Zn⁺⁺ inhibits both tumor necrosis factor‐mediated DNA fragmentation and cytolysis

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Secretory products of macrophages.

1987 • 2,670 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Death and the cell

1986 • 616 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.

1981 • 160 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.

1988 • 124 citations

Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines.

1987 • 124 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Tumor necrosis factor as effector molecule in monocyte mediated cytotoxicity.

1986 • 89 citations

Protection from tumor necrosis factor cytotoxicity by protease inhibitors

1987 • 75 citations

Tumor necrosis factor: receptors on hematopoietic cells

1987 • 68 citations

A Rapid Assay for Cytotoxicity of Unstimulated Human Monocytes23

1984 • 55 citations

Natural cytotoxic cells and tumor necrosis factor activate similar lytic mechanisms.

1987 • 34 citations

Tumor necrosis factor: receptors on hematopoietic cells

1987 • 30 citations

Rapid killing of actinomycin D-treated tumor cells by human monocytes. II. Cytotoxicity is independent of secretion of reactive oxygen intermediates and is suppressed by protease inhibitors.

1985 • 30 citations

Impaired oxidative burst does not affect human monocyte tumoricidal activity.

1985 • 15 citations

Cytolysis of Actinomycin D-Treated Target Cells by Cell-Free Supernatants from Human Monocytes

1986 • 6 citations

Human Monocyte-Released Cytotoxic Factor: Effect on Various Cellular Functions, and Dependency of Cytolysis on Various Metabolic Processes

1986 • 6 citations