Role of cytokines and inflammatory mediators in tissue destruction

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Plasminogen: Purification from Human Plasma by Affinity Chromatography

1970 • 2,160 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

Cell-Associated Plasminogen Activation: Regulation and Physiological Functions

1988 • 826 citations

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

1990 • 699 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Structural basis of the action of thermolysin and related zinc peptidases

1988 • 675 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Human leukocyte granule elastase: rapid isolation and characterization

1976 • 550 citations

Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.

1986 • 531 citations

Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.

1986 • 484 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development.

1990 • 459 citations

The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.

1990 • 450 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Phagocyte Impotence Caused by an Invasive Bacterial Adenylate Cyclase

1982 • 438 citations

Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression.

1990 • 408 citations

Measurement of interleukin‐1α and ‐1β in gingival crevicular fluid: Implications for the pathogenesis of periodontal disease

1990 • 386 citations

Cellular Biology and Biochemical Mechanism of Bone Resorption

1988 • 383 citations

Interleukin 1 stimulation of collagenase production by cultured fibroblasts.

1983 • 373 citations

Functional characterization of extracellular vesicles produced by Bacteroides gingivalis

1987 • 349 citations

Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.

1989 • 329 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes

1991 • 307 citations

Collagenase Production by Endotoxin-Activated Macrophages

1974 • 303 citations

Three-dimensional Structure of Thermolysin

1972 • 292 citations

Isolated osteoclasts resorb the organic and inorganic components of bone.

1986 • 276 citations

Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells.

1990 • 249 citations

Concanavalin A produces a matrix-degradative phenotype in human fibroblasts. Induction and endogenous activation of collagenase, 72-kDa gelatinase, and Pump-1 is accompanied by the suppression of the tissue inhibitor of matrix metalloproteinases.

1990 • 235 citations

Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources

1985 • 215 citations

Macrophage Activation by Mycobacterial Water Soluble Compounds and Synthetic Muramyl Dipeptide

1979 • 209 citations

Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor.

1985 • 199 citations

Selected characteristics of pathogenic and nonpathogenic strains of Bacteroides gingivalis

1987 • 196 citations

Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes

1988 • 192 citations

Collagenolytic activity associated with Bacteroides species and Actinobacillus actinomycetemcomitans

1982 • 191 citations

Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides

1991 • 186 citations

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C

1990 • 170 citations

Pig interleukin 1 (Catabolin) is a potent stimulator of bone resorptionin vitro

1985 • 166 citations

Structure of Thermolysin

1972 • 163 citations

The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts

1991 • 160 citations

Periodontal disease pathogens and host immune responses

1993 • 154 citations

Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: Evidence that breakdown is mediated by metal loproteinases

1989 • 150 citations

Degradation of the human proteinase inhibitors alpha-1-antitrypsin and alpha-2-macroglobulin by Bacteroides gingivalis

1984 • 147 citations

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

1992 • 146 citations

Phagocytosis and digestion of collagen by gingival fibroblasts in vivo: A study of serial sections

1981 • 146 citations

Degradation of basement membrane laminin by human neutrophil elastase and cathepsin G.

1990 • 143 citations

Salivary collagenase. Origin, characteristics and relationship to periodontal health

1990 • 142 citations

Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone

1986 • 140 citations

Functional role of interleukin 1 in periodontal disease: induction of interleukin 1 production by Bacteroides gingivalis lipopolysaccharide in peritoneal macrophages from C3H/HeN and C3H/HeJ mice

1985 • 138 citations

Characterization of collagenolytic activity from strains of Bacteroides gingivalis

1988 • 132 citations

Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: Correlation with periodontal disease activity in adult and juvenile periodontitis

1990 • 131 citations

Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes.

1993 • 126 citations

Synthesis of collagenase and collagenase inhibitors by osteoblast-like cells in culture

1984 • 125 citations

Epidermal growth factor stimulation of stromelysin mRNA in rat fibroblasts requires induction of proto-oncogenes c-fos and c-jun and activation of protein kinase C.

1990 • 112 citations

Collagenolytic activity in crevicular fluid from patients with chronic adult periodontitis, localized juvenile periodonitis and gingivitis, and from healthy control subjects

1987 • 108 citations

Cytokines and periodontal disease: immunopathological role of interleukins for B cell responses in chronic inflamed gingival tissues.

