Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer.

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

1993 • 1,646 citations

Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.

1997 • 1,590 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

Regulators of Angiogenesis

1991 • 959 citations

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors.

1997 • 841 citations

Phase Ib Trial of Intravenous Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor in Combination With Chemotherapy in Patients With Advanced Cancer: Pharmacologic and Long-Term Safety Data

2001 • 369 citations

The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.

2001 • 333 citations

Comparison of microscopic vascularity in benign and malignant prostate tissue

1993 • 327 citations

Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer.

2001 • 299 citations

Vascular Endothelial Growth Factor (VEGF) Expression in Human Prostate Cancer: In Situ and in Vitro Expression of VEGF by Human Prostate Cancer Cells

1997 • 286 citations

Prostate Cancer Cell Cycle Regulators: Response to Androgen Withdrawal and Development of Androgen Independence

1999 • 249 citations

Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo

1998 • 248 citations

CWR22: the first human prostate cancer xenograft with strongly androgen-dependent and relapsed strains both in vivo and in soft agar.

1996 • 241 citations

Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis

2001 • 240 citations

Testosterone Stimulates Angiogenesis and Vascular Regrowth in the Ventral Prostate in Castrated Adult Rats¹

1998 • 239 citations

Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma.

2000 • 228 citations

Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue.

1997 • 215 citations

A tyrosine kinase profile of prostate carcinoma.

1996 • 212 citations

Expression of vascular endothelial growth factor receptors in human prostate cancer

1999 • 202 citations

Vascular Endothelial Growth Factor (VEGF) Expression in Prostate Cancer and Benign Prostatic Hyperplasia

1997 • 185 citations

VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION AND TUMOR ANGIOGENESIS ARE REGULATED BY ANDROGENS IN HORMONE RESPONSIVE HUMAN PROSTATE CARCINOMA: : EVIDENCE FOR ANDROGEN DEPENDENT DESTABILIZATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR TRANSCRIPTS

2001 • 163 citations

Xenografts of Primary Human Prostatic Carcinoma

1993 • 152 citations

Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas.

1998 • 145 citations

Response of prostate cancer to anti-Her-2/neu antibody in androgen-dependent and -independent human xenograft models.

1999 • 144 citations

Association between immunohistochemical expression of vascular endothelial growth factor (VEGF), VEGF-expressing neuroendocrine-differentiated tumor cells, and outcome in prostate cancer patients subjected to watchful waiting.

2000 • 138 citations

Vascular Endothelial Growth Factor-Mediated Autocrine Stimulation of Prostate Tumor Cells Coincides with Progression to a Malignant Phenotype

2001 • 108 citations

Vascular Endothelial Growth Factor Is Up-Regulatedin Vitroandin Vivoby Androgens

1998 • 105 citations

Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers.

1997 • 102 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor Flk-1 in Benign, Premalignant, and Malignant Prostate Tissue

2001 • 77 citations

Tumor vascularity and basement membrane structure as prognostic factors in T1-2MO prostatic adenocarcinoma.

1994 • 65 citations

Elevated serum vascular endothelial growth factor in patients with hormone‐escaped prostate cancer

2000 • 56 citations

EXPRESSION OF THE VEGF-RECEPTOR Flt-1 IN BENIGN, PREMALIGNANT AND MALIGNANT PROSTATE TISSUES

2000 • 55 citations

A potential role for activated HER-2 in prostate cancer.

2000 • 41 citations

CWR22 Xenograft as an Ex Vivo Human Tumor Model for Prostate Cancer Gene Therapy

1996 • 31 citations

Vascular Endothelial Growth Factor

2000 • 29 citations

Modulation of human microvascular endothelial cell bioenergetic status and glutathione levels during proliferative and differentiated growth

1993 • 28 citations

True

2000 • 18 citations