Insulin binding changes the interface region between .alpha. subunits of the insulin receptor

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Insulin Receptor: Evidence That It Is a Protein Kinase

1983 • 413 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes.

1980 • 388 citations

Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries.

1980 • 312 citations

Purification of insulin receptor with full binding activity.

1983 • 273 citations

Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.

1982 • 254 citations

Insulin receptor: covalent labeling and identification of subunits.

1979 • 243 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

The .beta. subunit of the insulin receptor kinase is an insulin-activated protein

1983 • 219 citations

Photoaffinity labeling of insulin receptor of rat adiopocyte plasma membrane.

1978 • 216 citations

Receptor-mediated phosphorylation of the hepatic insulin receptor: Evidence that the M _r 95,000 receptor subunit is its own kinase

1983 • 213 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

[5] Direct identification of specific glycoproteins and antigens in sodium dodecyl sulfate gels

1978 • 206 citations

Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta.

1984 • 201 citations

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody.

1980 • 187 citations

Identification of insulin receptor tyrosine residues autophosphorylated in vitro.

1987 • 182 citations

A unique proteolytic cleavage site on the beta subunit of the insulin receptor.

1981 • 167 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

Purification and properties of the human placental insulin receptor.

1981 • 161 citations

Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system.

1988 • 120 citations

Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells.

1987 • 120 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

Structural requirements for the transmembrane activation of the insulin receptor kinase.

1986 • 93 citations

Ligand-dependent intersubunit association within the insulin receptor complex activates its intrinsic kinase activity.

1988 • 70 citations

Hormone Binding Alters the Conformation of the Insulin Receptor

1980 • 70 citations

Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes.

1987 • 57 citations

Purification of the insulin receptor from human placental membranes

1979 • 46 citations

Hormone-induced conformational changes in the hepatic insulin receptor.

1983 • 46 citations

Insulin receptor: insulin-modulated interconversion between distinct molecular forms involving disulfide sulfhydryl exchange

1983 • 43 citations

An Mr 180000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta

1987 • 28 citations

Urea treatment allows dithiothreitol to release the binding subunit of the insulin receptor from the cell membrane: Implications for the structural organization of the insulin receptor

1985 • 26 citations

Separation and characterization of three insulin receptor species that differ in subunit composition

1988 • 22 citations