1993 • 108 citations

Characterization of sodium dodecyl sulfate-stable Bacteroides gingivalis proteases by polyacrylamide gel electrophoresis

1989 • 106 citations

Bacteroides (Porphyromonas) gingivalis fimbriae activate mouse peritoneal macrophages and induce gene expression and production of interleukin-1

1991 • 101 citations

Collagenase and collagenase inhibitor activities in crevicular fluid of patients receiving treatment for localized juvenile periodontitis

1986 • 97 citations

Isolation of a membrane-associated Bacteroides gingivalis glycylprolyl protease

1987 • 94 citations

The Digestion of Phagocytosed Collagen is Inhibited by the Proteinase Inhibitors Leupeptin and E-64

1985 • 91 citations

lnterleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1

1991 • 89 citations

Inactivation of key factors of the plasma proteinase cascade systems by Bacteroides gingivalis

1985 • 89 citations

Bacterial antigens induce collagenase and prostaglandin E2 synthesis in human gingival fibroblasts through a primary effect on circulating mononuclear cells

1987 • 88 citations

Detection of collagenase activity in oral bacteria

1985 • 87 citations

The effect of periodontol proteolytic Bacteroides species on proteins of the human complement system.

1988 • 86 citations

Production of procollagenase by cultured human keratinocytes.

1987 • 86 citations

An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase

1991 • 84 citations

Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4.

1993 • 82 citations

Correlation of collagenolytic enzymes and inhibitors in gingival crevicular fluid with clinical and microscopic changes in experimental periodontitis in the dog

1986 • 81 citations

Monocyte procollagenase and tissue inhibitor of metalloproteinases. Identification, characterization, and regulation of secretion.

1987 • 79 citations

Degradation of cartilage matrix proteoglycan by human neutrophils involves both elastase and cathepsin G.

1991 • 76 citations

Mechanisms of disruption of the articular cartilage surface in inflammation. Neutrophil elastase increases availability of collagen type II epitopes for binding with antibody on the surface of articular cartilage.

1991 • 74 citations

Immunolocalization of collagenase in periodontal disease

1981 • 71 citations

Second Messenger Signaling in the Regulation of Collagenase Production by Osteogenic Sarcoma Cells*

1989 • 64 citations

The site of collagen resorption in the periodontal ligament of the rodent molar

1978 • 62 citations

Enzymatic and antigenic characterization of immunoglobulin A1 proteases from Bacteroides and Capnocytophaga spp

1987 • 61 citations

Mediation of macrophage collagenase production by 3'-5' cyclic adenosine monophosphate.

1980 • 60 citations

Biochemical characterization of Porphyromonas (Bacteroides) gingivalis collagenase

1992 • 54 citations

Metalloproteinases are not Involved in the Phagocytosis of Collagen Fibrils by Fibroblasts

1989 • 51 citations

The Dissolution of Insoluble Bovine Collagens by Cathepsin BI, Collagenolytic Cathepsin and Pepsin: The influence of collagen type, age and chemical purity on susceptibility

1977 • 50 citations

Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures.

1991 • 46 citations

Nature of collagenolytic enzyme and inhibitor activities in crevicular fluid from healthy and inflamed periodontal tissues of beagle dogs

1987 • 43 citations

Regulation of macrophage collagenase, prostaglandin, and fibroblast-activating-factor production by anti-inflammatory agents: Different regulatory mechanisms for tissue injury and repair

1985 • 39 citations

Activation of keratinocyte‐mediated collagen (Type I) breakdown by suspected human periodontopathogen

1984 • 38 citations

The Influence of Dissolved Calcium Salts on the Degradation of Hard-Tissue Collagens by Lysosomal Cathepsins

1987 • 36 citations

Cleavage of proteoglycan aggregate by leucocyte elastase

1992 • 35 citations

A novel method for the detection of TNF-alpha in gingival crevicular fluid.

1993 • 34 citations

Cleavage of Collagen Type X by Human Synovial Collagenase and Neutrophil Elastase

1989 • 29 citations

Cleavage of type VIII collagen by human neutrophil elastase

1992 • 23 citations

Surface location of a Bacteroides gingivalis glycylprolyl protease

1989 • 23 citations