CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

1997 • 6,760 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

1994 • 4,563 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

2002 • 1,335 citations

Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone.

2002 • 979 citations

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

2000 • 760 citations

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide

2003 • 758 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 642 citations

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

2000 • 606 citations

The chemokine SDF-1 stimulates integrin-mediated arrest of CD34+ cells on vascular endothelium under shear flow

1999 • 569 citations

Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

2003 • 544 citations

Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines

2002 • 518 citations

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow

2004 • 491 citations

The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice

2002 • 461 citations

Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo

2003 • 440 citations

The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.

2003 • 431 citations

Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.

2002 • 428 citations

Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression.

2000 • 422 citations

A Possible Role for CXCR4 and Its Ligand, the CXC Chemokine Stromal Cell-Derived Factor-1, in the Development of Bone Marrow Metastases in Neuroblastoma

2001 • 419 citations

CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival

2002 • 369 citations

Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival

2000 • 365 citations

Long-Term Hematopoietic Stem Cells Require Stromal Cell-Derived Factor-1 for Colonizing Bone Marrow during Ontogeny

2003 • 350 citations

Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1

2002 • 342 citations

Rapid and efficient homing of human CD34+CD38−/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice

2001 • 311 citations

Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism

2002 • 276 citations

CXCR4/CXCL12 expression and signalling in kidney cancer

2002 • 255 citations

Acute myeloid leukemia cells are protected from spontaneous and drug-induced apoptosis by direct contact with a human bone marrow stromal cell line (HS-5)

2001 • 224 citations

The SDF‐1‐CXCR4 Axis Stimulates VEGF Secretion and Activates Integrins but does not Affect Proliferation and Survival in Lymphohematopoietic Cells

2001 • 221 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells.

2002 • 212 citations

CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma.

2002 • 203 citations

High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia

2001 • 198 citations

A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

2003 • 193 citations

Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

2003 • 187 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells

2002 • 185 citations

Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro

2003 • 180 citations

CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells

2001 • 165 citations

Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice

1999 • 160 citations

Enhancement of intracellular signaling associated with hematopoietic progenitor cell survival in response to SDF-1/CXCL12 in synergy with other cytokines

2002 • 151 citations

Functional response of leukaemic blasts to stromal cell‐derived factor‐1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia

2000 • 146 citations

The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

1998 • 136 citations

Human CD34(+) cells express CXCR4 and its ligand stromal cell-derived factor-1. Implications for infection by T-cell tropic human immunodeficiency virus.

1999 • 125 citations

Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow

1999 • 123 citations

In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation

2001 • 120 citations

Selective Transendothelial Migration of Hematopoietic Progenitor Cells: A Role in Homing of Progenitor Cells

1999 • 111 citations

Human CD34+ Cells Express CXCR4 and Its Ligand Stromal Cell–Derived Factor-1. Implications for Infection by T-Cell Tropic Human Immunodeficiency Virus

1999 • 108 citations

Migratory behavior of leukemic cells from acute myeloid leukemia patients

2002 • 100 citations

Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms

1993 • 92 citations

Marrow matrix metalloproteinases (MMPs) and tissue inhibitors of MMP in acute leukaemia: potential role of MMP‐9 as a surrogate marker to monitor leukaemic status in patients with acute myelogenous leukaemia

2002 • 91 citations

Acute Myeloid Leukemia

2002 • 78 citations

Plasma Levels of SDF-1 and Expression of SDF-1 Receptor on CD34+ Cells in Mobilized Peripheral Blood of Non-Hodgkin's Lymphoma Patients

2001 • 75 citations

Growth Characteristics of Acute Myelogenous Leukemia Progenitors That Initiate Malignant Hematopoiesis in Nonobese Diabetic/Severe Combined Immunodeficient Mice

1999 • 60 citations

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

2000 • 56 citations

Production of Stromal Cell-Derived Factor-1 (SDF-1)and Expression of CXCR4 in Human Bone Marrow Endothelial Cells

2003 • 39 citations

Enumeration of bone marrow ‘homing’ haemopoietic stem cells from G-CSF-mobilised normal donors and influence on engraftment following allogeneic transplantation

2001 • 34 citations

Human acute myeloid leukaemia cells express adhesion proteins and bind to bone marrow fibroblast monolayers and extracellular matrix proteins.

1993 • 34 citations

Significance of increasing adhesion of cord blood hematopoietic cells and a new method: Platelet microparticles

2003 • 20 citations

Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms

1993 • 10 citations

Selective Transendothelial Migration of Hematopoietic Progenitor Cells: A Role in Homing of Progenitor Cells

1999 • 9 citations