Biological effects of recombinant human tumor necrosis factor and its novel muteins on tumor and normal cell lines.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

1986 • 674 citations

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

1984 • 638 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.

1985 • 430 citations

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

1984 • 313 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

Site-specific mutagenesis of the human fibroblast interferon gene.

1984 • 193 citations

Tumour-necrosis factor from the rabbit. I. Mode of action, specificity and physicochemical properties

1978 • 172 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

Cytotoxic activity of tumor necrosis factor (TNF) on human cancer cells in vitro.

1981 • 113 citations

Stimulation of RNA Synthesis in L-929 Cells by Rabbit Tumor Necrosis Factor

1979 • 81 citations

Studies of structure-activity relationships of human interleukin-2.

1986 • 61 citations

Lymphocyte in vitro cytotoxicity: Mechanism of human lymphotoxin-induced target cell destruction

1973 • 52 citations

Increase of vulnerability to lymphotoxin in cells infected by vesicular stomatitis virus and its further augmentation by interferon

1985 • 49 citations

A single amino acid change in IFN-β1 abolishes its antiviral activity

1981 • 43 citations

Enhanced release of lymphotoxins by interferon-treated cells

1983 • 20 citations

[21] Site-specific mutagenesis to modify the human tumor necrosis factor gene

1987 • 9 citations