Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

1975 • 1,358 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

An established pre-adipose cell line and its differentiation in culture

1974 • 1,090 citations

Sublines of mouse 3T3 cells that accumulate lipid

1974 • 918 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.

1978 • 732 citations

Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells.

1978 • 678 citations

Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots

1984 • 668 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs.

1986 • 411 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

1984 • 411 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.

1984 • 265 citations

The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.

1986 • 253 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit.

1983 • 237 citations

Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

1986 • 233 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.

1977 • 175 citations

Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni.

1985 • 160 citations

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

1986 • 158 citations

Primary structure of the β‐subunit of bovine transducin deduced from the cDNA sequence

1985 • 155 citations

β‐Subunits of the human liver G_s/G_i signal‐transducing proteins and those of bovine retinal rod cell transducin are identical

1986 • 119 citations

Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.

1985 • 114 citations

Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.

1985 • 98 citations

Dexamethasone regulates the beta-adrenergic receptor subtype expressed by 3T3 L1 preadipocytes and adipocytes.

1982 • 92 citations

Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase.

1981 • 86 citations

Differentiation-dependent expression of catecholamine-stimulated adenylate cyclase. Roles of the beta-receptor and G/F protein in differentiating 3T3-L1 adipocytes.

1981 • 82 citations

Purification of a beta 35 form of the beta gamma complex common to G-proteins from human placental membranes.

1987 • 81 citations

Hormone-sensitive particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes. Regulation of responsiveness by dexamethasone.

1983 • 71 citations

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.

1986 • 70 citations

The presence of free G protein beta/gamma subunits in human neutrophils results in suppression of adenylate cyclase activity.

1987 • 66 citations

G-proteins of fat-cells Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate

1986 • 62 citations

Changes in the guanine nucleotide‐binding proteins, G_i and g_o, during differentiation of 3T3‐L1 cells

1986 • 51 citations

Heart contains two substrates (Mr = 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns

1985 • 50 citations

Pertussis toxin catalyzes the ADP‐ribosylation of two distinct peptides, 40 and 41 kDa, in rat fat cell membranes

1984 • 48 citations

ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats

1979 • 48 citations

Fat cell beta-adrenergic receptor in the hypothyroid rat. Impaired interaction with the stimulatory regulatory component of adenylate cyclase.

1984 • 42 citations

Characterization of Adrenocorticotropin Receptors that Appear when 3T3-L1 Cells Differentiate into Adipocytes*

1985 • 38 citations

Effect of differentiation on the adenylate cyclase system of 3T3-C2 and 3T3-L1 cells. Determination of choleragen substrates in differentiating 3T3-L1 and nondifferentiating 3T3-C2 cells.

1982 • 24 citations