyte perforin

1989 • 114 citations

Fusion of coated vesicles with lysosomes: Measurement with a fluorescence assay

1983 • 113 citations

Asymmetric Transbilayer Distribution of Sterol across Plasma Membranes Determined by Fluorescence Quenching of Dehydroergosterol

1982 • 110 citations

Calcium-induced transbilayer scrambling of fluorescent phospholipid analogs in platelets and erythrocytes

1994 • 110 citations

Transbilayer exchange of phosphatidylethanolamine for phosphatidylcholine and N-acetimidoylphosphatidylethanolamine in single-walled bilayer vesicles

1975 • 109 citations

Transmembrane diffusion of fluorescent phospholipids in human erythrocytes

1991 • 108 citations

Measurement of outward translocation of phospholipids across human erythrocyte membrane.

1988 • 107 citations

Determination of lipid asymmetry in human red cells by resonance energy transfer

1987 • 106 citations

Formation of aqueous pores in the human erythrocyte membrane after oxidative cross-linking of spectrin by diamide

1983 • 105 citations

Possible relationship between membrane proteins and phospholipid asymmetry in the human erythrocyte membrane

1976 • 105 citations

Transbilayer movement of cholesterol in the human erythrocyte membrane.

1988 • 103 citations

The interaction of spectrin-actin and synthetic phospholipids. II. The interaction with phosphatidylserine

1979 • 102 citations

Studies on sickled erythrocytes provide evidence that the asymmetric distribution of phosphatidylserine in the red cell membrane is maintained by both ATP-dependent translocation and interaction with membrane skeletal proteins

1988 • 101 citations

AN ELECTRON MICROSCOPIC STUDY OF NUCLEAR ELIMINATION FROM THE LATE ERYTHROBLAST

1967 • 100 citations

Electrostatic coupling of spectrin dimers to phosphatidylserine-containing lipid lamellae

1987 • 96 citations

Reconstitution of a phospholipid flippase from rat liver microsomes

1987 • 96 citations

Identification of the protein 4.1 binding site to phosphatidylserine vesicles

1988 • 94 citations

Alterations in Organization of Phospholipids in Erythrocytes as Factor in Adherence to Endothelial Cells in Diabetes Mellitus

1988 • 92 citations

Structural conservation and functional diversity of V-ATPases

1992 • 91 citations

Purification and properties of a vanadate- and N-ethylmaleimide-sensitive ATPase from chromaffin granule membranes.

1988 • 88 citations

Asymmetric distribution of phospholipids in spectrin-poor erythrocyte vesicles

1988 • 88 citations

Phospholipid outside-inside translocation in lymphocyte plasma membranes is a protein-mediated phenomenon

1987 • 87 citations

Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane

1991 • 86 citations

The rapid transmembrane movement of cholesterol in small unilamellar vesicles

1979 • 86 citations

Transmembrane movements of lipids

1990 • 86 citations

Intracellular phospholipid movement and the role of phospholipid transfer proteins in animal cells

1983 • 86 citations

Flip-flop rates of individual molecular species of phosphatidylcholine in the human red cell membrane

1986 • 85 citations

Maintenance of lipid asymmetry in red blood cells and ghosts: effect of divalent cations and serum albumin on the transbilayer distribution of phosphatidylserine

1990 • 85 citations

Membrane phospholipid asymmetry as a factor in erythrocyte‐endothelial cell interactions

1985 • 83 citations

Asymmetric lateral mobility of phospholipids in the human erythrocyte membrane.

1986 • 81 citations

ATP-dependent aminophospholipid translocation in erythrocyte vesicles: Stoichiometry of transport

1993 • 81 citations

Alteration of the aminophospholipid translocase activity during in vivo and artificial aging of human erythrocytes

1990 • 80 citations

Altered lipid packing identifies apoptotic thymocytes

1993 • 77 citations

Requirement for phosphatidylinositol 4,5-bisphosphate in the Ca(2+)-induced phospholipid redistribution in the human erythrocyte membrane.

1994 • 75 citations

Aminophospholipid translocation in erythrocytes: evidence for the involvement of a specific transporter and an endofacial protein

1990 • 74 citations

Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase.

1981 • 72 citations

Hyperglycemia induces a loss of phospholipid asymmetry in human erythrocytes

1993 • 72 citations

Transbilayer distribution and mobility of phosphatidylinositol in human red blood cells.

