CWR22 Xenograft as an Ex Vivo Human Tumor Model for Prostate Cancer Gene Therapy

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Cancer statistics, 1995

1995 • 1,434 citations

Prostate Specific Antigen: A Critical Assessment of the Most Useful Tumor Marker for Adenocarcinoma of the Prostate

1991 • 1,273 citations

Human gene therapy comes of age

1992 • 927 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.

1990 • 628 citations

In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.

1990 • 603 citations

In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment.

1993 • 327 citations

CWR22: androgen-dependent xenograft model derived from a primary human prostatic carcinoma.

1994 • 229 citations

Demonstration of a Rational Strategy for Human Prostate Cancer Gene Therapy

1994 • 210 citations

Sustained growth in primary culture of normal mammary epithelial cells embedded in collagen gels

1980 • 165 citations

Xenografts of Primary Human Prostatic Carcinoma

1993 • 152 citations

Particle Bombardment-Mediated Gene Transfer and Expression in Rat Brain Tissues

1993 • 92 citations

Rapid transgene expression in lymphocyte and macrophage primary cultures after particle bombardment-mediated gene transfer

1993 • 84 citations

Cytokine secretion by genetically modified nonimmunogenic murine fibrosarcoma. Tumor inhibition by IL-2 but not tumor necrosis factor.

1993 • 83 citations

Gene Therapy for Cancer

1992 • 82 citations

New strategies for active immunotherapy with genetically engineered tumor cells

1992 • 66 citations

Gene Transfer into Mammalian Somatic Cells in Vivo

1992 • 62 citations

Transient promoter activity in primary rat mammary epithelial cells evaluated using particle bombardment gene transfer

1993 • 60 citations

Growth of human mammary epithelial cells on collagen gel surfaces.

1981 • 59 citations

Cytokines and cancer: experimental systems

1991 • 56 citations

Development of Micrometastases: Earliest Events Detected With Bacterial lacZ Gene-Tagged Tumor Cells

1990 • 41 citations

Separation of cells with histochemically demonstrable acid phosphatase activity from suspensions of cells from human prostatic carcinomas in an isokinetic gradient of Ficoll in tissue culture medium.

1976 • 25 citations

Adoptive Immunotherapy Using Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Preventing and Treating Spontaneous Pulmonary Metastases of Syngeneic Dunning Rat Prostate Tumor

1991 • 16 citations

Gene Transfer via Particle Bombardment: Applications of the Accell Gene Gun

1994 • 14 citations