T cell-T cell killing is induced by specific epitopes: evidence for an apoptotic mechanism.

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.

1983 • 616 citations

Death and the cell

1986 • 616 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 602 citations

Biological Activity of Recombinant Human Interleukin-2 Produced in Escherichia coli

1984 • 600 citations

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules.

1985 • 398 citations

Site-Specific Mutagenesis of the Human Interleukin-2 Gene: Structure-Function Analysis of the Cysteine Residues

1984 • 328 citations

A novel serine esterase expressed by cytotoxic T lymphocytes

1985 • 319 citations

Geographical prevalence of two types of Epstein-Barr virus

1986 • 290 citations

Cytotoxic T-cell clones discriminate between A- and B-type Epstein-Barr virus transformants

1988 • 194 citations

An Epstein-Barr virus-specific cytotoxic T cell epitope in EBV nuclear antigen 3 (EBNA 3).

1990 • 173 citations

Granules of cytolytic T-lymphocytes contain two serine esterases.

1986 • 148 citations

Cytotoxic T‐Lymphocytes How Do They Function?

1983 • 124 citations

Cognate peptides induce self-destruction of CD8+ cytolytic T lymphocytes.

1990 • 96 citations

Specific killing of cytotoxic T cells and antigen-presenting cells by CD4+ cytotoxic T cell clones. A novel potentially immunoregulatory T-T cell interaction in man.

1990 • 95 citations

Multiple mechanisms of lymphocyte-mediated killing

1988 • 90 citations

Resistance of cloned cytotoxic T lymphocytes to cell-mediated cytotoxicity.

1987 • 89 citations

An Epstein-Barr virus-specific cytotoxic T-cell epitope present on A- and B-type transformants

1990 • 80 citations

Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro.

1988 • 79 citations

Evidence for multiple lytic pathways used by cytotoxic T lymphocytes.

1989 • 74 citations

Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granules.

1987 • 71 citations

T-lymphocyte-mediated cytolysis as an excitatory process of the target

1985 • 71 citations

Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes.

1987 • 70 citations

Cell death by apoptosis in acute leukaemia

1989 • 69 citations

Resistance of cytolytic lymphocytes to perforin-mediated killing. Lack of correlation with complement-associated homologous species restriction.

1988 • 54 citations

Cytolytic T-cell melodrama

1987 • 51 citations

Perforin mRNA in primary peritoneal exudate cytotoxic T lymphocytes.

1989 • 43 citations

Resistance of mouse cytolytic cells to pore‐forming protein‐mediated cytolysis

1988 • 41 citations

The most efficient cytotoxic T lymphocytes are the least susceptible to lysis.

1987 • 41 citations

Are lytic granules and perforin 1 involved in lysis induced by in vivo-primed peritoneal exudate cytolytic T lymphocytes?

1987 • 37 citations

Resistance of primary CD8+ cytotoxic T lymphocytes to lysis by cytotoxic granules from cloned T cell lines.

1988 • 33 citations

Influenza peptide-induced self-lysis and down-regulation of cloned cytotoxic T cells.

1990 • 29 citations

Mechanism of Lymphocyte-Mediated Cytotoxicity

1985 • 28 citations

The lysis of cytotoxic T lymphocytes and their blasts by cytotoxic T lymphocytes.

1990 • 18 citations

Cell-mediated and glucocorticoid-mediated target cell lysis do not appear to share common pathways

1988 • 7 citations

Cell-mediated and glucocorticoid-mediated target cell lysis do not appear to share common pathways.

1988 • 7 citations