Plastic and behavioral abnormalities in experimental Huntington's disease: A crucial role for cholinergic interneurons

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Inactivation of Hippocampus or Caudate Nucleus with Lidocaine Differentially Affects Expression of Place and Response Learning

1996 • 1,470 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

1999 • 933 citations

Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia

2003 • 801 citations

Huntingtin–protein interactions and the pathogenesis of Huntington's disease

2004 • 526 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

1995 • 471 citations

Acetylcholine-mediated modulation of striatal function

2000 • 436 citations

Replicating Huntington's disease phenotype in experimental animals

1999 • 410 citations

Long‐term Potentiation in the Striatum is Unmasked by Removing the Voltage‐dependent Magnesium Block of NMDA Receptor Channels

1992 • 408 citations

Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation

2000 • 406 citations

Selective Discrimination Learning Impairments in Mice Expressing the Human Huntington's Disease Mutation

1999 • 383 citations

Evidence for specific cognitive deficits in preclinical Huntington's disease

1998 • 382 citations

Executive and mnemonic functions in early Huntington's disease

1996 • 379 citations

Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity.

2000 • 345 citations

Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity

2000 • 323 citations

Morphologic and Histochemical Characteristics of a Spared Subset of Striatal Neurons in Huntington's Disease

1987 • 296 citations

Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases.

1994 • 281 citations

Partial Inhibition of Brain Succinate Dehydrogenase by 3‐Nitropropionic Acid Is Sufficient to Initiate Striatal Degeneration in Rat

1998 • 206 citations

Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect

2004 • 185 citations

Involvement of the dorsomedial striatum in behavioral flexibility: role of muscarinic cholinergic receptors

2002 • 171 citations

Quantifiable bradykinesia, gait abnormalities and Huntington's disease-like striatal lesions in rats chronically treated with 3-nitropropionic acid

1997 • 154 citations

Central cholinergic‐anticholinergic antagonism in Huntington's chorea

1972 • 150 citations

Dopamine-Dependent Synaptic Plasticity in the Striatal Cholinergic Interneurons

2001 • 150 citations

Striatal spiny neurons and cholinergic interneurons express differential ionotropic glutamatergic responses and vulnerability: Implications for ischemia and Huntington's disease

1998 • 132 citations

Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP

1999 • 129 citations

Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies

2000 • 109 citations

Progress in Understanding the Factors Regulating Reversibility of Long-term Potentiation

2001 • 102 citations

Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1

2004 • 98 citations

Vesicular neurotransmitter transporters in Huntington's disease: Initial observations and comparison with traditional synaptic markers

2001 • 86 citations

Corticostriatopallidal Neuroprotection by Adenovirus-Mediated Ciliary Neurotrophic Factor Gene Transfer in a Rat Model of Progressive Striatal Degeneration

2002 • 83 citations

Post‐ischaemic long‐term synaptic potentiation in the striatum: a putative mechanism for cell type‐specific vulnerability

2002 • 68 citations

Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington’s disease

2004 • 65 citations

Huntington's Disease: Regional alteration in muscarinic cholinergic receptor binding in human brain

1976 • 65 citations

Decreased muscarinic receptor concentration in post-mortem brain in Huntington's chorea

1974 • 58 citations

Mice transgenic for exon 1 of Huntington's disease: properties of cholinergic and dopaminergic pre‐synaptic function in the striatum

2003 • 53 citations

Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat

2001 • 50 citations

Cerebrospinal fluid choline in extrapyramidal disorders

1972 • 42 citations

Perseverative Behavior Underlying Attentional Set-Shifting Deficits in Rats Chronically Treated with the Neurotoxin 3-Nitropropionic Acid

2001 • 41 citations

Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons

2004 • 26 citations

Enhanced procedural learning following beta-amyloid protein (1-42) infusion in the rat

2002 • 18 citations