1990 • 70 citations

Radioiodinated, photoactivatable phosphatidylcholine and phosphatidylserine: transfer properties and differential photoreactive interaction with human erythrocyte membrane proteins

1987 • 68 citations

Involvement of Rh blood group polypeptides in the maintenance of aminophospholipid asymmetry

1990 • 67 citations

Translocation of spin-labeled phospholipids through plasma membrane during thrombin- and ionophore A23187-induced platelet activation

1993 • 66 citations

Membrane phospholipid organization in calcium-loaded human erythrocytes

1987 • 64 citations

Lipid transmembrane asymmetry and flip-flop in biological membranes and in lipid bilayers

1993 • 63 citations

Red cell membrane abnormalities in chronic myeloid leukaemia

1983 • 62 citations

Absence of transbilayer diffusion of spin-labeled sphingomyelin on human erythrocytes. Comparison with the diffusion of several spin-labeled glycerophospholipids

1985 • 61 citations

The red cell membrane contains three different adenosine triphophatases.

1975 • 60 citations

The sphingomyelin pools in the outer and inner layer of the human erythrocyte membrane are composed of different molecular species

1983 • 60 citations

Transbilayer mobility and distribution of red cell phospholipids during storage.

1993 • 60 citations

The present status of erythrocyte spectrin structure: The 106‐residue repetitive structure is a basic feature of an entire class of proteins

1986 • 58 citations

Merocyanine 540 as a Flow Cytometric Probe of Membrane Lipid Organization in Leukocytes

1988 • 58 citations

Maintenance of membrane phospholipid asymmetry Lipid‐cytoskeletal interactions or lipid pump?

1987 • 55 citations

Alteration of red cell membrane organization in sickle cell anaemia

1986 • 53 citations

Membrane skeleton-bilayer interaction is not the major determinant of membrane phospholipid asymmetry in human erythrocytes

1990 • 53 citations

Transmembrane movement of cholesterol in human erythrocytes.

1977 • 53 citations

Rapid loss and restoration of lipid asymmetry by different pathways in resealed erythrocyte ghosts

1992 • 52 citations

Effects of divalent cations on lipid flip-flop in the human erythrocyte membrane

1990 • 52 citations

Effect of erythrocyte transbilayer phospholipid distribution on fusion with vesicular stomatitis virus

1990 • 51 citations

Organelle biogenesis and intracellular lipid transport in eukaryotes.

1991 • 51 citations

Cholesterol distribution between the two halves of the lipid bilayer of human erythrocyte ghost membranes.

1978 • 51 citations

Interaction of erythrocyte protein 4.1 with phospholipids. A monolayer and liposome study

1988 • 50 citations

Phospholipid asymmetry in renal brush-border membranes

1988 • 50 citations

Phospholipid transmembrane domains and lateral diffusion in fibroblasts.

1993 • 49 citations

Purification of a Vanadate-sensitive ATPase from Clathrin-coated Vesicles of Bovine Brain

1989 • 46 citations

Weak interaction of spectrin with phosphatidylcholine‐phosphatidylserine multilayers: A ²H and ³¹P NMR study

1989 • 46 citations

Membrane alterations in cellular aging: Susceptibility of phospholipids in density (age)-separated human erythrocytes to phospholipase A2

1982 • 45 citations

Fluorescence quenching of spectrin and other red cell membrane cytoskeletal proteins. Relation to hydrophobic binding sites

1992 • 45 citations

Distribution of shape-changing compounds across the red cell membrane

1980 • 44 citations

Assembly of the endoplasmic reticulum phospholipid bilayer. Transporters for phosphatidylcholine and metabolites.

1987 • 44 citations

Fatty acids in phospholipids isolated from human red cells

1966 • 42 citations

Prothrombin activation on membranes with anionic lipids containing phosphate, sulfate and/or carboxyl groups

1990 • 42 citations

Increased aminophospholipid translocase activity in human platelets during secretion

1990 • 41 citations

Binding of perforin to membranes is sensitive to lipid spacing and not headgroup

1992 • 40 citations

Phosphatidylserine vesicles inhibit phagocytosis of erythrocytes with a symmetric transbilayer distribution of phospholipids

1994 • 40 citations

Phospholipids of subcellular organelles isolated from cultured BHK cells

1977 • 39 citations

Regulation of a candidate aminophospholipid-transporting ATPase by lipid

1993 • 39 citations

Alterations in plasma membrane lipid organization during lymphocyte differentiation

1986 • 38 citations

Characterization of the P‐Type and V‐Type ATPases of Cholinergic Synaptic Vesicles and Coupling of Nucleotide Hydrolysis to Acetylcholine Transport

