Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

1990 • 654 citations

CD95 Signaling via Ceramide-rich Membrane Rafts

2001 • 630 citations

Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

2001 • 521 citations

Acid sphingomyelinase deficient mice: a model of types A and B Niemann–Pick disease

1995 • 469 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia

1998 • 395 citations

Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria

2001 • 391 citations

Ceramide Channels Increase the Permeability of the Mitochondrial Outer Membrane to Small Proteins

2002 • 367 citations

Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis

2001 • 362 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Cation channels trigger apoptotic death of erythrocytes

2003 • 337 citations

Ceramide Induces Cytochrome c Release from Isolated Mitochondria

1999 • 273 citations

Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3

2001 • 248 citations

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

2002 • 243 citations

Oxidation induces a Cl⁻‐dependent cation conductance in human red blood cells

2002 • 228 citations

Enhanced Erythrocyte Apoptosis in Sickle Cell Anemia, Thalassemia and Glucose-6-Phosphate Dehydrogenase Deficiency

2002 • 197 citations

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

1997 • 188 citations

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

2002 • 187 citations

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids

1999 • 176 citations

Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts

2001 • 176 citations

Cytoadherence of Malaria-Infected Red Blood Cells Involves Exposure of Phosphatidylserine

2002 • 169 citations

Plasmodium falciparum activates endogenous Cl- channels of human erythrocytes by membrane oxidation

2002 • 165 citations

Ca2+sensitivity of phospholipid scrambling in human red cell ghosts

1999 • 163 citations

Induction of Ceramide-mediated Apoptosis by the Anticancer Phospholipid Analog, Hexadecylphosphocholine

1998 • 162 citations

Physiology of apoptosis

2000 • 144 citations

Role of Acidic Sphingomyelinase in Fas/CD95-mediated Cell Death

2000 • 141 citations

Ceramide signalling: regulatory role in cell proliferation, differentiation and apoptosis in human epidermis

1997 • 115 citations

Protection of Renal Inner Medullary Epithelial Cells from Apoptosis by Hypertonic Stress-induced p53 Activation

2000 • 113 citations

Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells

2002 • 108 citations

Resistance to CD95/Fas‐induced and ceramide‐mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release

2000 • 98 citations

Ceramide and sphingomyelinases in the regulation of stress responses

1999 • 91 citations

Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells

2001 • 86 citations

Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis

2002 • 79 citations

Inhibition and Stimulation of Phospholipid Scrambling Activity. Consequences for Lipid Asymmetry, Echinocytosis, and Microvesiculation of Erythrocytes

2001 • 76 citations

Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy

2001 • 75 citations

Phospholipid metabolism of serine in Plasmodium-infected erythrocytes involves phosphatidylserine and direct serine decarboxylation

1997 • 73 citations

The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin—Darby canine kidney cells

1991 • 71 citations

Stimulation of TNFα expression by hyperosmotic stress

2002 • 67 citations

Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin

1997 • 66 citations

Cell volume regulation in immune cell apoptosis

2000 • 66 citations

Ceramide induces cytochrome c release from isolated mitochondria

1999 • 63 citations

Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum

2000 • 59 citations

Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells

2002 • 59 citations

Invited Review: Cell Volume Control and Signal Transduction in Apoptosis

2002 • 49 citations

Cytoplasmic calcium buffers in intact human red cells.

1997 • 44 citations

Functional state of the plasma membrane Ca²⁺ pump in Plasmodium falciparum‐infected human red blood cells

2000 • 43 citations

Hyperosmotic stress‐induced apoptosis and tau phosphorylation in human neuroblastoma cells

2001 • 42 citations

The Pathophysiology of Ischaemic Acute Renal Failure

1986 • 41 citations

The human papillomavirus type 16 (HPV-16) E5 protein sensitizes human keratinocytes to apoptosis induced by osmotic stress

2002 • 32 citations

Two new sphingomyelin analogues inhibit phosphatidylcholine biosynthesis by decreasing membrane-bound CTP: phosphocholine cytidylyltransferase levels in HaCaT cells

1995 • 27 citations

Activation of heat shock factor 1 by hyperosmotic or hypo-osmotic stress is drastically attenuated in normal human fibroblasts during senescence

2000 • 26 citations