Paclitaxel sensitivity correlates with P53 status and DNA fragmentation, but not G2/M accumulation

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Cancer: Principles and Practice of Oncology

1997 • 1,408 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Bcl2 is the guardian of microtubule integrity.

1997 • 599 citations

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.

1993 • 526 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Taxol: A novel radiation sensitizer

1992 • 319 citations

Relationship of Mitotic Arrest and Apoptosis to Antitumor Effect of Paclitaxel

1996 • 290 citations

Cell cycle checkpoints

1994 • 284 citations

In Vitro Studies of Taxol as a Radiation Sensitizer in Human Tumor Cells

1994 • 268 citations

Taxol sensitizes human astrocytoma cells to radiation.

1992 • 267 citations

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1996 • 217 citations

Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telephase.

1994 • 200 citations

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

1997 • 198 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

p53-independent apoptosis induced by paclitaxel through an indirect mechanism

1997 • 173 citations

p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel.

1997 • 148 citations

Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.

1995 • 120 citations

Radiation inactivation of human prostate cancer cells: the role of apoptosis.

1996 • 83 citations

Taxol and radiation.

1993 • 65 citations

Radiation and taxol effects on synchronized human cervical carcinoma cells

1994 • 64 citations

Paclitaxel in Cancer Treatment

1996 • 62 citations

Radiation Inactivation of Human Prostate Cancer Cells: The Role of Apoptosis

1996 • 56 citations

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1995 • 48 citations

Paclitaxel in cancer treatment

1995 • 47 citations