Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

1996 • 1,906 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances

1997 • 991 citations

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias

1995 • 749 citations

Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation

1984 • 671 citations

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 660 citations

Prognostic Subgroups in B-Cell Chronic Lymphocytic Leukemia Defined by Specific Chromosomal Abnormalities

1990 • 616 citations

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization

1993 • 561 citations

PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

1991 • 454 citations

Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11 ; 14) chromosome translocation

1985 • 446 citations

11q Deletions Identify a New Subset of B-Cell Chronic Lymphocytic Leukemia Characterized by Extensive Nodal Involvement and Inferior Prognosis

1997 • 433 citations

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

1986 • 380 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

Characterization of a candidate bcl-1 gene.

1991 • 357 citations

PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma

1994 • 353 citations

Nonrandom chromosome abnormalities in lymphoma.

1983 • 327 citations

bcl-1, t(11;14), and mantle cell-derived lymphomas [editorial]

1991 • 310 citations

Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients

1996 • 291 citations

Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia

1997 • 270 citations

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia

1997 • 266 citations

Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia

1997 • 212 citations

REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma

1996 • 212 citations

Clustering of aberrations to specific chromosomes in human neoplasms

2009 • 211 citations

Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation

1980 • 201 citations

Association of bcl-1 rearrangements with lymphocytic lymphoma of intermediate differentiation

1990 • 196 citations

6q deletions define distinct clinico-pathologic subsets of non- Hodgkin's lymphoma

1993 • 190 citations

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.

1990 • 172 citations

Prognostic Importance of Cytogenetic Abnormalities in Patients with Chronic Lymphocytic Leukemia

1984 • 168 citations

Cytogenetic deletion maps of hematologic neoplasms: Circumstantial evidence for tumor suppressor Loci

1993 • 167 citations

DNA copy number changes in diffuse large B-cell lymphoma--comparative genomic hybridization study

1996 • 160 citations

Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method

1992 • 159 citations

Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma

1998 • 159 citations

Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology

1993 • 148 citations

Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.

1992 • 147 citations

p16 gene homozygous deletions in acute lymphoblastic leukemia

1995 • 147 citations

A radiation hybrid map of 506 STS markers spanning human chromosome 11

1994 • 146 citations

Prognostic information from cytogenetic analysis in chronic B- lymphocytic leukemia and leukemic immunocytoma

1985 • 143 citations

Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.3-923.1 in lymphoproliferative disorders.

1996 • 141 citations

13q deletions in lymphoid malignancies

1995 • 137 citations

High incidence of chromosomal imbalances and gene amplifications in the classical follicular variant of follicle center lymphoma

1996 • 136 citations

Is non-isotopic in situ hybridization finally coming of age?

1990 • 135 citations

Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene

1993 • 135 citations

Detection of amplified DNA sequences by reverse chromosome painting using genomic tumor DNA as probe

1993 • 131 citations

Cloning and Gene Mapping of the Chromosome 13q14 Region Deleted in Chronic Lymphocytic Leukemia

1997 • 130 citations

High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics

1993 • 127 citations

Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study

1991 • 120 citations

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

1984 • 118 citations

Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

1987 • 118 citations

In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: A cytogenetic and immunophenotypic study of 480 unselected newly diagnosed patients

1997 • 117 citations

Karyotypic evolution in CLL: identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease.

1995 • 117 citations

The proto-oncogene bcl-3 encodes an I kappa B protein.

1992 • 116 citations

Fluorescent in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia

1993 • 114 citations

Deletions and rearrangement of CDKN2 in lymphoid malignancy

1995 • 113 citations

BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study

1997 • 113 citations

Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia

1996 • 112 citations

Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies

1995 • 109 citations

BCL2 translocations in leukemias of mature B cells

1994 • 109 citations

Chromosome abnormalities involving band 13q14 in hematologic malignancies

1987 • 102 citations

Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.

1993 • 102 citations

Detailed Molecular Delineation of 13q14.3 Loss in B-Cell Chronic Lymphocytic Leukemia

1998 • 101 citations

A new characteristic karyotypic anomaly in lymphoproliferative disorders

1979 • 97 citations

Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients

1991 • 96 citations

Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria.

1995 • 94 citations

[22] Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization

1995 • 94 citations

Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias

1994 • 89 citations

Extra Chromosome 12 and Prognosis in Chronic Lymphocytic Leukaemia

1982 • 84 citations

Oncogene rearrangements in chronic B-cell leukemia

1991 • 82 citations

Estimation of aneuploidy levels in human spermatozoa using chromosome specific probes and in situ hybridisation

1984 • 81 citations

Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations.

1989 • 80 citations

Frequent clonal abnormalities of chromosome band 13q 14 in b‐cell chronic lymphocytic leukemia: Multiple clones, subclones, and nonclonal alterations in 82 midwestern patients

1992 • 80 citations

Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia

1981 • 80 citations

Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia.

1994 • 77 citations

Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia

1990 • 76 citations

The most common chromosome change in 86 chronic B cell or T cell tumors: A 14q32 translocation

1986 • 75 citations

Human chronic lymphocytic leukemia: Karyotypes in different lymphocyte populations

1979 • 75 citations

Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia

1990 • 75 citations

Cytogenetic and molecular abnormalitiesin chronic lymphocytic leukaemia

1994 • 73 citations

A 14;19 TRANSLOCATION IN B‐CELL CHRONIC LYMPHOCYTIC LEUKEMIA: A NEW RECURRING CHROMOSOME ABERRATION

1985 • 72 citations

Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders

1982 • 72 citations

Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study

1993 • 71 citations

Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23)

1994 • 69 citations

Retinoblastoma gene deletions in b‐cell chronic lymphocytic leukemia

1992 • 67 citations

Chromosome abnormalities of leukaemic B lymphocytes in chronic lymphocytic leukaemia

1980 • 60 citations

Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukaemia

1987 • 59 citations

Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia.

1994 • 59 citations

Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia

1996 • 54 citations

In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40.

1993 • 51 citations

Molecular Cloning, cDNA Sequence, and Chromosomal Assignment of the Human Radixin Gene and Two Dispersed Pseudogenes

1993 • 51 citations

A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia.

1989 • 50 citations

Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization

1993 • 49 citations

Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood cultures

1987 • 46 citations

Construction of a 780-kb PAC, BAC, and Cosmid Contig Encompassing the Minimal Critical Deletion Involved in B Cell Chronic Lymphocytic Leukemia at 13q14.3

1997 • 45 citations

Chromosome abnormalities in chronic lymphocytic leukemia revealed by TPA as a mitogen

1983 • 40 citations

Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridization.

1995 • 34 citations

Chromosome 13… new marker for B-cell chronic lymphocytic leukemia

2008 • 30 citations

Cytogenetic studies in chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia: a progress report.

1988 • 28 citations

Molecular Cytogenetic Analysis of RB-1 Deletions in Chronic B-Cell Leukemias

1994 • 27 citations

CDKN2 gene deletion is not found in chronic lymphoid leukaemias of B‐ and T‐cell origin but is frequent in acute lymphoblastic leukaemia

1995 • 19 citations

Lack of clonal BCRA2 gene deletion on chromosome 13in chronic lymphocytic leukaemia

1997 • 13 citations

Lack of 5′ BCL2 rearrangements in B-cell leukemia

1993 • 10 citations