Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase

2004 • 1,968 citations

Mechanism by which metformin reduces glucose production in type 2 diabetes.

2000 • 1,017 citations

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

1989 • 799 citations

Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism

2006 • 675 citations

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

2000 • 623 citations

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 618 citations

Biguanides and NIDDM

1992 • 601 citations

Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation

2003 • 513 citations

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase

1994 • 482 citations

Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway

2001 • 346 citations

Anti-lipolytic Action of AMP-activated Protein Kinase in Rodent Adipocytes

2005 • 317 citations

cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior.

1985 • 302 citations

Analysis of Lipolytic Protein Trafficking and Interactions in Adipocytes

2006 • 296 citations

Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis In 3T3-L1 Adipocytes

2003 • 287 citations

Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes

2006 • 286 citations

Involvement of a cGMP-dependent Pathway in the Natriuretic Peptide-mediated Hormone-sensitive Lipase Phosphorylation in Human Adipocytes

2003 • 258 citations

Role of PAT proteins in lipid metabolism

2005 • 258 citations

Post-translational Regulation of Adipose Differentiation-related Protein by the Ubiquitin/Proteasome Pathway

2005 • 250 citations

On the Control of Lipolysis in Adipocytes

1999 • 245 citations

Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production

1994 • 217 citations

Involvement of Organic Cation Transporter 1 in the Lactic Acidosis Caused by Metformin

2003 • 184 citations

cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators.

1985 • 168 citations

Beta-adrenoceptor expression in human fat cells from different regions.

1990 • 156 citations

Effects of troglitazone and metformin on glucose and lipid metabolism

1997 • 110 citations

Control of endogenous phosphorylation of the major cAMP-dependent protein kinase substrate in adipocytes by insulin and beta-adrenergic stimulation.

1990 • 107 citations

Degradation of perilipin is mediated through ubiquitination-proteasome pathway

2006 • 104 citations

Maximal β3-Adrenergic Regulation of Lipolysis Involves Src and Epidermal Growth Factor Receptor-dependent ERK1/2 Activation

2006 • 75 citations

Further Evidence for a Central Role of Adipose Tissue in the Antihyperglycemic Effect of Metformin

1998 • 72 citations

Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin.

1991 • 68 citations

Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation

2006 • 66 citations

Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-α or isoproterenol

2006 • 63 citations

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

1994 • 57 citations

Attenuation of Adipocyte Triacylglycerol Hydrolase Activity Decreases Basal Fatty Acid Efflux

2007 • 52 citations

Bioavailability of metformin. Comparison of solution, rapidly dissolving tablet, and three sustained release products.

1986 • 49 citations

Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro.

1984 • 44 citations

Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-α in Primary Rat Adipocytes

2007 • 43 citations

Hormonal Control of Reversible Translocation of Perilipin B to the Plasma Membrane in Primary Human Adipocytes

2006 • 36 citations

Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes

2006 • 35 citations

The Effect of Metformin on Adipose Tissue Metabolism and Peripheral Blood Flow in Subjects With NIDDM

1996 • 34 citations

Metformin inhibits catecholamine‐stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study

1999 • 25 citations