Phosphorylation of Bcl-2 Is a Marker of M Phase Events and Not a Determinant of Apoptosis

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Taxol: A Novel Investigational Antimicrotubule Agent

1990 • 1,084 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

1996 • 777 citations

Mitosis in transition

1994 • 745 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Bcl2 is the guardian of microtubule integrity.

1997 • 599 citations

Taxol: an antimitotic agent with a new mechanism of action

1984 • 483 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death.

1997 • 387 citations

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway.

1996 • 376 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis.

1994 • 222 citations

Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells.

1996 • 206 citations

Taxol induction of p21WAF1 and p53 requires c-raf-1.

1995 • 187 citations

Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells.

1993 • 177 citations

Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells.

1992 • 169 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Bcl-xL overexpression inhibits progression of molecular events leading to paclitaxel-induced apoptosis of human acute myeloid leukemia HL-60 cells.

1997 • 114 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

Accumulation of cyclin B1, activation of cyclin B1-dependent kinase and induction of programmed cell death in human epidermoid carcinoma KB cells treated with taxol

1998 • 93 citations

Bcl-2 protein localizes to the chromosomes of mitotic nuclei and is correlated with the cell cycle in cultured epithelial cell lines

1994 • 78 citations

Activation of T Cell Raf-1 at Mitosis Requires the Protein-tyrosine Kinase Lck

1996 • 25 citations