Tracking down lipid flippases and their biological functions

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions

1974 • 1,362 citations

Inside-outside transitions of phospholipids in vesicle membranes

1971 • 942 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement

1993 • 831 citations

Membrane Structure: Some General Principles

1973 • 825 citations

Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

2002 • 708 citations

ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes.

1984 • 692 citations

Asymmetrical Lipid Bilayer Structure for Biological Membranes

1972 • 606 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine.

2000 • 529 citations

A Subfamily of P-Type ATPases with Aminophospholipid Transporting Activity

1996 • 472 citations

ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein

2001 • 471 citations

The Clementine Bistatic Radar Experiment

1996 • 470 citations

ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p

1998 • 379 citations

Drs2p-related P-type ATPases Dnf1p and Dnf2p Are Required for Phospholipid Translocation across the Yeast Plasma Membrane and Serve a Role in Endocytosis

2003 • 353 citations

Exposure of platelet membrane phosphatidylserine regulates blood coagulation

2003 • 341 citations

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

2002 • 308 citations

Isolation of an Erythrocyte Membrane Protein that Mediates Ca2+-dependent Transbilayer Movement of Phospholipid

1996 • 301 citations

The biological role of dolichol

1988 • 296 citations

Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane

2001 • 289 citations

Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein

2002 • 280 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Structure, organization, and function of glycosphingolipids in membrane

2003 • 274 citations

Shape change and physical properties of giant phospholipid vesicles prepared in the presence of an AC electric field

1996 • 270 citations

Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface

2002 • 268 citations

Role for Drs2p, a P-Type Atpase and Potential Aminophospholipid Translocase, in Yeast Late Golgi Function

1999 • 261 citations

An Essential Subfamily of Drs2p-related P-Type ATPases Is Required for Protein Trafficking between Golgi Complex and Endosomal/Vacuolar System

2002 • 259 citations

Capacitation Induces Cyclic Adenosine 3′,5′-Monophosphate-Dependent, but Apoptosis-Unrelated, Exposure of Aminophospholipids at the Apical Head Plasma Membrane of Boar Sperm Cells1

2002 • 258 citations

Role of ABCG1 and other ABCG family members in lipid metabolism

2001 • 256 citations

Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter

1985 • 238 citations

Shape changes of giant liposomes induced by an asymmetric transmembrane distribution of phospholipids

1992 • 238 citations

Lipid topogenesis

1981 • 224 citations

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1

2002 • 216 citations

Unraveling the Mysteries of Phospholipid Scrambling

2001 • 211 citations

Specific Docking of Apolipoprotein A-I at the Cell Surface Requires a Functional ABCA1 Transporter

2001 • 209 citations

Functional Cloning of the Miltefosine Transporter

2003 • 208 citations

Familial intrahepatic cholestasis 1: Studies of localization and function

2001 • 193 citations

ATP-binding Cassette Transporter A7 (ABCA7) Binds Apolipoprotein A-I and Mediates Cellular Phospholipid but Not Cholesterol Efflux

2003 • 191 citations

Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins

2003 • 179 citations

Continuous Analysis of the Mechanism of Activated Transbilayer Lipid Movement in Platelets

1995 • 179 citations

Aminophospholipid translocase of human erythrocytes: phospholipid substrate specificity and effect of cholesterol

1989 • 172 citations

Drs2p-Dependent Formation of Exocytic Clathrin-Coated Vesicles In Vivo

2002 • 164 citations

Bidirectional transbilayer movement of phospholipid analogs in human red blood cells. Evidence for an ATP-dependent and protein-mediated process.

1992 • 160 citations

Chilling Tolerance in Arabidopsis Involves ALA1, a Member of a New Family of Putative Aminophospholipid Translocases

2000 • 159 citations

Role of ABC transporters in secretion of cholesterol from liver into bile

2002 • 158 citations

The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane

1999 • 156 citations

A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome

2001 • 152 citations

Enhancement of endocytosis due to aminophospholipid transport across the plasma membrane of living cells

1999 • 146 citations

Protein-mediated phospholipid translocation in the endoplasmic reticulum with a low lipid specificity

1990 • 136 citations

A Novel Membrane Protein, Ros3p, Is Required for Phospholipid Translocation across the Plasma Membrane inSaccharomyces cerevisiae

2002 • 129 citations

Lem3p Is Essential for the Uptake and Potency of Alkylphosphocholine Drugs, Edelfosine and Miltefosine

2003 • 129 citations

Influence of transbilayer area asymmetry on the morphology of large unilamellar vesicles

1995 • 126 citations

Phospholipid Flop Induced by Transmembrane Peptides in Model Membranes Is Modulated by Lipid Composition

