Channel-induced apoptosis of infected host cells?the case of malaria

Mitochondria and Apoptosis

1998 • 8,909 citations

Down-Regulation of Na⁺/K⁺ATPase Activity by Human Parvovirus B19 Capsid Protein VP1

2013 • 8,607 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

Transport of lactate and other monocarboxylates across mammalian plasma membranes

1993 • 736 citations

Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis

2000 • 707 citations

A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis

1997 • 551 citations

Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia

1998 • 395 citations

Membrane Transport in the Malaria-Infected Erythrocyte

2001 • 393 citations

Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria

2001 • 391 citations

Role of Ca²⁺-activated K⁺channels in human erythrocyte apoptosis

2003 • 384 citations

Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis

2001 • 362 citations

Cation channels trigger apoptotic death of erythrocytes

2003 • 337 citations

The phosphatidylserine receptor: a crucial molecular switch?

2001 • 325 citations

Phosphatidylserine‐related adhesion of human erythrocytes to vascular endothelium

1999 • 304 citations

Caspase Independent/Dependent Regulation of K+, Cell Shrinkage, and Mitochondrial Membrane Potential during Lymphocyte Apoptosis

1999 • 297 citations

A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasite

2000 • 262 citations

Excess hemoglobin digestion and the osmotic stability ofPlasmodium falciparum–infected red blood cells

2003 • 259 citations

CD95/CD95 Ligand Interactions on Epithelial Cells in Host Defense to Pseudomonas aeruginosa

2000 • 251 citations

Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel.

1994 • 250 citations

Oxidation induces a Cl⁻‐dependent cation conductance in human red blood cells

2002 • 228 citations

Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes

2003 • 226 citations

Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation

1996 • 225 citations

Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum

1993 • 221 citations

Cytoadherence and sequestration in Plasmodium falciparum: defining the ties that bind

2003 • 217 citations

Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes

1998 • 200 citations

Enhanced Erythrocyte Apoptosis in Sickle Cell Anemia, Thalassemia and Glucose-6-Phosphate Dehydrogenase Deficiency

2002 • 197 citations

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

1997 • 188 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

Cation transport and volume regulation in sickle red blood cells

1993 • 184 citations

Dependence of <i>Plasmodium falciparum In Vitro</i> Growth on the Cation Permeability of the Human Host Erythrocyte

2003 • 182 citations

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

1999 • 176 citations

Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts

2001 • 176 citations

Cytoadherence of Malaria-Infected Red Blood Cells Involves Exposure of Phosphatidylserine

2002 • 169 citations

Plasmodium falciparum activates endogenous Cl- channels of human erythrocytes by membrane oxidation

2002 • 165 citations

The role of apoptotic volume decrease and ionic homeostasis in the activation and repression of apoptosis

2004 • 150 citations

The 2P-domain K + channels: role in apoptosis and tumorigenesis

2004 • 149 citations

Physiology of apoptosis

2000 • 144 citations

The Malaria Parasite Supplies Glutathione to its Host Cell — Investigation of Glutathione Transport and Metabolism in Human Erythrocytes Infected with Plasmodium Falciparum

1997 • 144 citations

Activation of calcium-dependent potassium channels in deoxygenated sickled red cells.

1987 • 143 citations

Calcium signaling in a low calcium environment

2003 • 140 citations

The hSK4 (KCNN4) isoform is the Ca ^{2 +} -activated K ⁺ channel (Gardos channel) in human red blood cells

2003 • 133 citations

Perturbation of the pump-leak balance for Na⁺ and K⁺ in malaria-infected erythrocytes

2001 • 132 citations

Electrophysiological Properties of the <i>Plasmodium falciparum</i>-Induced Cation Conductance of Human Erythrocytes

2003 • 129 citations

Dual roles of plasmalemmal chloride channels in induction of cell death

2004 • 115 citations

The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation

2000 • 109 citations

Hexose-monophosphate shunt activity in intact Plasmodium falciparum-infected erythrocytes and in free parasites

1994 • 103 citations

A stretch‐activated anion channel is up‐regulated by the malaria parasite plasmodium falciparum

2002 • 102 citations

FUNCTIONAL PROPERTIES AND PHYSIOLOGICAL ROLES OF ORGANIC SOLUTE CHANNELS

1998 • 99 citations

The redox status of malaria-infected erythrocytes: an overview with an emphasis on unresolved problems

1994 • 96 citations

Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons

2004 • 92 citations

Effects of Ca++ Depletion on the Asexual Cell Cycle of Plasmodium Falciparum

1982 • 91 citations

Evidence for a voltage-gated, non-selective cation channel in the human red cell membrane

1991 • 86 citations

Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins.

