Different functions of the platelet-derived growth factor-alpha and -beta receptors for the migration and proliferation of cultured baboon smooth muscle cells.

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

1983 • 1,441 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

1992 • 681 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

1988 • 481 citations

PDGF ligand and receptor gene expression during repair of arterial injury.

1990 • 431 citations

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

1994 • 414 citations

Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery.

1990 • 314 citations

Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes.

1990 • 263 citations

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.

1992 • 259 citations

Regulation and role of PDGF receptor a-subunit expression during embryogenesis

1992 • 239 citations

Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets

1990 • 226 citations

Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor

1989 • 216 citations

Selective expression of PDGF A and its receptor during early mouse embryogenesis

1990 • 215 citations

Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation

1991 • 196 citations

Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation.

1992 • 183 citations

Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.

1992 • 169 citations

Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells.

1990 • 155 citations

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

1989 • 137 citations

Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β

1989 • 136 citations

Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons. Association in vivo of platelet-derived growth factor mRNA and protein with cellular proliferation.

1991 • 122 citations

Regulatory effects of platelet-derived growth factor-AA homodimer on migration of vascular smooth muscle cells

1992 • 119 citations

Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, nilvadipine

1988 • 106 citations

Platelet-Derived Growth Factor

1987 • 85 citations

Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions

1993 • 79 citations

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

1989 • 78 citations

Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: association with overexpression of PDGF β‐receptors

1993 • 72 citations

Basic fibroblast growth factor modulates the mitogenic potency of the platelet-derived growth factor (PDGF) isoforms by specific upregulation of the PDGF alpha receptor in vascular smooth muscle cells.

1992 • 71 citations

Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells.

1993 • 69 citations

Platelet-derived growth factor isoforms decrease insulin-like growth factor I gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4.

1992 • 63 citations

Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the alpha receptor-specific up-regulation

1991 • 61 citations

Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly.

1993 • 59 citations

Platelet-Derived Growth Factor Receptor: Current Views of the Two-Subunit Model

1990 • 58 citations

Angiotensin II‐induced vascular smooth muscle cell hypertrophy: PDGF A‐chain mediates the increase in cell size

1993 • 56 citations

Platelet-derived growth factor activity and mRNA expression in healing vascular grafts in baboons

1992 • 54 citations

Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma

1993 • 49 citations

Expressions of the low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes are stimulated by recombinant platelet-derived growth factor isomers.

1991 • 49 citations

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.

1991 • 49 citations

Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB.

1991 • 48 citations

Expression of PDGF α- and β-receptors in Rat Arterial Smooth Muscle Cells is Phenotype and Growth State Dependent

1990 • 44 citations

Platelet-derived growth factor (PDGF) alpha receptor activation modulates the calcium mobilizing activity of the PDGF beta receptor in Balb/c3T3 fibroblasts.

1992 • 42 citations

Mitogenic activity of interferon gamma on growth-arrested human vascular smooth muscle cells.

1992 • 35 citations

Purification and characterization of an autocrine migration factor for vascular smooth muscle cells (SMC), SMC-derived migration factor

1993 • 34 citations

Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer.

1990 • 31 citations

The induction of early response genes in rat smooth muscle cells by PDGF‐AA is not sufficient to stimulate DNA‐synthesis

1993 • 31 citations

Platelet-derived growth factor increases the turnover of GTP/GDP on ras in permeabilized fibroblasts.

1993 • 26 citations

Transcriptional control of the platelet-derived growth factor subunit genes.

1993 • 25 citations

Secretion of a potent new migration factor for smooth muscle cells (SMC) by cultured SMC

1991 • 24 citations

ANG II- or AVP-induced increases in protein synthesis are not dependent on autocrine secretion of PDGF-AA

1993 • 23 citations

Differential induction of the c‐fos promoter through distinct PDGF receptor‐mediated signaling pathways

1992 • 16 citations

Deletion or Substitution within the a Platelet-Derived Growth Factor Receptor Kinase Insert Domain: Effects on Functional Coupling with Intracellular Signaling Pathways

1991 • 9 citations

Comparison of PDGF-AA- and PDGF-BB-Induced Phosphoinositide Formation in Human and Mouse Fibroblasts

1994 • 5 citations

Interleukin-1 enhances the response of osteoblasts to platelet-derived growth factor through the α receptor-specific up-regulation

1993 • 3 citations