A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane

1993 • 654 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation

1992 • 450 citations

A protein complex required for signal-sequence-specific sorting and translocation

1994 • 404 citations

Suppressor mutations that restore export of a protein with a defective signal sequence

1981 • 382 citations

Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore

1994 • 338 citations

RIBOSOME-MEMBRANE INTERACTION

1973 • 337 citations

A protein of the endoplasmic reticulum involved early in polypeptide translocation

1992 • 322 citations

The signal recognition particle in S. cerevisiae

1991 • 299 citations

The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide

1989 • 293 citations

The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation

1993 • 286 citations

Evolutionary conservation of components of the protein translocation complex

1994 • 283 citations

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer

1995 • 253 citations

Systematic probing of the environment of a translocating secretory protein during translocation through the ER membrane.

1994 • 237 citations

Signal peptides open protein-conducting channels in E. coli

1992 • 216 citations

Binding of ribosomes to the rough endoplasmic reticulum mediated by the Sec61p-complex.

1994 • 191 citations

Translocation of proteins across the endoplasmic reticulum

1993 • 176 citations

Transient involvement of signal recognition particle and its receptor in the microsomal membrane prior to protein translocation

1983 • 160 citations

Site-specific photocross-linking reveals that Sec61p and TRAM contact different regions of a membrane-inserted signal sequence.

1993 • 144 citations

In Vivo Function and Membrane Binding Properties Are Correlated for Escherichia coli lamB Signal Peptides

1985 • 130 citations

PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains.

1993 • 115 citations

Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum.

1995 • 113 citations

Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae.

1992 • 109 citations

Access of proteinase K to partially translocated nascent polypeptides in intact and detergent-solubilized membranes.

1989 • 88 citations

Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes.

1993 • 40 citations

Demonstration of Specific Receptors of the Rough Endoplasmic Membrane for the Signal Sequence of Carp Preproinsulin

1980 • 36 citations

DIDS (4,4'‐diisothiocyanatostilbene‐2,2'‐disulfonic acid) inhibits an early step of protein translocation across the mammalian ER membrane

1993 • 8 citations