Behavioral Indices in Antipsychotic Drug Discovery

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

The current status of the dopamine hypothesis of schizophrenia

1988 • 962 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia

2003 • 435 citations

BEHAVIORAL EFFECTS OF SOME PSYCHOPHARMACOLOGICAL AGENTS

1957 • 415 citations

Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia

2003 • 318 citations

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

2008 • 312 citations

Acute and chronic effects of ketamine upon human memory: a review

2006 • 283 citations

SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia

2006 • 241 citations

Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat

2007 • 239 citations

Animal behavior models of the mechanisms underlying antipsychotic atypicality

2003 • 230 citations

Neurochemical, Electrophysiological and Pharmacological Profiles of the Selective Inhibitor of the Glycine Transporter-1 SSR504734, a Potential New Type of Antipsychotic

2005 • 216 citations

The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?

1999 • 186 citations

Phencyclidine in the Social Interaction Test: An Animal Model of Schizophrenia with Face and Predictive Validity

1999 • 161 citations

WAY-163909 [(7bR,10aR)-1,2,3,4,8,9,10,10a-Octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole]: A Novel 5-Hydroxytryptamine 2C Receptor-Selective Agonist with Preclinical Antipsychotic-Like Activity

2006 • 142 citations

Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Test of predictive validity

2004 • 137 citations

Striatal dopamine receptors become supersensitive while rats are given trifluoperazine for six months

1979 • 125 citations

Comparison of dopamine receptor antagonists on hyperlocomotion induced by cocaine, amphetamine, MK-801 and the dopamine D 1 agonist C-APB in mice

1999 • 122 citations

Effects of the 5-HT7 receptor antagonist SB-258741 in animal models for schizophrenia

2002 • 117 citations

Haloperidol-induced tardive dyskinesia in monkeys

1976 • 117 citations

Continuous avoidance as a base-line for measuring behavioral effects of drugs

1962 • 116 citations

Neuroleptic-Induced Acute Extrapyramidal Syndromes and Tardive Dyskinesia

1993 • 104 citations

Effects of dopamine receptor antagonists on sucrose consumption and preference

1989 • 97 citations

Reversal of PCP-induced learning and memory deficits in the Morris’ water maze by sertindole and other antipsychotics

2007 • 84 citations

Effects of cannabinoid receptor ligands on psychosis-relevant behavior models in the rat

2003 • 80 citations

Effects of MK801 and neuroleptics on prepulse inhibition: re-examination in two strains of rats

2000 • 77 citations

Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice

2007 • 73 citations

Methods for Assessing the Validity of Animal Models of Human Psychopathology

2003 • 71 citations

Behavioural and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat

1982 • 70 citations

Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats—A preliminary investigation

2007 • 67 citations

Actions of Novel Antipsychotic Agents on Apomorphine-Induced PPI Disruption: Influence of Combined Serotonin 5-HT1A Receptor Activation and Dopamine D2 Receptor Blockade

2006 • 60 citations

Preclinical Behavioral Models for Predicting Antipsychotic Activity

2009 • 60 citations

Effects of the 5-HT6 receptor antagonist, SB-271046, in animal models for schizophrenia

2002 • 59 citations

ACP-103, a 5-Hydroxytryptamine 2A Receptor Inverse Agonist, Improves the Antipsychotic Efficacy and Side-Effect Profile of Haloperidol and Risperidone in Experimental Models

2007 • 59 citations

Nicotine blocks apomorphine‐induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic α₇ receptors

2004 • 56 citations

SSR181507, a putative atypical antipsychotic with dopamine D2 antagonist and 5-HT1A agonist activities: improvement of social interaction deficits induced by phencyclidine in rats

2004 • 54 citations

Quetiapine Prevents Anhedonia Induced by Acute or Chronic Stress

2007 • 51 citations

Effect of AD-5423 on animal models of schizophrenia: phencyclidine-induced behavioral changes in mice

2003 • 50 citations

Visual object processing in schizophrenia: evidence for an associative agnosic deficit

2002 • 47 citations

Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs

2008 • 44 citations

Animal Models of Negative Symptoms M100907 Antagonizes PCP-Induced Immobility in a Forced Swim Test in Mice

1999 • 41 citations

Ontogeny of Phencyclidine and Apomorphine-Induced Startle Gating Deficits in Rats

2000 • 40 citations

Developing New Drugs for Schizophrenia: From Animals to the Clinic

2008 • 26 citations

Animal models of acute drug-induced akathisia – a review

2000 • 26 citations

DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- oxoethyl)piperidine HBr], a potential antipsychotic agent: preclinical behavioral effects.

1992 • 23 citations

Maniement des medicaments psychotropes

1970 • 11 citations

Animal models of neuroleptic-induced acute dystonia.

1988 • 8 citations