Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease

Biology of interleukin 1

1988 • 1,547 citations

Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.

1987 • 1,345 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Diabetes Mellitus and Its Degenerative Complications: A Prospective Study of 4,400 Patients Observed Between 1947 and 1973

1978 • 1,311 citations

Structural-functional relationships in diabetic nephropathy.

1984 • 1,202 citations

Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking

1986 • 1,154 citations

Principles and Practice of Ophthalmology

1981 • 1,087 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

EARLY AGGRESSIVE ANTIHYPERTENSIVE TREATMENT REDUCES RATE OF DECLINE IN KIDNEY FUNCTION IN DIABETIC NEPHROPATHY

1983 • 884 citations

Identification of N epsilon-carboxymethyllysine as a degradation product of fructoselysine in glycated protein.

1986 • 830 citations

Long-term antihypertensive treatment inhibiting progression of diabetic nephropathy

1982 • 772 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

Accelerated age-related browning of human collagen in diabetes mellitus.

1984 • 671 citations

Predisposition to Hypertension and Susceptibility to Renal Disease in Insulin-Dependent Diabetes Mellitus

1988 • 650 citations

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

1988 • 606 citations

Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

1986 • 592 citations

Relation between Complications of Type I Diabetes Mellitus and Collagen-Linked Fluorescence

1986 • 579 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Progression of Incipient Diabetic Retinopathy During Good Glycemic Control

1987 • 453 citations

Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta.

1985 • 436 citations

The Biochemistry of the Complications of Diabetes Mellitus

1981 • 430 citations

Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites.

1986 • 374 citations

Aging of proteins: isolation and identification of a fluorescent chromophore from the reaction of polypeptides with glucose.

1984 • 372 citations

Progression of Diabetic Retinopathy after Pancreas Transplantation for Insulin-Dependent Diabetes Mellitus

1988 • 366 citations

Sites of nonenzymatic glycosylation of human hemoglobin A.

1980 • 362 citations

Lipoproteins and atherosclerosis. A look back and a look ahead.

1983 • 315 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

The principal site of nonenzymatic glycosylation of human serum albumin in vivo.

1983 • 311 citations

Effects of age and diabetes mellitus on the solubility and nonenzymatic glucosylation of human skin collagen.

1981 • 310 citations

Banting Lecture 1986: Does a Common Mechanism Induce the Diverse Complications of Diabetes?

1987 • 275 citations

Chemistry of Nonenzymic Browning II

1965 • 267 citations

Kinetic analysis of the nonenzymatic glycosylation of hemoglobin.

1981 • 265 citations

Insulin-Like Growth Factors in Vitreous: Studies in Control and Diabetic Subjects with Neovascularization

1986 • 255 citations

Chemistry of Nonenzymic Browning I. The Reaction between Aldoses and Amines

1963 • 248 citations

High glucose induces DNA damage in cultured human endothelial cells.

1986 • 244 citations

Thrombin stimulates c-sis gene expression in microvascular endothelial cells.

1986 • 235 citations

The kidney in diabetes

1981 • 234 citations

Stimulation of rat mesangial cell proliferation by macrophage interleukin 1.

1983 • 219 citations

Nonenzymatic glucosylation and glucose-dependent cross-linking of protein.

1983 • 218 citations

Modification of DNA by reducing sugars: a possible mechanism for nucleic acid aging and age-related dysfunction in gene expression.

1984 • 211 citations

Studies on Macromolecular Components of Human Glomerular Basement Membrane and Alterations in Diabetes: Decreased Levels of Heparan Sulfate Proteoglycan and Laminin

1987 • 208 citations

Nonenzymatic Glycosylation Products on Collagen Covalently Trap Low-Density Lipoprotein

1985 • 203 citations

Alterations in the Basement Membrane (Heparan Sulfate) Proteoglycan in Diabetic Mice

1982 • 176 citations

Models for the self-assembly of basement membrane.

1986 • 172 citations

The Course of Juvenile Diabetes Treated with Unmeasured Diet

1965 • 169 citations

Unilateral nodular diabetic glomerulosclerosis (Kimmelstiel-Wilson): Report of a case

1973 • 166 citations

Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor.

1986 • 164 citations

Evidence for glucose-mediated covalent cross-linking of collagen after glycosylation in vitro

1985 • 164 citations

Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.

1983 • 157 citations

Increased Vascular Permeability in Spontaneously Diabetic BB/W Rats and in Rats With Mild Versus Severe Streptozocin-Induced Diabetes: Prevention by Aldose Reductase Inhibitors and Castration

1987 • 156 citations

Novel macrophage receptor for glucose-modified proteins is distinct from previously described scavenger receptors.

1986 • 156 citations

Neutral proteinase activity produced in vitro by cells of the glomerular mesangium

1983 • 149 citations

Accumulation of diabetic rat peripheral nerve myelin by macrophages increases with the presence of advanced glycosylation endproducts.

1984 • 139 citations

Micropinocytic ingestion of glycosylated albumin by isolated microvessels: possible role in pathogenesis of diabetic microangiopathy.

1981 • 135 citations

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

1987 • 126 citations

Nonenzymatic Glycosylation Reduces the Susceptibility of Fibrin to Degradation by Plasmin

1983 • 126 citations

Glycation of Skin Collagen in Type I Diabetes Mellitus: Correlation With Long-Term Complications

1986 • 121 citations

[8] Nonenzymatic glucosylation of lysine residues in albumin

1984 • 117 citations

Complications of Diabetes

1983 • 113 citations

Glomerular Basement Membrane Metabolism in the Diabetic Rat: In Vivo Studies

1979 • 112 citations

ε-Amino-Lysine-Bound Glucose in Human Tissues Obtained at Autopsy: Increase in Diabetes Mellitus

1982 • 111 citations

Detection of an advanced glycosylation product bound to protein in situ.

