Differences in G-protein activation by μ- and δ-opioid, and cannabinoid, receptors in rat striatum

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

1990 • 4,933 citations

Determination and characterization of a cannabinoid receptor in rat brain.

1988 • 2,339 citations

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

1991 • 2,139 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

1992 • 694 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality

1982 • 466 citations

Opioid receptor-coupled second messenger systems

1991 • 466 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.

1995 • 450 citations

Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.

1986 • 446 citations

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1995 • 441 citations

Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.

1985 • 248 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Differential Regulation by Guanine Nucleotides of Opiate Agonist and Antagonist Receptor Interactions

1980 • 201 citations

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

1990 • 173 citations

Muscarinic acetylcholine receptor‐stimulated binding of guanosine 5′‐O‐(3‐thiotriphosphate) to guanine‐nucleotide‐binding proteins in cardiac membranes

1989 • 170 citations

Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.

1986 • 169 citations

?2-Adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium

1987 • 163 citations

Aminoalkylindole binding in rat cerebellum: selective displacement by natural and synthetic cannabinoids.

1993 • 157 citations

Accelerated communciation: Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence

1994 • 154 citations

Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein.

1990 • 146 citations

Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles

1992 • 140 citations

Aminoalkylindoles: actions on specific G-protein-linked receptors.

1991 • 124 citations

Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.

1990 • 124 citations

Dynorphin A and cAMP-dependent protein kinase independently regulate neuronal calcium currents.

1990 • 104 citations

Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors.

1993 • 101 citations

Signal amplification in HL‐60 granulocytes

1991 • 88 citations

Multiple agonist-affinity states of opioid receptors: regulation of binding by guanyl nucleotides in guinea pig cortical, NG108-15, and 7315c cell membranes.

1988 • 78 citations

Distinct guanine nucleotide binding and release properties of the three Gi proteins.

1990 • 75 citations

Novel localization of a G protein, Gz-alpha, in neurons of brain and retina

1990 • 74 citations

Role of cyclic amp dependent protein kinase in cannabinoid receptor modulation of potassium “A-current” in cultured rat hippocampal neurons

1995 • 70 citations

Mechanisms of opioid actions on neurons of the locus coeruleus

1991 • 52 citations

The subcellular localization of the G-protein Gi alpha in the basal ganglia reveals its potential role in both signal transduction and vesicle trafficking

1992 • 50 citations

The opioid receptors in the hamster vas deferens are of the δ-type

1985 • 49 citations

Immunohistochemical distribution of neurons containing the G-proteins Gqα/G11α in the adult rat brain

1992 • 35 citations

Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.

1992 • 28 citations

Immunochemical and Immunohistochemical Localization of the G Protein G11 in Rat Central Nervous Tissues1

1990 • 25 citations

What are the functions of the pertussis toxin-insensitive G proteins G 12 , G 13 and G z ?

1994 • 19 citations

Studies on the intrinsic activity (efficacy) of human adrenergic receptors. Co-expression of beta 1 and beta 2 reveals a lower efficacy for the beta 1 receptor.

1994 • 7 citations

New fears at Hanford

1990 • 1 citations