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A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine–acetylcholine synaptic balance

Data up to Jan 2025

Published2006
Citations334
References105

Total Citations Per Year

Abstract

References (105)

Dopamine, learning and motivation

2004 • 3,146 citations

The Role of the Medial Frontal Cortex in Cognitive Control

2004 • 2,883 citations

Frontal-Subcortical Circuits and Human Behavior

1993 • 2,248 citations

Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning

2004 • 2,078 citations

By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism

2004 • 1,951 citations

The Architecture of Cognitive Control in the Human Prefrontal Cortex

2003 • 1,802 citations

An Essay on the Shaking Palsy

2002 • 1,658 citations

Neurotransmitters and neuromodulators in the basal ganglia

1990 • 1,578 citations

Striatal interneurones: chemical, physiological and morphological characterization

1995 • 1,174 citations

Rivastigmine for Dementia Associated with Parkinson's Disease

2004 • 1,153 citations

An Area Specialized for Spatial Working Memory in Human Frontal Cortex

1998 • 957 citations

Building Neural Representations of Habits

1999 • 842 citations

Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia

2003 • 801 citations

Acetylcholine in mind: a neurotransmitter correlate of consciousness?

1999 • 750 citations

Long-Term Potentiation of Excitatory Inputs to Brain Reward Areas by Nicotine

2000 • 715 citations

Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease

1983 • 712 citations

Dementia associated with Parkinson's disease

2003 • 680 citations

Long-term synaptic depression in the striatum: physiological and pharmacological characterization

1992 • 667 citations

Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum

2001 • 574 citations

Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.

1985 • 570 citations

Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty

2003 • 553 citations

Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

1987 • 532 citations

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

2002 • 531 citations

Dopaminergic Control of Corticostriatal Long-Term Synaptic Depression in Medium Spiny Neurons Is Mediated by Cholinergic Interneurons

2006 • 498 citations

Phenotypical characterization of the rat striatal neurons expressing the D1 dopamine receptor gene.

1991 • 477 citations

Cognitive function in Parkinson's disease: From description to theory

1990 • 473 citations

The corticostriatal projection: from synaptic plasticity to dysfunctions of the basal ganglia

1996 • 459 citations

Acetylcholine-mediated modulation of striatal function

2000 • 436 citations

Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition

2003 • 410 citations

Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation

2000 • 402 citations

Identification of the Nicotinic Receptor Subtypes Expressed on Dopaminergic Terminals in the Rat Striatum

2002 • 400 citations

Mechanisms of cognitive set flexibility in Parkinson's disease

2001 • 399 citations

Choline transporters, cholinergic transmission and cognition

2004 • 379 citations

Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals

2004 • 367 citations

Lesions of the Basal Forebrain Cholinergic System Impair Task Acquisition and Abolish Cortical Plasticity Associated with Motor Skill Learning

2003 • 355 citations

Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study

2002 • 345 citations

Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity.

2000 • 345 citations

Neural Bases of Set-Shifting Deficits in Parkinson's Disease

2004 • 340 citations

Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?

2004 • 340 citations

Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity

2000 • 323 citations

Cholinergic dysfunction in diseases with Lewy bodies

2000 • 318 citations

Selective D2 Receptor Actions on the Functional Circuitry of Working Memory

2004 • 316 citations

Anatomy of the dopamine system in the basal ganglia

2000 • 316 citations

Smoking, nicotine and Parkinson's disease

2004 • 309 citations

Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

1989 • 291 citations

Visuospatial impairment in Parkinson's disease

1991 • 283 citations

DIFFERENT EFFECTS OF DOPAMINERGIC AND ANTICHOLINERGIC THERAPIES ON COGNITIVE AND MOTOR FUNCTION IN PARKINSON'S DISEASE

1992 • 282 citations

Fluctuations in attention

2002 • 275 citations

Relationship of motor symptoms to intellectual deficits in Parkinson disease

1982 • 270 citations

D2Dopamine Receptors Reduce N-Type Ca2+Currents in Rat Neostriatal Cholinergic Interneurons Through a Membrane-Delimited, Protein-Kinase-C-Insensitive Pathway

1997 • 258 citations

Parkinson's disease: Neuron loss in the nucleus basalis without concomitant Alzheimer's disease

1984 • 254 citations

RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion

2006 • 241 citations

Presynaptic nicotinic receptors modulating dopamine release in the rat striatum

2000 • 234 citations

Dopamine Modulates Release from Corticostriatal Terminals

2004 • 229 citations

Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors

2004 • 224 citations

Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia

2003 • 216 citations

D2Dopamine Receptor-Mediated Modulation of Voltage-Dependent Na+Channels Reduces Autonomous Activity in Striatal Cholinergic Interneurons

2004 • 210 citations

M2Muscarinic Acetylcholine Receptor Knock-Out Mice Show Deficits in Behavioral Flexibility, Working Memory, and Hippocampal Plasticity

2004 • 206 citations

The activation of 5‐HT2A receptors in prefrontal cortex enhances dopaminergic activity

