Cytogenetic and molecular abnormalitiesin chronic lymphocytic leukaemia

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

1991 • 915 citations

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 660 citations

Prognostic Subgroups in B-Cell Chronic Lymphocytic Leukemia Defined by Specific Chromosomal Abnormalities

1990 • 616 citations

p53 mutation is associated with progression in follicular lymphomas

1993 • 394 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

The human MDM-2 oncogene is overexpressed in leukemias

1993 • 253 citations

Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells

1992 • 206 citations

6q deletions define distinct clinico-pathologic subsets of non- Hodgkin's lymphoma

1993 • 190 citations

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.

1990 • 172 citations

Prognostic Importance of Cytogenetic Abnormalities in Patients with Chronic Lymphocytic Leukemia

1984 • 168 citations

Mutations of p53 gene and their relation to disease progression in B- cell lymphoma

1992 • 166 citations

Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: a simple and sensitive method

1992 • 159 citations

Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: analysis by stage, immunophenotype, and morphology

1993 • 148 citations

Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: a report on 39 cases with cytogenetic analysis.

1992 • 147 citations

Chromosome aberrations in B-cell chronic lymphocytic leukemia

1990 • 144 citations

Prognostic information from cytogenetic analysis in chronic B- lymphocytic leukemia and leukemic immunocytoma

1985 • 143 citations

Evidence for a new tumour suppressor locus (DBM) in human B–cell neoplasia telomeric to the retinoblastoma gene

1993 • 135 citations

High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics

1993 • 127 citations

Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study

1991 • 120 citations

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

1984 • 118 citations

Molecular genetic demonstration of the diverse evolution of Richter's syndrome (chronic lymphocytic leukemia and subsequent large cell lymphoma)

1994 • 115 citations

Trisomy 12 in B Cells of Patients with B-Cell Chronic Lymphocytic Leukemia

1986 • 110 citations

BCL2 translocations in leukemias of mature B cells

1994 • 109 citations

Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: evidence for a role of an adjacent locus.

1993 • 102 citations

Chromosome abnormalities involving band 13q14 in hematologic malignancies

1987 • 102 citations

Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients

1991 • 96 citations

Extra Chromosome 12 and Prognosis in Chronic Lymphocytic Leukaemia

1982 • 84 citations

Oncogene rearrangements in chronic B-cell leukemia

1991 • 82 citations

Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations.

1989 • 80 citations

Frequent clonal abnormalities of chromosome band 13q 14 in b‐cell chronic lymphocytic leukemia: Multiple clones, subclones, and nonclonal alterations in 82 midwestern patients

1992 • 80 citations

Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia

1990 • 76 citations

Consistency of chromosomal aberrations in chronic B-lymphocytic leukemia. A longitudinal cytogenetic study of 41 patients

1988 • 74 citations

A 14;19 TRANSLOCATION IN B‐CELL CHRONIC LYMPHOCYTIC LEUKEMIA: A NEW RECURRING CHROMOSOME ABERRATION

1985 • 72 citations

Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study

1993 • 71 citations

The consistent 13q14 translocation breakpoint seen in chronic B-cell leukaemia (BCLL) involves deletion of the D13S25 locus which lies distal to the retinoblastoma predisposition gene.

1993 • 68 citations

Retinoblastoma gene deletions in b‐cell chronic lymphocytic leukemia

1992 • 67 citations

Non-radioactive in situ hybridization for the detection and monitoring of trisomy 12 in B-cell chronic lymphocytic leukaemia

1992 • 64 citations

Karyotypic evolution in B‐cell chronic lymphocytic leukaemia

1991 • 61 citations

Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukaemia

1987 • 59 citations

Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia.

1994 • 59 citations

Cytogenetic studies in 77 patients with chronic lymphocytic leukemia: correlations with clinical, immunologic, and phenotypic data.

1984 • 59 citations

bcl-2 gene expression in hematopoietic cell differentiation

1992 • 57 citations

Karyotypic stability in chronic B-cell leukemia

1988 • 54 citations

In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40.

1993 • 51 citations

B‐cell chronic lymphocytic leukaemia: Clonal chromosome abnormalities and prognosis in 89 cases

1989 • 51 citations

A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia.

1989 • 50 citations

Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood cultures

1987 • 46 citations

Molecular analyses of chromosome 12 in chronic lymphocytic leukemia.

1989 • 45 citations

Trisomy 12 in B‐cell chronic lymphocytic leukaemia: assessment of lineage restriction by simultaneous analysis of immunophenotype and genotype in interphase cells by fluorescence in situ hybridization

1994 • 43 citations

Chronic lymphocytic leukaemia treatment

1993 • 42 citations

6 Chronic lymphocytic leukaemia: Prognostic factors and natural history

1993 • 39 citations

Abnormal/normal metaphase ratio and prognosis in chronic B-lymphocytic leukemia

1985 • 29 citations

Cytogenetic evidence for clonal evolution in B-cell chronic lymphocytic leukemia

1986 • 27 citations

Interphase detection of trisomy 12 in B-cell chronic lymphocytic leukemia by fluorescence hybridization in situ.

1992 • 27 citations

Chromosomal translocation t(14;19) as indicated by bcl-3 rearrangement is a rare phenomenon in non-Hodgkin's lymphoma and chronic lymphocytic leukemia: a molecular genetic analysis of 176 cases.

1990 • 25 citations

Lack of MDM2 amplification in human leukaemia

1994 • 22 citations

Role of chromosomal abnormalities in chronic lymphocytic leukemia

1987 • 20 citations

Confirmation of Rb gene defects in B‐CLL clones and evidence for variable predominance of the Rb defective cells within the CLL clone

1993 • 19 citations

The origin of trisomy 12 in B-cell chronic lymphocytic leukemia

1988 • 18 citations

Chromosomal abnormalities in B-CLL.

1988 • 16 citations

Use of a retinoblastoma gene probe to investigate clonality in Richter's syndrome.

1993 • 12 citations

Karyotypes of 33 patients with clonal aberrations in chronic lymphocytic leukaemia. Review of 216 abnormal karyotypes in chronic lymphocytic leukaemia.

1989 • 10 citations

Chromosome studies in stimulated lymphocytes of 50 patients with B-cell chronic lymphocytic leukemia.

1992 • 10 citations

Lack of 5′ BCL2 rearrangements in B-cell leukemia

1993 • 10 citations

Improvement of cytogenetic results in B-cell chronic lymphocytic leukemia using immuno-purified leukemic cells.

1993 • 4 citations

Use of various mitogens and cell stimulation index in 21 patients with chronic lymphocytic leukaemia.

1989 • 2 citations