Stem cells in differentiation and neoplasia

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Gene Activity in Early Development

1968 • 1,725 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

1963 • 1,451 citations

DNA Insertion Elements, Plasmids and Episomes

1978 • 1,294 citations

The distribution of colony‐forming cells among spleen colonies

1963 • 894 citations

A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS

1964 • 889 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

1976 • 726 citations

The origin of human cancers

1981 • 653 citations

Transposable elements

1980 • 600 citations

Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion

1981 • 533 citations

Sequences of mouse immunoglobulin light chain genes before and after somatic changes

1978 • 495 citations

Physical separation of hemopoietic stem cells from cells forming colonies in culture

1969 • 407 citations

The molecular basis of antibody formation: a paradox.

1965 • 394 citations

Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor state

1981 • 346 citations

Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin.

1977 • 334 citations

Hemopoietic stem cell differentiation

1980 • 333 citations

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes

1981 • 327 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

Chromosome Studies in Human Leukemia. II. Chronic Granulocytic Leukemia

1961 • 314 citations

THE MOLECULAR GENETICS OF HUMAN HEMOGLOBINS

1980 • 306 citations

An immunoglobulin heavy-chain gene is formed by at least two recombinational events

1980 • 306 citations

Origin of retroviruses from cellular moveable genetic elements

1980 • 300 citations

Hemopoietic spleen colony studies

1967 • 286 citations

Comparative leukemia research 1969

1970 • 284 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells

1967 • 280 citations

“Fertile” Intestine Nuclei

1966 • 280 citations

Nuclear transplantation in mus musculus: Developmental potential of nuclei from preimplantation embryos

1981 • 268 citations

Novel expression-linked copies of the genes for variant surface antigens in trypanosomes

1980 • 240 citations

Involvement of the B-lymphoid system in chronic myelogenous leukaemia

1980 • 240 citations

Transforming activity of DNA of chemically transformed and normal cells

1980 • 234 citations

Structure and in Vitro Transcription of Human Globin Genes

1980 • 231 citations

Transposable elements associated with constitutive expression of yeast alcohol dehydrogenase II

1981 • 214 citations

Phase Variation: Evolution of a Controlling Element

1980 • 183 citations

Serial Transplantation of Embryonic Nuclei

1956 • 171 citations

Colony formation in agar by multipotential hemopoietic cells

1979 • 159 citations

Self-renewal of hemopoietic stem cells during mixed colony formation in vitro.

1981 • 153 citations

Immunology '80—Progress in Immunology IV

1982 • 145 citations

The Molecular Genetics of Development

1980 • 143 citations

On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses.

1981 • 129 citations

Gene duplication and transposition linked to antigenic variation in Trypanosoma brucei.

1981 • 127 citations

TRANSPOSABLE ELEMENTS IN DROSOPHILA AND OTHER DIPTERA

1980 • 125 citations

Density distribution analysis of In vivo and In vitro colony forming cells in bone marrow

1970 • 120 citations

Analysis of rat hemopoietic cells on the fluorescence-activated cell sorter. I. Isolation of pluripotent hemopoietic stem cells and granulocyte-macrophage progenitor cells

1980 • 107 citations

?Target? cells, cellular phenotypes, and lineage fidelity in human leukaemia

1982 • 99 citations

Insertion of a New Gene of Viral Origin into Bone Marrow Cells of Mice

1980 • 97 citations

CHROMOSOME ABNORMALITIES IN HUMAN LEUKEMIA

1980 • 85 citations

Investigations of a stochastic model of haemopoiesis.

1973 • 84 citations

Cloning--nuclear transplantation in Amphibia

1978 • 67 citations

Is Somatic Mutation the Major Mechanism of Malignant Transformation?

1980 • 61 citations

Disorders of Human Hemoglobin

1980 • 59 citations

Purification of hemopoietic progenitor cells from human marrow using a fucose-binding lectin and cell sorting

1980 • 59 citations

ANTIGENIC DIFFERENCES BETWEEN HEMOPOIETIC STEM CELLS AND MYELOID PROGENITORS

1974 • 58 citations

Chromosome Mediated Gene Transfer

1981 • 58 citations

Some General Questions about Movable Elements and Their Implications

1981 • 56 citations

In vitro methods in haemopoiesis and lymphopoiesis

1980 • 52 citations

Free Flow Electrophoretic Separation of Bone Marrow Cells. Electrophoretic Distribution Analysis ofIn VivoColony Forming Cells in Mouse Bone Marrow

1972 • 49 citations

Analysis of the Functional Components of the Phase Variation System

1981 • 42 citations

Regulation of Hemopoietic Stem Cells

1976 • 41 citations

Philadelphia chromosome (Ph1)-negative chronic myelogenous leukemia (CML): a clonal disease with origin in a multipotent stem cell

1980 • 39 citations

Characterization and enrichment of murine hemopoietic stem cells by fluorescence activated cell sorting.

1981 • 38 citations

Differentiation-linked expression of cell surface markers on HL-60 leukemic cells

1980 • 38 citations

Transposable elements and chromosomal rearrangements in cancer — a possible link

1979 • 26 citations

Expression of an antigen receptor on T cells does not require recombination at the immunoglobulin JH-C mu locus.

1981 • 25 citations

Response : Carcinogenicity Tests

1976 • 22 citations

The role of independent and dependent stem cells in the control of hemopoietic and immunologic responses.

1965 • 20 citations

Surface antigens of murine hemopoietic stem cells. II. Rosetting method used to compare the cross-reactivity of antisera against mouse brain, sperm, and testis cells with bone marrow stem cells and progenitor cells.

1980 • 16 citations

The Long Terminal Repeat of Moloney Sarcoma Provirus

1981 • 15 citations

Cellular diversity in the blood-forming system.

1981 • 7 citations

Thalassaemia: from theory to practice

1981 • 7 citations

Agricultural Research System

1976 • 6 citations

Hemopoietic stem cells bear sperm-associated antigens.

1979 • 6 citations

Summary

1981 • 3 citations