Cyclin D3 Sensitizes Tumor Cells to Tumor Necrosis Factor-Induced, c-Myc-Dependent Apoptosis

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Transforming growth factor beta and cell cycle regulation.

1995 • 368 citations

The role of c-myc in cell growth

1993 • 365 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Apoptosis and the cell cycle

1995 • 334 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

1995 • 294 citations

Inhibition of apoptosis by the retinoblastoma gene product.

1995 • 286 citations

Transforming growth factor beta effects on expression of G1 cyclins and cyclin-dependent protein kinases.

1993 • 276 citations

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor

1993 • 253 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

1994 • 238 citations

Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

1994 • 227 citations

Participation of cyclin A in Myc-induced apoptosis.

1994 • 207 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2.

1991 • 189 citations

Yin-yang 1 activates the c-myc promoter.

1993 • 187 citations

An E-Box-Mediated Increase in cad Transcription at the G₁/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

1995 • 169 citations

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.

1995 • 164 citations

Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage.

1995 • 156 citations

c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha.

1994 • 141 citations

Expression of the positive regulator of cell cycle progression, cyclin D3, is induced during differentiation of myoblasts into quiescent myotubes.

1995 • 141 citations

p53-mediated apoptosis in HeLa cells can be overcome by excess pRB.

1995 • 136 citations

Positive and Negative Regulation of D-type Cyclin Expression in Skeletal Myoblasts by Basic Fibroblast Growth Factor and Transforming Growth Factor β

1995 • 133 citations

Activation-Induced T-Cell Death Is Cell Cycle Dependent and Regulated by Cyclin B

1995 • 126 citations

Sequence-Specific Transcriptional Activation by Myc and Repression by Max

1993 • 124 citations

Apoptosis and signal transduction: clues to a molecular mechanism

1993 • 119 citations

Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.

1994 • 115 citations

Nuclear c-Myc Plays an Important Role in the Cytotoxicity of Tumor Necrosis Factor Alpha in Tumor Cells

1994 • 89 citations

Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes.

1992 • 81 citations

Evidence for two mechanisms by which tumor necrosis factor kills cells

1989 • 80 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas.

1994 • 52 citations