Significance of 14-3-3 Self-Dimerization for Phosphorylation-dependent Target Binding

The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

1997 • 1,592 citations

14-3-3 Proteins: Structure, Function, and Regulation

2000 • 1,552 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine

1996 • 1,371 citations

Crystal structure of the zeta isoform of the 14-3-3 protein

1995 • 516 citations

Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding

1999 • 500 citations

14-3-3 Proteins: Active Cofactors in Cellular Regulation by Serine/Threonine Phosphorylation

2002 • 496 citations

Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

1995 • 473 citations

A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1998 • 471 citations

14-3-3 proteins: regulation of subcellular localization by molecular interference

2000 • 410 citations

Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex

2001 • 380 citations

14-3-3ζ Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove

1998 • 355 citations

Identification of the major phosphorylation sites of the Raf-1 kinase

1993 • 337 citations

Isolation of High-Affinity Peptide Antagonists of 14-3-3 Proteins by Phage Display

1999 • 305 citations

14-3-3 proteins; bringing new definitions to scaffolding

2001 • 298 citations

14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

2000 • 285 citations

Phosphoprotein Analysis Using Antibodies Broadly Reactive against Phosphorylated Motifs

2002 • 273 citations

Specific acidic proteins of the nervous system

1967 • 263 citations

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

1998 • 218 citations

Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways

2001 • 217 citations

14-3-3 (ϵ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner

1997 • 196 citations

[12] Cyanogen bromide cleavage and proteolytic peptide mapping of proteins immobilized to membranes

1991 • 170 citations

14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain

1997 • 155 citations

Interaction of 14-3-3 with a Nonphosphorylated Protein Ligand, Exoenzyme S ofPseudomonas aeruginosa

1999 • 154 citations

Calyculin A-induced Vimentin Phosphorylation Sequesters 14-3-3 and Displaces Other 14-3-3 Partners in Vivo

2000 • 149 citations

Raf-1 Kinase and Exoenzyme S Interact with 14-3-3ζ through a Common Site Involving Lysine 49

1997 • 147 citations

14-3-3 Is Phosphorylated by Casein Kinase I on Residue 233

1997 • 146 citations

14-3-3 proteins in neuronal development and function

1998 • 145 citations

Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif

1997 • 135 citations

A Novel Sphingosine-dependent Protein Kinase (SDK1) Specifically Phosphorylates Certain Isoforms of 14-3-3 Protein

1998 • 130 citations

Yeast 14‐3‐3 proteins

2006 • 122 citations

Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase

2000 • 104 citations

Mutations in the Hydrophobic Surface of an Amphipathic Groove of 14-3-3ζ Disrupt Its Interaction with Raf-1 Kinase

1998 • 104 citations

Purification, Properties, and Immunohistochemical Localisation of Human Brain 14‐3‐3 Protein

1982 • 98 citations

Identification of the 14.3.3 ζ Domains Important for Self-association and Raf Binding

1995 • 93 citations

Identification of the Site of Interaction of the 14-3-3 Protein with Phosphorylated Tryptophan Hydroxylase

1995 • 93 citations

Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population.

2000 • 92 citations

Identification of a Novel Interaction of 14-3-3 with p190RhoGEF

2001 • 77 citations

The Signal Modulator Protein-14-3-3 Ts a Target of Sphingosine-Dependent or N,N-Dimethylsphingosine-Dependent Kinase in 3T3(A31) Cells

1995 • 65 citations

14-3-3 ζ Protein Binds to the Carboxyl Half of Mouse Wee1 Kinase

1997 • 61 citations

Identification of Raf‐1 Ser⁶²¹ kinase activity from NIH 3T3 cells as AMP‐activated protein kinase

1997 • 61 citations

A Novel Ligand-binding Site in the ζ-Form 14-3-3 Protein Recognizing the Platelet Glycoprotein Ibα and Distinct from the c-Raf-binding Site

1998 • 56 citations

Structure and Sites of Phosphorylation of 14-3-3 Protein: Role in Coordinating Signal Transduction Pathways

1997 • 51 citations

Yeast 14‐3‐3 proteins

2001 • 47 citations

The 14‐3‐3 protein binds its target proteins with a common site located towards the C‐terminus

1997 • 41 citations

Exoenzyme S binds its cofactor 14-3-3 through a non-phosphorylated motif

2002 • 27 citations

Phosphorylation-independent interaction between 14-3-3 protein and the plant plasma membrane H+-ATPase

2002 • 22 citations