Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Introduction to Statistical Analysis.

1957 • 5,236 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

1993 • 1,455 citations

A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX

1990 • 923 citations

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1991 • 337 citations

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

1997 • 320 citations

An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype

1996 • 278 citations

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit.

1994 • 255 citations

Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.

1992 • 242 citations

Nicotine-induced protection of cultured cortical neurons againstN-methyl-D-aspartate receptor-mediated glutamate cytotoxicity

1994 • 240 citations

Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation

1996 • 225 citations

A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans

1995 • 203 citations

Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocinnamylidine derivative is a selective agonist at neuronal nicotinic alpha 7/125I-alpha-bungarotoxin receptor subtypes.

1995 • 192 citations

Synaptic Currents Generated by Neuronal Acetylcholine Receptors Sensitive to α-Bungarotoxin

1996 • 189 citations

Flow cytometric measurement of cytoplasmic free calcium in human peripheral blood T lymphocytes with fluo-3, a new fluorescent calcium indicator

1990 • 184 citations

Nicotine inhibition of apoptosis suggests a role in tumor promotion

1993 • 177 citations

3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat α7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

1997 • 159 citations

Nicotinic α7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage

1998 • 142 citations

Specific inhibition of cytoplasmic protein tyrosine kinases by herbimycin A in vitro

1991 • 139 citations

Relationship between Apoptosis and the Cell Cycle in Lymphocytes: Roles of Protein Kinase C, Tyrosine Phosphorylation, and AP1

1993 • 111 citations

Effects of anabaseine‐related analogs on rat brain nicotinic receptor binding and on avoidance behaviors

1994 • 101 citations

Inhibition of Tyrosine Phosphorylation Prevents Delayed Neuronal Death following Cerebral Ischemia

1993 • 88 citations

Neuroprotective and memory-related actions of novel alpha-7 nicotinic agents with different mixed agonist/antagonist properties.

1998 • 85 citations

Detection of Functional Nicotinic Receptors Blocked by α-Bungarotoxin on PC12 Cells and Dependence of Their Expression on Post-Translational Events

1997 • 83 citations

Cytoprotective actions of 2,4‐dimethoxybenzylidene anabaseine in differentiated PC12 cells and septal cholinergic neurons

1994 • 78 citations

Nitric oxide stimulates stress‐activated protein kinases in glomerular endothelial and mesangial cells

1996 • 62 citations

Activation and inhibition of rat neuronal nicotinic receptors by ABT‐418

1997 • 56 citations

Target cell-induced apoptosis of interleukin-2-activated human natural killer cells: roles of cell surface molecules and intracellular events

1996 • 56 citations

Induction of Hydrogen Peroxide Production and Bax Expression by Caspase-3(-Like) Proteases in Tyrosine Kinase Inhibitor-Induced Apoptosis in Human Small Cell Lung Carcinoma Cells

1998 • 44 citations

Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9

1996 • 43 citations

Phosphotyrosine inhibition and control of vascular endothelial cell proliferation by genistein

1994 • 37 citations

The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.

1997 • 37 citations

Oxygen-Dependent Fragmentation of Cellular DNA by Nitric Oxide

1997 • 29 citations

Effects of peroxidation and aging on rat neocortical ACh-release and protein kinase C

1994 • 20 citations

Stimulation of 1-(beta-D-arabinofuranosyl)cytosine (AraC)-induced apoptosis in the multidrug resistant human promyelocytic leukemia cell lines with protein kinase inhibitors.

1996 • 14 citations

Development of cellular resistance to pp60v-src kinase-induced cell death.

1995 • 4 citations