T:T Antigen Presentation by Activated Murine CD8+ T Cells Induces Anergy and Apoptosis

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Differential Requirements for Survival and Proliferation of CD8 Naïve or Memory T Cells

1997 • 875 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

1993 • 595 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Co-stimulation in T cell responses

1997 • 430 citations

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

1987 • 391 citations

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

1990 • 360 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Human Influence on the Atmospheric Vertical Temperature Structure: Detection and Observations

1996 • 289 citations

Functional expression of B7/BB1 on activated T lymphocytes.

1993 • 271 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

The role of cell division in the induction of clonal anergy

1992 • 203 citations

Programmed Cell Death of T Cells Signaled by the T Cell Receptor and the α₃Domain of Class I MH

1991 • 196 citations

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

1996 • 195 citations

Identification of a mouse male-specific transplantation antigen, H-Y

1995 • 192 citations

Veto Cells

1988 • 150 citations

Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction

1984 • 117 citations

B7/BB1, the ligand for CD28, is expressed on repeatedly activated human T cells in vitro

1993 • 117 citations

In vitro induction of T cell anergy by blocking B7 and early T cell costimulatory molecule ETC-1/B7-2

1994 • 109 citations

Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?

1995 • 104 citations

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.

1990 • 96 citations

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

1993 • 95 citations

The veto phenomenon and T-cell regulation

1986 • 81 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

1995 • 78 citations

MHC class I ligation of human T cells activates the ZAP70 and p56lck tyrosine kinases, leads to an alternative phenotype of the TCR/CD3 zeta-chain, and induces apoptosis.

1997 • 78 citations

Human T cells cannot act as autonomous antigen-presenting cells, but induce tolerance in antigen-specific and alloreactive responder cells.

1992 • 74 citations

Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide.

1993 • 68 citations

Antigen receptor-mediated anergy in resting T lymphocytes and T cell clones. Correlation with lymphokine secretion patterns.

1992 • 62 citations

Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro

1997 • 55 citations

Antigen presentation by T cells inhibits IL-2 production and induces IL-4 release due to altered cognate signals.

1996 • 52 citations

Inactivation of human immunodeficiency virus (HIV)-1 envelope-specific CD8+ cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism?

1996 • 52 citations

T cell-T cell killing is induced by specific epitopes: evidence for an apoptotic mechanism.

1991 • 50 citations

The combination of anti-B7 monoclonal antibody and cyclosporin A induces alloantigen-specific anergy during a primary mixed lymphocyte reaction.

1994 • 47 citations

Induction of anergy in resting human T lymphocytes by immobilized anti‐CD3 antibodies

1994 • 41 citations

Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites

1996 • 40 citations

Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells

1995 • 37 citations

Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells.

1990 • 29 citations

Minireview The role of anergy in peripheral T cell unresponsiveness

1994 • 28 citations

Reduction of CTL antipeptide response mediated by CD8+ cells whose class I MHC can bind the peptide.

1994 • 27 citations

MHC class II Ab diabetogenic residue 57 Asp/non-Asp dimorphism influences T-cell recognition and selection

1998 • 17 citations

Mapping minor H genes.

1989 • 9 citations