Problems and solutions in myoblast transfer therapy

Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals

1987 • 2,353 citations

Renal and Extrarenal Effects of Gum Arabic (Acacia Senegal) - What Can be Learned from Animal Experiments?

2013 • 2,289 citations

Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

2001 • 1,102 citations

Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells

2000 • 878 citations

MyoD is required for myogenic stem cell function in adult skeletal muscle.

1996 • 705 citations

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function

1998 • 700 citations

Clonal Isolation of Muscle-Derived Cells Capable of Enhancing Muscle Regeneration and Bone Healing

2000 • 628 citations

Duchenne muscular dystrophy: Deficiency of dystrophin at the muscle cell surface

1988 • 617 citations

Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice

1999 • 571 citations

Dynamics of Myoblast Transplantation Reveal a Discrete Minority of Precursors with Stem Cell–like Properties as the Myogenic Source

1999 • 501 citations

Adeno-associated virus vector carrying human minidystrophin genes effectively ameliorates muscular dystrophy in mdx mouse model

2000 • 467 citations

Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy

1998 • 464 citations

The human natural killer cell immune synapse

1999 • 418 citations

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse

2000 • 371 citations

Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies

1989 • 343 citations

Results of a Triple Blind Clinical Study of Myoblast Transplantations without Immunosuppressive Treatment in Young Boys with Duchenne Muscular Dystrophy

1993 • 335 citations

Natural killer cell receptors

1995 • 314 citations

Evidence for a myogenic stem cell that is exhausted in dystrophic muscle

2000 • 289 citations

Interleukin-12

1994 • 285 citations

The Transition from Proliferation to Differentiation Is Delayed in Satellite Cells from Mice Lacking MyoD

1999 • 265 citations

Rapid death of injected myoblasts in myoblast transfer therapy

1996 • 265 citations

The α7β1 integrin in muscle development and disease

1999 • 264 citations

Helper (CD4+) and Cytotoxic (CD8+) T Cells Promote the Pathology of Dystrophin-Deficient Muscle

2001 • 252 citations

Chemotaxis of skeletal muscle satellite cells

1997 • 226 citations

Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation.

2000 • 223 citations

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

1996 • 195 citations

Massive Idiosyncratic Exon Skipping Corrects the Nonsense Mutation in Dystrophic Mouse Muscle and Produces Functional Revertant Fibers by Clonal Expansion

2000 • 195 citations

Utrophin: A Structural and Functional Comparison to Dystrophin

1996 • 168 citations

Myogenic stem cells for the therapy of primary myopathies: wishful thinking or therapeutic perspective?

2000 • 157 citations

Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice.

1997 • 154 citations

Why Do Cultured Transplanted Myoblasts Die in Vivo? DNA Quantification Shows Enhanced Survival of Donor Male Myoblasts in Host Mice Depleted of CD4⁺ and CD8⁺ Cells or NK1.1⁺ Cells

2000 • 140 citations

Muscle regeneration: molecular aspects and therapeutic implications

1999 • 135 citations

Evidence That Tumor Necrosis Factor Participates in the Regulation of Muscle Proteolysis During Sepsis

1992 • 133 citations

Macrophage invasion does not contribute to muscle membrane injury during inflammation

1999 • 128 citations

Macrophages and dendritic cells in normal and regenerating murine skeletal muscle

1997 • 128 citations

Expression of Laminin α1, α2, α4, and α5 Chains, Fibronectin, and Tenascin-C in Skeletal Muscle of Dystrophic 129ReJdy/dyMice

1999 • 123 citations

Tumor Necrosis Factor Inhibits Human Myogenesis In Vitro

1988 • 122 citations

Dystrophic Muscle in Mice Chimeric for Expression of α5 Integrin

1998 • 114 citations

A role for mast cells in the progression of Duchenne muscular dystrophy?

1994 • 108 citations

Control of inflammatory damage by anti-LFA-l: Increase success of myoblast transplantation

1997 • 106 citations

Eosinophilia of Dystrophin-Deficient Muscle Is Promoted by Perforin-Mediated Cytotoxicity by T Cell Effectors

2000 • 103 citations

Feasibility, Safety, and Efficacy of Myoblast Transfer Therapy on Duchenne Muscular Dystrophy Boys

1992 • 102 citations

Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G

2000 • 100 citations

Myotube Formation is Delayed but not Prevented in MyoD-deficient Skeletal Muscle: Studies in Regenerating Whole Muscle Grafts of Adult Mice

2000 • 93 citations

Successful histocompatible myoblast transplantation in dystrophin-deficient mdx mouse despite the production of antibodies against dystrophin.

