Activation of the Nuclear Receptor Peroxisome Proliferator-activated Receptor γ Promotes Brown Adipocyte Differentiation

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

Thermogenic mechanisms in brown fat.

1984 • 1,593 citations

A role for brown adipose tissue in diet-induced thermogenesis

1979 • 1,587 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

1993 • 1,166 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

1994 • 935 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 • 638 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

1983 • 476 citations

Brown adipose tissue thermogenesis: interdisciplinary studies

1990 • 462 citations

36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO

1991 • 432 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR7 and RXRa

1994 • 380 citations

Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.

1993 • 371 citations

Brown adipose tissue thermogenesis and obesity

1989 • 329 citations

The uncoupling protein ucp: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue

1991 • 287 citations

Differentiation-Dependent Expression of the Brown Adipocyte Uncoupling Protein Gene: Regulation by Peroxisome Proliferator-Activated Receptor γ

1996 • 271 citations

New Antidiabetic Drugs

1990 • 213 citations

Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.

1996 • 208 citations

A Novel Regulatory Pathway of Brown Fat Thermogenesis

1995 • 188 citations

A direct role for C/EBP and the AP-I-binding site in gene expression linked to adipocyte differentiation.

1989 • 170 citations

An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.

1994 • 169 citations

Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.

1991 • 135 citations

Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

1994 • 135 citations

Effect of High Fat Diets on Energy Balance and Thermogenesis in Brown Adipose Tissue of Lean and Genetically Obese ob/ob Mice

1987 • 135 citations

Pioglitazone Increases Insulin Sensitivity, Reduces Blood Glucose, Insulin, and Lipid Levels, and Lowers Blood Pressure, in Obese, Insulin-Resistant Rhesus Monkeys

1994 • 133 citations

Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

1992 • 124 citations

Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene.

1995 • 117 citations

In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets1, retinoid X receptor, thyroid hormone receptor, and a CACCC box-binding protein.

1994 • 94 citations

Peroxisome Proliferator‐Activated Receptors and Lipid Metabolism^a

1993 • 87 citations

Characterization of Insulin Resistance and NIDDM in Transgenic Mice With Reduced Brown Fat

1995 • 84 citations

Characterization of the novel brown adipocyte cell line hib 1b adrenergic pathways involved in regulation of uncoupling protein gene expression

1994 • 71 citations

Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice

1986 • 36 citations

Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat

1987 • 30 citations

Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice

1987 • 24 citations

Some aspects of the relationship between body weight and sexual behaviour with particular reference to massive obesity and anorexia nervosa.

1978 • 14 citations