1992 • 38 citations

Surface exposure of phosphatidylserine is associated with the swelling and osmotically-induced fusion of human erythrocytes in the presence of Ca2+

1990 • 38 citations

Transmembrane redistribution of phospholipids of the human red cell membrane during hypotonic hemolysis

1992 • 38 citations

Involvement of ATP-dependent aminophospholipid translocation in maintaining phospholipid asymmetry in diamide-treated human erythrocytes

1989 • 36 citations

Membrane phospholipid organization as a determinant of blood cell‐reticuloendothelial cell interactions

1987 • 36 citations

The distribution of erythrocyte phospholipids in hereditary spherocytosis demonstrates a minimal role for erythrocyte spectrin on phospholipid diffusion and asymmetry

1993 • 36 citations

Phospholipid Transverse Diffusion in Synaptosomes: Evidence for the Involvement of the Aminophospholipid Translocase

1990 • 35 citations

Accessibility of phospholipids in the chromaffin granule membrane

1978 • 35 citations

Asymmetric synthesis followed by transmembrane movement of phosphatidylethanolamine in rat liver endoplasmic reticulum

1982 • 33 citations

Plasma Membrane Phospholipid Asymmetry and Its Maintenance: The Human Erythrocyte as a Model

1994 • 33 citations

The use of fluorescamine as a permeant probe to localize phosphatidylethanolamine in intact friend erythroleukaemic cells

1984 • 33 citations

Quantitative comparison between aminophospholipid translocase activity in human erythrocytes and in K562 cells

1993 • 32 citations

Functional heterogeneity of polyphosphoinositides in human erythrocytes

1989 • 32 citations

Membrane recapture and early triggered secretion from the newly formed endocytotic compartment in bovine chromaffin cells.

1992 • 32 citations

Enucleation eliminates a differentiation-specific surface marker from normal and leukemic murine erythroid cells

1982 • 31 citations

Relation between the organization of spectrin and of membrane lipids in lymphocytes.

1988 • 31 citations

Temperature and ionic effects on the interaction of erythroid spectrin with phosphatidylserine membranes

1993 • 31 citations

Effect of transbilayer phospholipid distribution on erythrocyte fusion

1989 • 28 citations

The role of phospholipid asymmetry in calcium-phosphate-induced fusion of human erythrocytes.

1992 • 27 citations

A model for the extracellular release of PAF: The influence of plasma membrane phospholipid asymmetry

1991 • 27 citations

Isolation of plasma membranes from cultured glioma cells and application to evaluation of membrane sphingomyelin turnover

1988 • 25 citations

Merocyanine 540 recognizes membrane abnormalities of erythrocytes in chronic myelogenous leukemia

1985 • 21 citations

The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump

1984 • 21 citations

Disruption of phospholipid asymmetry in erythrocyte vesicles deficient in spectrin

1985 • 20 citations

Bilayer/cytoskeleton interactions in lipid-symmetric erythrocytes assessed by a photoactivable phospholipid analog

1991 • 18 citations

Plasma membrane lipid organization and the adherence of differentiating lymphocytes to macrophages

1989 • 17 citations

Alterations of phospholipid asymmetry in the membrane of spontaneously aggregated platelets in diabetes

1988 • 16 citations

Phosphatidylserine headgroup diastereomers translocate equivalently across human erythrocyte membranes

1994 • 15 citations

Purification and Subunit Composition of a Cholinergic Synaptic Vesicle Glycoprotein, Phosphointermediate‐Forming ATPase

1989 • 14 citations

Asymmetry in trans-bilayer lateral pressure may drive expansion of the secretion fusion pore

1993 • 12 citations

Protein-Mediated Phospholipid Movement in Red Blood Cells

1994 • 12 citations

Characterization of the Mg(2+)-ATPase activity of the human erythrocyte membrane.

1993 • 11 citations

Role of Phospholipid Asymmetry in Cellular Membrane Fusion

1988 • 11 citations

Phospholipid asymmetry during erythrocyte deformation: maintenance of the unit membrane

1992 • 9 citations

Lipid sorting—measurement and interpretation

1993 • 9 citations

Abnormal erythrocyte membrane phospholipid organisation in chronic myeloid leukaemia

1987 • 8 citations

A fluorescent dye which recognizes mature peripheral erythrocytes of myeloproliferative disorders

1987 • 7 citations

Plasma membrane lipid packing and leukocyte function‐associated antigen‐1‐dependent aggregation of lymphocytes

1993 • 7 citations

Functional and pathological significance of phospholipid asymmetry in erythrocyte membranes

1990 • 5 citations

Deleted Work

1955 • 0 citations