Should morbidity replace mortality as an endpoint for clinical trials in intensive care?

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

1987 • 1,434 citations

Cumulative Meta-Analysis of Therapeutic Trials for Myocardial Infarction

1992 • 1,132 citations

A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease

1989 • 1,087 citations

A new measure of health status for clinical trials in inflammatory bowel disease

1989 • 653 citations

Efficacy of antibiotic prophylaxis for prevention of native-valve endocarditis

1992 • 350 citations

Reduction of Mortality in Chloramphenicol-Treated Severe Typhoid Fever by High-Dose Dexamethasone

1984 • 317 citations

Effect of Preoperative Neornycin-Erythromycin Intestinal Preparation on the Incidence of Infectious Complications Following Colon Surgery

1973 • 277 citations

National estimates of intensive care utilization and costs

1990 • 250 citations

Enteral nutrition in the critically ill patient: A critical review of the evidence

1993 • 229 citations

Anti-TNF therapy inhibits fever in cerebral malaria

1993 • 206 citations

The Clinical Evaluation of New Drugs for Sepsis

1993 • 202 citations

Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans.

1994 • 190 citations

Measuring Functional Outcomes in Chronic Disease: A Comparison of Traditional Scales and a Self- Administered Health Status Questionnaire in Patients With Rheumatoid Arthritis

1983 • 161 citations

Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.

1991 • 158 citations

Identification of futility in intensive care

1994 • 154 citations

Renal-dose dopamine: a Siren song?

1994 • 136 citations

Impact of Handwashing on Mortality in Intensive Care: Examination of the Evidence

1994 • 63 citations

Why have new effective therapies for sepsis not been developed?

1994 • 58 citations

Impact of Handwashing on Mortality in Intensive Care: Examination of the Evidence

1994 • 29 citations