Retrograde signaling in the formation and maintenance of the neuromuscular junction

Cell Death During Development of the Nervous System

1991 • 3,033 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons

1992 • 895 citations

Synaptic structure and development: The neuromuscular junction

1993 • 846 citations

Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF

1993 • 753 citations

Firing patterns of motor units in normal rats

1985 • 723 citations

Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin

1992 • 669 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Reinnervation of muscle fiber basal lamina after removal of myofibers. Differentiation of regenerating axons at original synaptic sites.

1978 • 577 citations

A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction

1989 • 566 citations

Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo

1993 • 537 citations

Motor Nerve Sprouting

1981 • 525 citations

Multiple forms of acetylcholinesterase and their distribution in endplate and non‐endplate regions of rat diaphragm muscle

1973 • 505 citations

Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

1986 • 472 citations

Cloning and Expression of a Developmentally Regulated Protein That Induces Mitogenic and Neurite Outgrowth Activity

1990 • 468 citations

The formation of synapses in striated muscle during development

1974 • 465 citations

Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death

1992 • 458 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release

1993 • 448 citations

Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors.

1990 • 441 citations

Spontaneous release of transmitter from growth cones of embryonic neurones

1983 • 436 citations

Strategic location of calcium channels at transmitter release sites of frog neuromuscular synapses

1990 • 398 citations

The neurotrophic theory and naturally occurring motoneuron death

1989 • 397 citations

Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels

1991 • 394 citations

Neural cell adhesion molecules influence second messenger systems

1989 • 387 citations

Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family.

1988 • 382 citations

Morphological plasticity of motor axons in Drosophila mutants with altered excitability

1990 • 381 citations

Observations on the elimination of polyneuronal innervation in developing mammalian skeletal muscle.

1978 • 363 citations

Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes

1983 • 356 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses.

1979 • 348 citations

Effects of innervation on the distribution of acetylcholine receptors on cultured muscle cells.

1977 • 338 citations

Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.

1985 • 332 citations

Myogenin and MyoD join a family of skeletal muscle genes regulated by electrical activity.

1991 • 314 citations

Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes

1986 • 312 citations

Development of neuromuscular junctions in rat embryos

1981 • 310 citations

Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle.

1986 • 307 citations

THE FINE STRUCTURE OF MOTOR ENDPLATE MORPHOGENESIS

1969 • 305 citations

In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle

1989 • 290 citations

In vivo observations of pre- and postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions

1993 • 275 citations

Distribution of Na+ channels and ankyrin in neuromuscular junctions is complementary to that of acetylcholine receptors and the 43 kd protein

1989 • 274 citations

Purified N-cadherin is a potent substrate for the rapid induction of neurite outgrowth.

1990 • 273 citations

Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade

1992 • 270 citations

Visualization of neuromuscular junctions over periods of several months in living mice

1987 • 270 citations

Changes in contractile properties of disused soleus muscles

1969 • 255 citations

Molecular cloning of the 18-kDa growth-associated protein of developing brain.

1990 • 255 citations

Development of the myotomal neuromuscular junction in Xenopus laevis: An electrophysiological and fine-structural study

1977 • 253 citations

Repression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate.

1992 • 241 citations

Development of the embryonic neuromuscular synapse of Drosophila melanogaster

1993 • 240 citations

The effect of prolonged, reversible block of nerve impulses on the elimination of polyneuronal innervation of new-born rat skeletal muscle fibers

1979 • 230 citations

In vivo visualization of the growth of pre- and postsynaptic elements of neuromuscular junctions in the mouse

1990 • 229 citations

Acetylcholine receptor α-, β-, γ-, and δ-subunit mRNA levels are regulated by muscle activity

1988 • 224 citations

Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers.

1983 • 224 citations

Distinct roles for adhesion molecules during innervation of embryonic chick muscle

1988 • 219 citations

Ultrastructure of neuromuscular junctions in Drosophilal: Comparison of wild type and mutants with increased excitability

1993 • 215 citations

Precision of reinnervation of original postsynaptic sites in frog muscle after a nerve crush

1976 • 209 citations

Neural cell adhesion molecules modulate tyrosine phosphorylation of tubulin in nerve growth cone membranes

1992 • 197 citations

Development of the Neuromuscular Junction: Inductive Interactions Between Cells

1981 • 196 citations

Primary sequence of a motor neuron-selective adhesive site in the synaptic basal lamina protein s-laminin

1989 • 194 citations

The Neurotrophins BDNF, NT‐3 and NT‐4/5, But Not NGF, Up‐regulate the Cholinergic Phenotype of Developing Motor Neurons

1993 • 192 citations

Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.

1983 • 191 citations

Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscle.

1986 • 190 citations

Initial events in the formation of neuromuscular synapse: rapid induction of acetylcholine release from embryonic neuron.

1986 • 189 citations

Extracellular matrix organization in developing muscle: correlation with acetylcholine receptor aggregates.

1984 • 184 citations

Consequences of tenotomy on the evolution of multiineervation in developing rat soleus muscle

1975 • 183 citations

Fibroblasts that proliferate near denervated synaptic sites in skeletal muscle synthesize the adhesive molecules tenascin(J1), N-CAM, fibronectin, and a heparan sulfate proteoglycan.

