Myc Is an Essential Negative Regulator of Platelet-Derived Growth Factor Beta Receptor Expression

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

MYC oncogenes and human neoplastic disease

1999 • 1,146 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation

1984 • 785 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line

1982 • 727 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Growth factors and wound healing: Biochemical properties of growth factors and their receptors

1993 • 650 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

1997 • 447 citations

Modulation of firefly luciferase stability and impact on studies of gene regulation

1991 • 437 citations

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights

1998 • 381 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Negative autoregulation of c-myc transcription.

1990 • 247 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.

1994 • 227 citations

Toso, a Cell Surface, Specific Regulator of Fas-Induced Apoptosis in T Cells

1998 • 224 citations

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

1988 • 220 citations

The basic region/helix – loop – helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation

1999 • 206 citations

Platelet‐derived Growth Factor

1995 • 200 citations

c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets

1998 • 173 citations

An E-Box-Mediated Increase in cad Transcription at the G₁/S-Phase Boundary Is Suppressed by Inhibitory c-Myc Mutants

1995 • 169 citations

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.

1991 • 166 citations

Myc represses the growth arrest gene gadd45

1997 • 149 citations

Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis

1998 • 120 citations

Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc.

1996 • 113 citations

Negative autoregulation of c-myc gene expression is inactivated in transformed cells.

1990 • 112 citations

Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF

1990 • 109 citations

The Myc Negative Autoregulation Mechanism Requires Myc-Max Association and Involves the c-myc P2 Minimal Promoter

1997 • 104 citations

Mechanism of action of platelet-derived growth factor

1996 • 99 citations

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

1990 • 94 citations

Signal transduction by the PDGF receptors

1994 • 93 citations

Platelet‐derived growth factor: Morphologic and biochemical studies of binding, internalization, and degradation

1984 • 88 citations

Surface binding and internalization of platelet-derived growth factor in human fibroblasts.

1983 • 87 citations

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

1998 • 85 citations

C-MYC: evidence for multiple regulatory functions.

1990 • 79 citations

PDGF-AA and its receptor influence early lung branching via an epithelial–mesenchymal interaction

1995 • 78 citations

A link between c-Myc-mediated transcriptional repression and neoplastic transformation.

1996 • 68 citations

Cell Cycle-dependent Switch of Up- and Down-regulation of Human hsp70 Gene Expression by Interaction between c-Myc and CBF/NF-Y

1999 • 67 citations

c-myc expression correlates with suppression of c-kit protooncogene expression in small cell lung cancer cell lines.

1993 • 64 citations

An Essential Domain of the c-Myc Protein Interacts with a Nuclear Factor That Is Also Required for E1A-Mediated Transformation

1995 • 63 citations

Negative regulation of c-myc transcription involves myc family proteins.

1988 • 55 citations

A cell culture model system for genetic analyses of the cell cycle by targeted homologous recombination.

1993 • 51 citations

Repression of Platelet-Derived Growth Factor β-Receptor Expression by Mitogenic Growth Factors and Transforming Oncogenes in Murine 3T3 Fibroblasts

1995 • 46 citations

Isolation and Characterization of the Mouse PDGF β-Receptor Promoter

1995 • 43 citations

Platelet-derived growth factor in human malignancy.

1992 • 42 citations

Myc Inhibits CCAAT/Enhancer‐Binding Protein α‐Gene Expression in HIB‐1B Hibernoma Cells Through Interactions with the Core Promoter Region

1995 • 33 citations

Myeloblastic leukemia cells conditionally blocked by myc-estrogen receptor chimeric transgenes for terminal differentiation coupled to growth arrest and apoptosis

1993 • 29 citations

Myeloblastic leukemia cells conditionally blocked by myc-estrogen receptor chimeric transgenes for terminal differentiation coupled to growth arrest and apoptosis

1993 • 28 citations

Nuclear Factor Y Controls the Basal Transcription Activity of the Mouse Platelet‐Derived‐Growth‐Factor β‐Receptor Gene

1997 • 21 citations

Dysfunction of the Myc-induced apoptosis mechanism accompanies c-myc activation in the tumorigenic L929 cell line.

1994 • 11 citations

c-myc Repression of Promoter Activity through Core Promoter Elements

1993 • 6 citations

Reduction in platelet-derived growth factor receptor mRNA in v-src-transformed fibroblasts

1995 • 6 citations