Directed evolution of a protein: selection of potent neutrophil elastase inhibitors displayed on M13 fusion phage.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Filamentous Fusion Phage: Novel Expression Vectors That Display Cloned Antigens on the Virion Surface

1985 • 3,886 citations

Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries.

2004 • 2,484 citations

Phage antibodies: filamentous phage displaying antibody variable domains

1990 • 2,346 citations

Searching for Peptide Ligands with an Epitope Library

1990 • 2,080 citations

Peptides on phage: a vast library of peptides for identifying ligands.

1990 • 928 citations

Random Peptide Libraries: a Source of Specific Protein Binding Molecules

1990 • 910 citations

Antibody-selectable filamentous fd phage vectors: affinity purification of target genes

1988 • 863 citations

Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.

1979 • 602 citations

Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol)

1989 • 544 citations

Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

1991 • 415 citations

Hormone phage: An enrichment method for variant proteins with altered binding properties

1990 • 360 citations

Pancreatic trypsin inhibitor. 2. Reaction with trypsin

1953 • 292 citations

Multiple display of foreign peptides on a filamentous bacteriophage

1991 • 288 citations

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges

1972 • 251 citations

Structure, function, and control of neutrophil proteinases

1988 • 226 citations

Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases

1985 • 86 citations

Design, construction and function of a multicopy display vector using fusions to the major coat protein of bacteriophage M13

1991 • 73 citations

Mutants of Bovine Pancreatic Trypsin Inhibitor Lacking Cysteines 14 and 38 Can Fold Properly

1987 • 65 citations

Biosynthesis, Processing, and Evolution of Bovine Pancreatic Trypsin Inhibitor

1987 • 54 citations

Production of native, correctly folded bovine pancreatic trypsin inhibitor by Escherichia coli.

1986 • 52 citations

Preparation of chemically ‘mutated’ aprotinin homologues by semisynthesis

1988 • 35 citations