1989 • 183 citations

N-CAM at the vertebrate neuromuscular junction.

1985 • 179 citations

Agrin-like molecules at synaptic sites in normal, denervated, and damaged skeletal muscles.

1987 • 177 citations

Regulation of Ion Channel Distribution at Synapses

1993 • 177 citations

Distribution of Ca2+ channels on frog motor nerve terminals revealed by fluorescent omega-conotoxin

1991 • 176 citations

Calcium-induced release of calcium regulates differentiation of cultured spinal neurons

1991 • 175 citations

Basic fibroblast growth factor in the chick embryo: immunolocalization to striated muscle cells and their precursors.

1989 • 172 citations

Triggering signaling cascades by receptor tyrosine kinases

1992 • 168 citations

Studies of nerve-muscle interactions in Xenopus cell culture: analysis of early synaptic currents

1989 • 166 citations

Synapse elimination in neonatal rat muscle is sensitive to pattern of muscle use

1983 • 161 citations

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture

1986 • 157 citations

Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila

1993 • 156 citations

Cellular mechanisms governing synaptic development in Drosophila melanogaster

1993 • 153 citations

Sprouting and remodelling at the nerve-muscle junction

1986 • 151 citations

The regulation of synaptogenesis during normal development and following activity blockade

1991 • 149 citations

Morphological transformation of synaptic terminals of a phasic motoneuron by long-term tonic stimulation

1986 • 147 citations

Evoked release of acetylcholine from the growing embryonic neuron.

1987 • 144 citations

Internal and external differentiations of the postsynaptic membrane at the neuromuscular junction

1982 • 144 citations

Reduction of multiaxonal innervation at the neuromuscular junction of the rat during development.

1977 • 140 citations

Spontaneous calcium influx and its roles in differentiation of spinal neurons in culture

1990 • 135 citations

Motoneurons purified by cell sorting respond to two distinct activities in myotube-conditioned medium

1984 • 133 citations

Activity-dependent regulation of gene expression in muscle and neuronal cells

1989 • 133 citations

The distribution of NCAM in the chick hindlimb during axon outgrowth and synaptogenesis

1986 • 129 citations

The coordinated regulation of heparan sulfate, syndecans and cell behavior

1993 • 129 citations

Studies of nerve-muscle interactions in Xenopus cell culture: fine structure of early functional contacts

1989 • 128 citations

Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: in vivo observations in the androgen-sensitive bulbocavernosus muscle of mice

1990 • 123 citations

Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein.

1992 • 118 citations

Cellular distribution of the new growth factor Pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues

1992 • 114 citations

Development of basal lamina in synaptic and extrasynaptic portions of embryonic rat muscle

1984 • 113 citations

An LRE (leucine-arginine-glutamate)-dependent mechanism for adhesion of neurons to S-laminin

1991 • 111 citations

The role of muscle activity in the differentiation of neuromuscular junctions in slow and fast chick muscles

1978 • 111 citations

Control of ACh Sensitivity in Rat Muscle Fibers

1976 • 111 citations

Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscle

1986 • 108 citations

Lectin binding reveals a synapse-specific carbohydrate in skeletal muscle

1982 • 108 citations

Release of acetylcholine from embryonic neurons upon contact with muscle cell

1985 • 106 citations

The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells

1995 • 101 citations

The release of adenosine triphosphate from frog skeletal muscle in vitro

1968 • 101 citations

Survival in vitro of motoneurons identified or purified by novel antibodybased methods is selectively enhanced by muscle-derived factors

1991 • 99 citations

Onset of acetylcholine sensitivity and endplate activity in developing myotome muscles of Xenopus

1976 • 99 citations

Distinct neurotrophic factors from skeletal muscle and the central nervous system interact synergistically to support the survival of cultured embryonic spinal motor neurons

1987 • 90 citations

Characterization and localization of the Mr = 43,000 proteins associated with acetylcholine receptor-rich membranes.

1983 • 89 citations

TTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation

1991 • 86 citations

Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmentally regulated.

1990 • 85 citations

The development of functional neuromuscular junctionsin vitro: An ultrastructural and physiological study

1980 • 85 citations

The expression and localization of synaptic vesicle antigens at neuromuscular junctions in vitro

1985 • 82 citations

Cell accumulation in the junctional region of denervated muscle.

1987 • 81 citations

Localization of acetylcholine receptors by means of horseradish peroxidase-alpha-bungarotoxin during formation and development of the neuromuscular junction in the chick embryo

1979 • 80 citations

Motor nerve terminal loss from degenerating muscle fibers

1989 • 79 citations

Initial synaptic transmission at the growth cone in Xenopus nerve-muscle cultures.