1985 • 106 citations

Genetic Susceptibility to the Development of Retinopathy in Insulin-dependent Diabetics

1982 • 106 citations

Characterization of glycosylated hemoglobins. Relevance to monitoring of diabetic control and analysis of other proteins.

1983 • 101 citations

The release of an immobilized lipoprotein fraction from atherosclerotic lesions by incubation with plasmin

1976 • 101 citations

Immunopathology of Renal Extracellular Membranes in Diabetes Mellitus: Specificity of Tubular Basement-membrane Immunofluorescence

1976 • 100 citations

Diabetic nephropathy: Fault or destiny?

1981 • 93 citations

Studies on macromolecular components of human glomerular basement membrane and alterations in diabetes. Decreased levels of heparan sulfate proteoglycan and laminin

1987 • 88 citations

Modification of DNA by glucose 6-phosphate induces DNA rearrangements in an Escherichia coli plasmid.

1985 • 85 citations

Elevated glucose 6-phosphate levels are associated with plasmid mutations in vivo.

1987 • 84 citations

Glucosylation of human haemoglobin a in red blood cells studied in vitro. Kinetics of the formation and dissociation of haemoglobin A1c

1983 • 78 citations

ROLE OF RISK FACTORS IN COMPLICATIONS OF DIABETES MELLITUS1

1980 • 77 citations

Advanced Diabetic Glomerulopathy: Quantitative Structural Characterization of Nonoccluded Glomeruli

1987 • 77 citations

Recognition and Uptake of Human Diabetic Peripheral Nerve Myelin by Macrophages

1985 • 76 citations

Microvascular permeability to plasma proteins in hypertension and diabetes mellitus in man--on the pathogenesis of hypertensive and diabetic microangiopathy.

1975 • 69 citations

Specific Macrophage Receptor Activity for Advanced Glycosylation End Products Inversely Correlates With Insulin Levels In Vivo

1988 • 68 citations

Nonenzymatic Glycation of Fibronectin and Alterations in the Molecular Association of Cell Matrix and Basement Membrane Components in Diabetes Mellitus

1985 • 67 citations

Reduced Susceptibility of Nonenzymatically Glucosylated Glomerular Basement Membrane to Proteases

1980 • 56 citations

Glomerular Proteoglycans in Diabetes: Partial Structural Characterization and Metabolism of De Novo Synthesized Heparan-35SO4 and Dermatan-35SO4 Proteoglycans in Streptozocin-Induced Diabetic Rats

1986 • 51 citations

Glomerular basement membrane metabolism in the diabetic rat. In vivo studies

1979 • 46 citations

The formation of reactive intermediate(s) of glucose 6-phosphate and lysine capable of rapidly reacting with DNA

1987 • 45 citations

epsilon-Amino-lysine-bound glucose in human tissues obtained at autopsy. Increase in diabetes mellitus

1982 • 45 citations

Increased Concentration of Albumin in Kidney Basement Membranes in Diabetes Mellitus

1981 • 41 citations

Increased single strand breaks in DNA of lymphocytes from diabetic subjects.

1987 • 38 citations

Diabetic macroangiopathy. Quantitative histopathological studies of the extramural coronary arteries from type 2 (non-insulin-dependent) diabetic patients.

1987 • 36 citations

Diabetic Nephropathy: A Perspective

1983 • 35 citations

Endocrine Pathology: General and Surgical

1982 • 35 citations

Nonenzymatic Glycosylation and Browning of Proteins In Vivo

1983 • 34 citations

Alterations in the rat renal glycosaminoglycans in streptozotocin-induced diabetes

1983 • 31 citations

Immunofluorescence studies of skeletal muscle extracellular membranes in diabetes mellitus.

1978 • 30 citations

Advanced diabetic glomerulopathy. Quantitative structural characterization of nonoccluded glomeruli

1987 • 30 citations

Diabetic Nephropathy and Proliferative Retinopathy with Normal Glucose Tolerance

1985 • 29 citations

Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo

1988 • 29 citations

Recognition and uptake of human diabetic peripheral nerve myelin by macrophages

1985 • 27 citations

In vivo influx of free and esterified plasma cholesterol into human aortic tissue without atherosclerotic lesions.

1984 • 27 citations

Non-enzymatic glycosylation of tissue protein in diabetes in the rat

1983 • 27 citations

Diabetic macroangiopathy

1987 • 27 citations

Aldehydes or dicarbonyls in non-enzymic glycosylation of proteins

1985 • 23 citations

Pathogenetic heterogeneity in retinal capillary basement membrane thickening in the diabetic BB-rat

1987 • 19 citations

International Review of Experimental Pathology

1985 • 16 citations

Glomerular proteoglycans in diabetes. Partial structural characterization and metabolism of de novo synthesized heparan-35SO4 and dermatan-35SO4 proteoglycans in streptozocin-induced diabetic rats

1986 • 15 citations

Increased concentration of albumin in kidney basement membranes in diabetes mellitus

1981 • 14 citations

Diabetic retinopathy: Clinical evaluation and management

1981 • 13 citations

Human Glomerular Basement Membrane: Altered Binding Characteristics following in Vitro Non-enzymatic Glycosylation

1986 • 10 citations

Pathogenesis of Atherosclerosis

2011 • 3 citations

Deleted Work

1955 • 0 citations