Preparation of chemically ‘mutated’ aprotinin homologues by semisynthesis

Methods of Enzymatic Analysis

1975 • 20,446 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

Methods of enzymatic analysis

1985 • 3,497 citations

A gas-liquid solid phase peptide and protein sequenator.

1981 • 2,238 citations

Protein Inhibitors of Proteinases

1980 • 2,220 citations

[27] The cyanogen bromide reaction

1967 • 784 citations

Selective oxidation of methionine residues in proteins

1975 • 346 citations

Pancreatic trypsin inhibitor. 2. Reaction with trypsin

1953 • 292 citations

The Basic Trypsin Inhibitor of Bovine Pancreas

1963 • 289 citations

THE PEPTIDES: Analysis, Synthesis, Biology

1981 • 274 citations

Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges

1972 • 251 citations

Modern methods in protein chemistry

1983 • 221 citations

Ovomucoid third domains from 100 avian species: isolation, sequences, and hypervariability of enzyme-inhibitor contact residues

1987 • 202 citations

THE PEPTIDES: Analysis, Synthesis, Biology

1979 • 158 citations

In vivo significance of kinetic constants of protein proteinase inhibitors

1984 • 150 citations

The possible role of neutrophil proteinases in damage to articular cartilage

1978 • 142 citations

The Disulfide Linkages in Kallikrein Inactivator of Bovine Lung

1966 • 91 citations

Advantages of picrate fixation for staining polypeptides in polyacrylamide gels

1986 • 71 citations

Immunofluorescence Studies Indicate that the Basic Trypsin-Kallikrein-Inhibitor of Bovine Organs (Trasylol) Originates from Mast Cells

1979 • 67 citations

Stopped-flow kinetics of the resynthesis of the reactive site peptide bond in kallikrein inhibitor (Kunitz) by β-trypsin

1978 • 56 citations

Replacement of Lysine by Arginine, Phenylalanine and Tryptophan in the Reactive Site of the Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) and Change of the Inhibitory Properties

1976 • 56 citations

Neue Veresterungsmethoden in der Peptidchemie, VIII. Darstellung von tert.‐Butylestern freier Aminosäuren

1961 • 54 citations

Biological Functions of Proteinases

1979 • 41 citations

Preparation and Characterization of the Active Derivative of Bovine Trypsin‐Kallikrein Inhibitor (Kunitz) with the Reactive Site Lysine‐15 – Alanine‐16 Hydrolyzed

1976 • 41 citations

Separation of the Human Leucocy te Enzymes. Alanine Aminopeptidase, Cathepsin G, Collagenase, Elastase and Myeloperoxidase

1982 • 40 citations

Studies on Soybean Trypsin Inhibitors

1978 • 37 citations

Replacements, Insertions, and Modifications of Amino Acid Residues in the Reactive Site of Soybean Trypsin Inhibitor (Kunitz)

1974 • 34 citations

A synthetic operon containing 14 bovine pancreatic trypsin inhibitor genes is expressed in E. coli.

1986 • 34 citations

Semisynthetic engineering of proteinase inhibitor homologues

1987 • 32 citations

Racemization of free and protein‐bound amino acids in strong mineral acid

1981 • 30 citations

Recombinant DNA-derived forms of human alpha 1-proteinase inhibitor. Studies on the alanine 358 and cysteine 358 substituted mutants.

1986 • 27 citations

The inhibition of human leukocyte elastase by basic pancreatic trypsin inhibitor

1978 • 23 citations

Chemical Substitutions of the Reactive Site Leucine Residue in Soybean Bowman-Birk Proteinase Inhibitor with Other Amino Acids1

1980 • 21 citations

Synthesis and characterization of a pancreatic trypsin inhibitor homolog and a model inhibitor

1977 • 21 citations

Studies on the basic trypsin inhibitor of bovine pancreas and its interaction with trypsin

1967 • 20 citations

Chemical synthesis, molecular cloning and expression of gene coding for a Bowman-Birk-type proteinase inhibitor

1987 • 20 citations

“Chemical Mutation” by Amino Acid Exchange in the Reactive Site of a Proteinase Inhibitor and Alteration or Its Inhibitor Specifity

1981 • 18 citations

Chemical Replacement of P1' Arginine Residue at the First Reactive Site of Peanut Protease Inhibitor B-III

1987 • 18 citations

Synthesis, Cloning and Expression of Recombinant Aprotinin

1987 • 17 citations

Covalent hybrids of ovomucoid third domains made from one synthetic and one natural peptide chain

1987 • 15 citations

Neue Veresterungsmethoden in der Peptidchemie, VI. ω-Ester der Asparaginsäure und Glutaminsäure

1961 • 10 citations

Reactive Site Cleavage, Thermodynamic Control Resynthesis, and Properties of Chemically Derivatized Trypsin-Kallikrein-Inhibitors

1974 • 10 citations

Chemical Replacement of P1‘ Serine Residue at the Second Reactive Site of Soybean Protease Inhibitor C-II1

1987 • 6 citations