1982 • 78 citations

ATP potentiates spontaneous transmitter release at developing neuromuscular synapses

1991 • 76 citations

Differentiation of motor nerve terminals formed in the absence of muscle fibres

1983 • 75 citations

Remodeling of neuromuscular junctions in adult mouse soleus

1989 • 71 citations

Development of larval muscle properties in the embryonic myotubes of Drosophila melanogaster

1993 • 71 citations

Restoration of focal multiple innervation in rat muscles by transmission block during a critical stage of development

1981 • 70 citations

Agrin and the molecular choreography of synapse formation

1993 • 69 citations

The Formation of Neuromuscular Synapses

1976 • 68 citations

Axotomy-induced neurofilament phosphorylation is inhibited in situ by micromjection of PKA and PKC inhibitors into identified lamprey neurons

1993 • 68 citations

Interactions between Nerve and Muscle: Synapse Elimination at the Developing Neuromuscular Junction

1993 • 68 citations

The absence of calcium blocks impulse-evoked release of acetylcholine but not de novo formation of functional neuromuscular synaptic contacts in culture

1984 • 67 citations

Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses

1991 • 66 citations

Structure and physiology of developing neuromuscular synapses in culture

1987 • 65 citations

Repeated,in vivo observation of frog neuromuscular junctions: remodelling involves concurrent growth and retraction

1990 • 63 citations

Developmental changes in the distribution of acetylcholine receptors in the myotomes of Xenopus laevis.

1983 • 60 citations

Mr 42,000 ARIA: A Protein That May Regulate the Accumulation of Acetylcholine Receptors at Developing Chick Neuromuscular Junctions

1990 • 60 citations

Motor neurotrophic factor in denervated adult skeletal muscle

1982 • 58 citations

Neural regulation of N-cadherin gene expression in developing and adult skeletal muscle

1992 • 58 citations

Nerve dependent regulation of neural cell adhesion molecule expression in skeletal muscle

1986 • 58 citations

Synaptic target contact enhances presynaptic calcium influx by activating CAMP-dependent protein kinase during synaptogenesis

1993 • 57 citations

Effects of antibodies to neural cell adhesion molecule (N-CAM) on the differentiation of neuromuscular contacts between ciliary ganglion neurons and myotubes in vitro

1987 • 54 citations

Elevation in presynaptic Ca2+ level accompanying initial nerve-muscle contact in tissue culture

1993 • 54 citations

Activity-dependent accumulation of basal lamina by cultured rat myotubes

1983 • 54 citations

Mechanisms of elimination, remodeling, and competition at frog neuromuscular junctions

1990 • 53 citations

Retrograde modulation at developing neuromuscular synapses: Involvement of G protein and arachidonic acid cascade

1992 • 52 citations

Nerve terminal anchorage protein 1 (TAP-1) is a chondroitin sulfate proteoglycan: biochemical and electron microscopic characterization.

1987 • 51 citations

Tenotomy delays the postnatal development of the motor innervation of the rat soleus

1978 • 51 citations

Filopodia, lamellipodia and retractions at mouse neuromuscular junctions

1988 • 51 citations

The remodeling of synaptic extracellular matrix and its dynamic relationship with nerve terminals at living frog neuromuscular junctions

1991 • 50 citations

Neuron-Muscle Contact Changes Presynaptic Resting Calcium Set-Point

1993 • 49 citations

Extension of synaptic extracellular matrix during nerve terminal sprouting in living frog neuromuscular junctions

1994 • 48 citations

Spatial distribution of acetylcholine receptors at developing chick neuromuscular junctions

1983 • 45 citations

Impulse activity of a crayfish motoneuron regulated its neuromuscular synaptic properties

1989 • 45 citations

The current status of peripheral nerve regeneration

1988 • 42 citations

Regeneration of the active zone at the frog neuromuscular junction.

1984 • 42 citations

Autoradiographic localization of voltage-dependent sodium channels on the mouse neuromuscular junction using 125I-alpha scorpion toxin. II. Sodium distribution on postsynaptic membranes

1992 • 40 citations

S-Laminin

1990 • 37 citations

Early nerve-muscle synapses in vitro release transmitter over postsynaptic membrane having low acetylcholine sensitivity.

1980 • 35 citations

Development of presynaptic specializations induced by basic polypeptide‐coated latex beads in spinal cord cultures

1987 • 27 citations

The Elimination of Polyneuronal Innervation of End-Plates in Developing Rat Muscles with Altered Function

1979 • 27 citations

Slowing of synapse elimination by α-bungarotoxin superfusion of the neonatal rabbit soleus muscle

1989 • 21 citations

A novel epitope of entactin is present at the mammalian neuromuscular junction

1994 • 17 citations

Muscle of adult rats and mice express the Thy-1 glycoprotein on denervation

1984 • 15 citations

Postmetamorphic development of neuromuscular junctions and muscle fibers in the frog cutaneous pectoris

1991 • 14 citations

Recycling of synaptic vesicles in motor nerve endings separated from their target muscle fibers

1983 • 13 citations

Neuromuscular junction development in the cutaneous pectoris muscle of Rana catesbeiana

1988 • 13 citations

Receptors to agglutinin fromDolichus biflorus (DBA) at the synaptic basal lamina of rat neuromuscular junction

1987 • 12 citations

Modulation of Presynaptic Transmitter Release by ATP Derived from Postsynaptic Sources

1986 • 7 citations