1993 • 85 citations

Mechanism of the increase in cation permeability of human erythrocytes in low-chloride media. Involvement of the anion transport protein capnophorin.

1985 • 83 citations

Cellular taurine release triggered by stimulation of the Fas(CD95) receptor in Jurkat lymphocytes

1998 • 80 citations

Sphingolipid synthesis as a target for chemotherapy against malaria parasites.

1995 • 75 citations

Inhibition of erythrocyte cation channels and apoptosis by ethylisopropylamiloride

2003 • 75 citations

Blunted Apoptosis of Erythrocytes from Taurine Transporter Deficient Mice

2003 • 73 citations

Increased permeability of the malaria-infected erythrocyte to organic cations

2000 • 71 citations

Non-selective voltage-activated cation channel in the human red blood cell membrane

1999 • 70 citations

The accumulation and metabolism of a fluorescent ceramide derivative inPlasmodium falciparum-infected erythrocytes

1991 • 70 citations

On the mode of action of phlorizin as an antimalarial agent in in vitro cultures of plasmodium falciparum

1987 • 70 citations

Ion channels and membrane rafts in apoptosis

2004 • 69 citations

Effects of low ionic strength media on passive human red cell monovalent cation transport.

1991 • 69 citations

Alterations in erythrocyte membrane phospholipid organization due to the intracellular growth of the human malaria parasite,Plasmodium falciparum

1991 • 68 citations

Novel Anion Dependence of Induced Cation Transport in Malaria-infected Erythrocytes

1995 • 65 citations

The voltage-gated non-selective cation channel from human red cells is sensitive to acetylcholine

1993 • 63 citations

Biosynthesis of glycosphingolipids de-novo by the human malaria parasite Plasmodium falciparum

2001 • 63 citations

Release of taurine in apoptotic cerebellar granule neurons in culture

1999 • 62 citations

Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum

2000 • 59 citations

Innate resistance in malaria

1976 • 58 citations

Modulation of Whole‐Cell Currents in Plasmodium Falciparum‐Infected Human Red Blood Cells by Holding Potential and Serum

2003 • 57 citations

Transport pathways in the malaria-infected erythrocyte their characterization and their use as potential targets for chemotherapy

1994 • 56 citations

The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes

2000 • 55 citations

Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria‐infected erythrocytes

1993 • 52 citations

Redox processes in malaria and other parasitic diseases

1994 • 51 citations

A Novel Pathway for Ca++ Entry into Plasmodium falciparum-Infected Blood Cells

1996 • 48 citations

Ceramide mediates growth inhibition of the Plasmodium falciparum parasite

2003 • 46 citations

Functional state of the plasma membrane Ca²⁺ pump in Plasmodium falciparum‐infected human red blood cells

2000 • 43 citations

An intracellular simian malarial parasite (Plasmodium knowlesi) induces stage-dependent alterations in membrane phospholipid organization of its host erythrocyte

1987 • 42 citations

Phospholipid asymmetry in the plasma membrane of malaria infected erythrocytes

1990 • 37 citations

Passive Ca 2+ Transport and Ca 2+ -Dependent K + Transport in Plasmodium falciparum -Infected Red Cells

1999 • 37 citations

Malaria parasite Plasmodium gallinaceum up‐regulates host red blood cell channels

2001 • 33 citations

Covalent modification of the permeability pathways induced in the human erythrocyte membrane by the malarial parasitePlasmodium falciparum

1987 • 27 citations

Osmotic effects of protein polymerization: Analysis of volume changes in sickle cell anemia red cells following deoxy-hemoglobin S polymerization

1991 • 23 citations

Activation of a novel organic solute transporter in mammalian red blood cells.

1995 • 23 citations

The role of calcium ions in the invasion of Plasmodium falciparum.

1990 • 22 citations

Inhibition of interferon-γ expression by osmotic shrinkage of peripheral blood lymphocytes

2003 • 20 citations

Regulation of Kv1.3 during Fas-Induced Apoptosis

1997 • 13 citations

Pathogens, Host-Cell Invasion and Disease

2001 • 6 citations

Deleted Work

1955 • 0 citations