2005 • 203 citations

Unilateral Dopamine Denervation Blocks Corticostriatal LTP

1999 • 203 citations

Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat

1988 • 201 citations

Local Infusion of Scopolamine Into Intraparietal Cortex Slows Covert Orienting in Rhesus Monkeys

2000 • 194 citations

D2 dopamine receptor gene expression by cholinergic neurons in the rat striatum

1990 • 191 citations

A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease

1991 • 191 citations

Norepinephrine in the Prefrontal Cortex Is Critical for Amphetamine-Induced Reward and Mesoaccumbens Dopamine Release

2003 • 186 citations

Cholinergic‐dependent cognitive deficits in Parkinson's disease

1987 • 177 citations

A subcortico-cortical cholinergic system is affected in Parkinson's disease

1983 • 176 citations

Activation of D2-Like Dopamine Receptors Reduces Synaptic Inputs to Striatal Cholinergic Interneurons

2000 • 165 citations

Nicotinic Acetylcholine Receptor Distribution in Alzheimer's Disease, Dementia with Lewy Bodies, Parkinson's Disease, and Vascular Dementia: In Vitro Binding Study Using 5-[125I]-A-85380

2003 • 165 citations

Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function

2000 • 159 citations

Chronic effects of dopaminergic replacement on cognitive function in Parkinson's disease: A two-year follow-up study of previously untreated patients

2000 • 157 citations

Muscarine depolarizes rat substantia nigra zona compacta and ventral tegmental neurons in vitro through M1-like receptors.

1990 • 156 citations

D1 and D2 Dopaminergic Regulation of Acetylcholine Release from Striata of Freely Moving Rats

1990 • 152 citations

Dopamine-Dependent Synaptic Plasticity in the Striatal Cholinergic Interneurons

2001 • 150 citations

Dopamine receptors: from structure to behavior

2000 • 149 citations

Dopamine D1-like receptor activation excites rat striatal large aspiny neurons in vitro.

1998 • 147 citations

Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists

2000 • 139 citations

Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP

1999 • 129 citations

Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression

2002 • 127 citations

Dopamine D1-Like Receptor Activation Excites Rat Striatal Large Aspiny NeuronsIn Vitro

1998 • 126 citations

Cholinergic deficiency and frontal dysfunction in Parkinson's disease

1990 • 125 citations

Altered Muscarinic and Nicotinic Receptor Densities in Cortical and Subcortical Brain Regions in Parkinson's Disease

1993 • 120 citations

Disturbed frontal regulation of attention in Parkinson's disease

1993 • 115 citations

Blockade of M2‐like muscarinic receptors enhances long‐term potentiation at corticostriatal synapses

1998 • 101 citations

Levodopa improves motor function without impairing cognition in mild non-demented Parkinson's disease patients

1998 • 99 citations

Medial Prefrontal and Subcortical Mechanisms Underlying the Acquisition of Motor and Cognitive Action Sequences in Humans

2002 • 93 citations

Consequences of failures to meet standards in learning and memory

2004 • 93 citations

Cellular Expression of α7 Nicotinic Acetylcholine Receptor Protein in the Temporal Cortex in Alzheimer's and Parkinson's Disease— A Stereological Approach

2000 • 92 citations

Plastic and behavioral abnormalities in experimental Huntington's disease: A crucial role for cholinergic interneurons

2005 • 89 citations

Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism

2004 • 83 citations

A post-mortem study on striatal dopamine receptors in Parkinson's disease

1991 • 79 citations

Acute and Long-Term Administration of Anticholinergics in Parkinson's Disease: Specific Effects on the Subcortico-Frontal Syndrome

1999 • 74 citations

Differential effects of M1 muscarinic receptor blockade and nicotinic receptor blockade in the dorsomedial striatum on response reversal learning

2004 • 73 citations

Chronic Oral Nicotine Normalizes Dopaminergic Function and Synaptic Plasticity in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Primates

2006 • 72 citations

Neuroprotection and pharmacotherapy for motor symptoms in Parkinson's disease

2004 • 71 citations

Excitatory effects of serotonin on rat striatal cholinergic interneurones

2005 • 68 citations

Combined Nicotinic and Muscarinic Blockade in Elderly Normal Volunteers: Cognitive, Behavioral, and Physiologic Responses

1998 • 65 citations

DOPAMINE ACETYLCHOLINE IMBALANCE IN PARKINSON'S DISEASE

1976 • 64 citations

Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson’s disease

2002 • 64 citations

Dysfunction of the human memory systems

2003 • 58 citations

Pergolide effect on cognitive functions in early-mild Parkinson?s disease

2004 • 42 citations

Reduced D2 dopamine and muscarinic cholinergic receptor densities in caudate specimens from fluctuating parkinsonian patients

1991 • 36 citations

Impaired cognitive shifting in parkinsonian patients on anticholinergic therapy

1993 • 29 citations

Local application of SCH 39166 reversibly and dose-dependently decreases acetylcholine release in the rat striatum

1999 • 13 citations

Cholinergic markers in degenerative parkinsonism: autoradiographic demonstration of high-affinity choline uptake carrier hyperactivity

1994 • 13 citations

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