Nelfinavir Mesylate: A Protease Inhibitor

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1998 • 1,109 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

1994 • 526 citations

Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors

1991 • 366 citations

Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

1995 • 226 citations

Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

1994 • 217 citations

Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease

1996 • 209 citations

Characterization of human immunodeficiency virus type 1 mutantswith decreased sensitivity to proteinase inhibitor Ro 31-8959

1995 • 190 citations

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

1994 • 172 citations

In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease.

1993 • 129 citations

Current Knowledge and Future Prospects for the Use of HIV Protease Inhibitors

1996 • 129 citations

Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor

1994 • 94 citations

Targeted therapy of human immunodeficiency virus‐related disease

1991 • 85 citations

Human immunodeficiency virus protease: A target for aids therapy

1990 • 83 citations

Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease

1996 • 70 citations

HIV protease inhibitors: their anti-HIV activity and potential role in treatment.

1993 • 67 citations

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor

1995 • 55 citations

The pharmacokinetics of combination therapy with nelfinavir plus nevirapine

1998 • 47 citations

Preformulation Studies of a Novel HIV Protease Inhibitor, AG1343

1995 • 41 citations

In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor

1993 • 33 citations

Use of drug combinations for selection of human immunodeficiency virus type I (HIV-1) variants with decreased sensitivity to hydroxyethylurea isostere containing protease inhibitors in vitro

1995 • 3 citations