2002 • 122 citations

A 2-Mb Sequence-Ready Contig Map and a Novel Immunoglobulin Superfamily Gene IGSF4 in the LOH Region of Chromosome 11q23.2

1999 • 120 citations

The complete inventory of the yeast Saccharomyces cerevisiae P‐type transport ATPases

1997 • 120 citations

Transbilayer Movement of Phospholipids at the Main Phase Transition of Lipid Membranes: Implications for Rapid Flip-Flop in Biological Membranes

2002 • 118 citations

Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833

1998 • 117 citations

Endocytosis Switch Controlled by Transmembrane Osmotic Pressure and Phospholipid Number Asymmetry

2000 • 115 citations

Reconstitution of Phospholipid Scramblase Activity from Human Blood Platelets

1996 • 110 citations

Calcium-induced transbilayer scrambling of fluorescent phospholipid analogs in platelets and erythrocytes

1994 • 110 citations

Lipid Traffic: The ABC of Transbilayer Movement

2000 • 109 citations

Ultrafast Glycerophospholipid-selective Transbilayer Motion Mediated by a Protein in the Endoplasmic Reticulum Membrane

1996 • 108 citations

Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis.

1996 • 106 citations

Plasma Membrane Translocation of Fluorescent-labeled Phosphatidylethanolamine Is Controlled by Transcription Regulators, PDR1 and PDR3

1997 • 106 citations

Lactosylceramide is synthesized in the lumen of the Golgi apparatus

1994 • 103 citations

The Human Aminophospholipid-Transporting ATPase Gene ATP10C Maps Adjacent to UBE3A and Exhibits Similar Imprinted Expression

2001 • 102 citations

Specific proteins are required to translocate phosphatidylcholine bidirectionally across the endoplasmic reticulum

2000 • 100 citations

New perspectives on the regulation of intermembrane glycerophospholipid traffic

2003 • 98 citations

Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane

1998 • 96 citations

Requirement for Neo1p in Retrograde Transport from the Golgi Complex to the Endoplasmic Reticulum

2003 • 94 citations

Loss of Drs2p Does Not Abolish Transfer of Fluorescence-labeled Phospholipids across the Plasma Membrane of Saccharomyces cerevisiae

1998 • 91 citations

Rapid Flip-Flop of Phospholipids in Endoplasmic Reticulum Membranes Studied by a Stopped-Flow Approach

2000 • 90 citations

Investigation on lipid asymmetry using lipid probes

2002 • 87 citations

Effect of the phase transition on the transbilayer movement of dimyristoyl phosphatidylcholine in unilamellar vesicles

1978 • 86 citations

Transport of phosphatidylserine via MDR1 (multidrug resistance 1)P-glycoprotein in a human gastric carcinoma cell line

2002 • 86 citations

Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor

2001 • 82 citations

Differential expression of putative transbilayer amphipath transporters

1999 • 82 citations

Membrane-Spanning Peptides Induce Phospholipid Flop: A Model for Phospholipid Translocation across the Inner Membrane of E. coli

2001 • 80 citations

Transbilayer Movement of Monohexosylsphingolipids in Endoplasmic Reticulum and Golgi Membranes

2002 • 79 citations

NBD‐Labeled Phosphatidylcholine and Phosphatidylethanolamine are Internalized by Transbilayer Transport across the Yeast Plasma Membrane

2001 • 70 citations

Endocytosis Is Enhanced in Tangier Fibroblasts

2001 • 63 citations

Multiple Members of a Third Subfamily of P-Type ATPases Identified by Genomic Sequences and ESTs

1998 • 63 citations

Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor

2001 • 55 citations

Rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis‐deficient yeast cells does not require the Drs2 protein

1999 • 55 citations

Genetic Defects in Hepatocanalicular Transport

2000 • 50 citations

Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes

2000 • 46 citations

Protein-Mediated Inward Translocation of Phospholipids Occurs in both the Apical and Basolateral Plasma Membrane Domains of Epithelial Cells

1998 • 37 citations

Transverse Redistribution of Phospholipids during Human Platelet Activation: Evidence for a Vectorial Outflux Specific to Aminophospholipids

1995 • 32 citations

Rapid transport of phospholipids across the plasma membrane of Leishmania infantum

2003 • 25 citations

Topological studies on the enzymes catalyzing the biosynthesis of Glc-P-dolichol and the triglucosyl cap of Glc3Man9GlcNAc2-P-P-dolichol in microsomal vesicles from pig brain: use of the processing glucosidases I/II as latency markers

1998 • 20 citations

Aminophospholipids Have No Access to the Luminal Side of the Biliary Canaliculus

2003 • 18 citations

Lipid‐Based Membrane Domains: Physics Meets Immunology

2003 • 6 citations