1995 • 88 citations

Natural killer cell receptors

1997 • 88 citations

High-Level Dystrophin Expression after Adenovirus-Mediated Dystrophin Minigene Transfer to Skeletal Muscle of Dystrophic Dogs: Prolongation of Expression with Immunosuppression

1998 • 82 citations

Lymphocyte infiltration following allo‐and xenomyoblast transplantation in mdx mice

1995 • 80 citations

Immunobiology and the Future of Myoblast Transfer Therapy

2000 • 79 citations

Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for Duchenne muscular dystrophy

2000 • 74 citations

A DUAL-MARKER SYSTEM FOR QUANTITATIVE STUDIES OF MYOBLAST TRANSPLANTATION IN THE MOUSE1

1997 • 69 citations

Aging and stress-induced changes in complement activation and neutrophil mobilization

1994 • 68 citations

Exposure to Tissue Culture Conditions Can Adversely Affect Myoblast Behavior in Vivo in Whole Muscle Grafts: Implications for Myoblast Transfer Therapy

2000 • 68 citations

Transient immunosuppressive treatment leads to long-term retention of allogeneic myoblasts in hybrid myofibers.

1994 • 68 citations

Adenovirus-mediated dystrophin minigene transfer improves muscle strength in adult dystrophic (MDX) mice

1998 • 67 citations

Tumor necrosis factor inhibits human myogenesis in vitro.

1988 • 66 citations

Cellular and molecular reactions in mouse muscles after myoblast implantation

1995 • 64 citations

Differential effects of dystrophin and utrophin gene transfer in immunocompetent muscular dystrophy (mdx) mice

2000 • 58 citations

Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture.

1992 • 54 citations

Age-Related Conversion of Dystrophin-Negative to -Positive Fiber Segments of Skeletal but not Cardiac Muscle Fibers in Heterozygote mdx Mice

1990 • 51 citations

Transplantation of myoblasts from a transgenic mouse overexpressing dystrophin produced only a relatively small increase of dystrophin-positive membrane

1998 • 50 citations

Prior culture with concanavalin A increases intramuscular migration of transplanted myoblast

1998 • 50 citations

Human skeletal myoblasts spontaneously activate allogeneic complement but are resistant to killing.

1996 • 47 citations

Efficient Utrophin Expression Following Adenovirus Gene Transfer in Dystrophic Muscle

1998 • 44 citations

Intramuscular Migration of Myoblasts Transplanted after Muscle Pretreatment with Metalloproteinases

2000 • 43 citations

Increased Myogenic Potential and Fusion of Matrilysin-Expressing Myoblasts Transplanted in Mice

1999 • 43 citations

Successful Transplantation of Genetically Corrected DMD Myoblasts Followingex VivoTransduction with the Dystrophin Minigene

1998 • 40 citations

Quantitative morphology of mast cells in skeletal muscle of normal and genetically dystrophic mice

1997 • 38 citations

Myoblast transplantation in non-dystrophic dog

1998 • 38 citations

A potential alternative strategy for myoblast transfer therapy: The use of sliced muscle grafts

1996 • 36 citations

Expression of human dystrophin following the transplantation of genetically modified mdx myoblasts

1998 • 35 citations

Control of Inflammatory Damage by Anti-Lfa-1: Increase Success of Myoblast Transplantation

1997 • 32 citations

Chemotaxis in myogenesis

1996 • 31 citations

Differential expression of dystrophin, utrophin, and dystrophin-associated proteins in human muscle culture

2000 • 31 citations

Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy

1997 • 29 citations

ROLE OF NON-MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS IN THE REJECTION OF TRANSPLANTED MYOBLASTS1

1997 • 28 citations

Enhanced migration and fusion of donor myoblasts in dystrophic and normal host muscle

2000 • 26 citations

Transplantation of Normal and DMD Myoblasts Expressing the Telomerase Gene in SCID Mice

2000 • 26 citations

Complement deposition and cell death after myoblast transplantation

1998 • 25 citations

Successive injections in MDX mice of myoblasts grown with bFGF

1996 • 22 citations

IMMUNOSUPPRESSION WITH MONOCLONAL ANTIBODIES AND CTLA4-Ig AFTER MYOBLAST TRANSPLANTATION IN MICE

1996 • 22 citations

Dynamic restoration of dystrophin to dystrophin-deficient myotubes

2001 • 21 citations

Complement and myoblast transfer therapy: Donor myoblast survival is enhanced following depletion of host complement C3 using cobra venom factor, but not in the absence of C5

2001 • 19 citations

The NO way to increase muscular utrophin expression?

2000 • 16 citations

A Potential Alternative Strategy for Myoblast Transfer Therapy: The use of Sliced Muscle Grafts

1996 • 16 citations

Complement Deposition and Cell Death after Myoblast Transplantation

1998 • 15 citations

The ‘Fantastic Voyage’ of muscle progenitor cells

1998 • 11 citations

Increased survival, movement and fusion of myoblasts from sliced muscle grafts into skeletal muscle of T-cell depleted and tolerised host mice

1997 • 8 citations

Myoblast Transfer Therapy in the New Millennium

2000 • 8 citations

Unsequivocal evidence of donor myoblasts

1997 • 2 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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