Shroom, a PDZ Domain–Containing Actin-Binding Protein, Is Required for Neural Tube Morphogenesis in Mice

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

1996 • 1,900 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

E-cadherin null mutant embryos fail to form a trophectoderm epithelium.

1994 • 920 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.

1995 • 702 citations

Lack of β-catenin affects mouse development at gastrulation

1995 • 700 citations

Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics

1996 • 667 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

twist is required in head mesenchyme for cranial neural tube morphogenesis.

1995 • 595 citations

Vinculin knockout results in heart and brain defects during embryonic development

1998 • 511 citations

Mena Is Required for Neurulation and Commissure Formation

1999 • 415 citations

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

1997 • 414 citations

PDZ Domains: Targeting signalling molecules to sub‐membranous sites

1997 • 411 citations

Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation

1998 • 403 citations

Mechanisms of neurulation: traditional viewpoint and recent advances

1990 • 392 citations

Cloning and growth of multipotential neural precursors: Requirements for proliferation and differentiation

1993 • 381 citations

The LIN-2/LIN-7/LIN-10 Complex Mediates Basolateral Membrane Localization of the C. elegans EGF Receptor LET-23 in Vulval Epithelial Cells

1998 • 366 citations

The embryonic development of mammalian neural tube defects

1990 • 337 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

MARCKS deficiency in mice leads to abnormal brain development and perinatal death.

1995 • 291 citations

A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.

1994 • 284 citations

Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

1996 • 273 citations

Vinculin Is Part of the Cadherin–Catenin Junctional Complex: Complex Formation between α-Catenin and Vinculin

1998 • 260 citations

Catenins as mediators of the cytoplasmic functions of cadherins

1993 • 249 citations

Protein-Protein Interaction of Zinc Finger LIM Domains with Protein Kinase C

1996 • 248 citations

Patterning of Neural Crest Derivatives in the Avian Embryo: in Vivo and in Vitro Studies

1993 • 243 citations

Neurulation: coming to closure

1997 • 228 citations

Loss of E-Cadherin-Dependent Cell-Cell Adhesion due to Mutation of the β-Catenin Gene in a Human Cancer Cell Line, HSC-39

1995 • 225 citations

Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins

1998 • 215 citations

An α- E-catenin gene trap mutation defines its function in preimplantation development

1997 • 214 citations

Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development

1997 • 190 citations

Characterization of an F-actin-binding domain in the cytoskeletal protein vinculin.

1994 • 154 citations

The role of microtubules and microfilaments in neurulation in Xenopus

1971 • 136 citations

Neurulation in the mouse: Manner and timing of neural tube closure

1989 • 115 citations

Bending of the neural plate during mouse spinal neurulation is independent of actin microfilaments

1999 • 114 citations

Promoter interactions in retrovirus vectors introduced into fibroblasts and embryonic stem cells

1991 • 95 citations

Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly.

1996 • 94 citations

Neural tube defects and abnormal brain development in F52-deficient mice.

1996 • 94 citations

Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (anencephaly).

1995 • 86 citations

Poorly Differentiated Colon Carcinoma Cell Lines Deficient in α-Catenin Expression Express High Levels of Surface E-cadherin but Lack Ca²⁺-Dependent Cell-Cell Adhesion

1993 • 80 citations

Defined concentrations of a posteriorizing signal are critical for MafB/Kreisler segmental expression in the hindbrain

1998 • 70 citations

Postimplantation mammalian embryos

1993 • 68 citations

Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity.

1992 • 49 citations

Ligand recruitment by vinculin domains in transfected cells

1997 • 43 citations

Renal Epithelial Protein (Apx) Is an Actin Cytoskeleton-regulated Na+ Channel

1996 • 34 citations

Cloning of a human homologue of the Xenopus Iaevis APX gene from the ocular albinism type 1 critical region

1995 • 33 citations

Mechanisms of Neurulation

2003 • 32 citations