Apoptosis: function and regulation of cell death

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

The Fas Death Factor

1995 • 4,070 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

The Atlas of Mouse Development

1992 • 1,782 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

The atlas of mouse development

1993 • 1,427 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

A role for CD95 ligand in preventing graft rejection

1995 • 1,184 citations

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

1995 • 1,179 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

1994 • 843 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Induction of cell death by endogenous nerve growth factor through its p75 receptor

1996 • 750 citations

Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B

1995 • 720 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1995 • 616 citations

Fas and FasL in the homeostatic regulation of immune responses

1995 • 579 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Tumor necrosis factor.

1991 • 568 citations

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1992 • 542 citations

Induction of a Common Pathway of Apoptosis by Staurosporine

1994 • 491 citations

CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis

1996 • 480 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.

1992 • 447 citations

Calpain activation in apoptosis

1994 • 445 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

1994 • 396 citations

Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells

1996 • 394 citations

Cell Killing by the Drosophila Gene reaper

1996 • 375 citations

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1996 • 370 citations

Perforin: structure and function

1995 • 361 citations

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

1996 • 316 citations

Tumor necrosis factor receptor superfamily members and their ligands

1994 • 313 citations

Signalling mechanisms and oxidative stress in apoptosis

1995 • 306 citations

Programmed cell death in Dictyostelium

1994 • 284 citations

The genetic regulation of apoptosis

1995 • 283 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

1995 • 243 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia.

1984 • 227 citations

Kinetics of plasma membrane and mitochondrial alterations in cells undergoing apoptosis

1995 • 219 citations

Regulation of cell surface APO‐1/Fas (CD95) ligand expression by metalloproteases

1995 • 216 citations

A novel function of CD40: induction of cell death in transformed cells.

1996 • 202 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Single‐step procedure for labeling DNA strand breaks with fluorescein‐ or Bodipy‐conjugated deoxynucleotides: Detection of apoptosis and bromodeoxyuridine incorporation

1995 • 178 citations

Identification, characterization, and purification of a tobacco endonuclease activity induced upon hypersensitive response cell death.

1995 • 177 citations

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.

1995 • 175 citations

An essential role for gp39, the ligand for CD40, in thymic selection.

1995 • 148 citations

Role of multiple cellular proteases in the execution of programmed cell death

1995 • 141 citations

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

1996 • 134 citations

Quantification of Apoptosis and Necrosis by Flow Cytometry

1993 • 96 citations

Tumor necrosis factor (cachectin) in the biology of septic shock syndrome.

1991 • 94 citations

Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.

1994 • 81 citations

CD95 (APO-1/Fas)-associating signalling proteins.

1996 • 76 citations

Regulation of apoptosis in immune cells

1995 • 72 citations

Virus proteins that bind cytokines, chemokines or interferons

1996 • 71 citations

Bcl-2 Overexpression Blocks Activation of the Death Protease CPP32/Yama/Apopain

1996 • 64 citations

Apoptosis (programmed cell death) and other reasons for elimination of neurons and axons

1995 • 54 citations

A simplified method for the coordinate examination of apoptosis and surface phenotype of murine lymphocytes

1995 • 42 citations

Fas-Based T Cell-Mediated Cytotoxicity

1995 • 20 citations

Exponential growth in apoptosis

1995 • 16 citations

Deleted Work

1955 • 0 citations