Identification and Characterization of Protective T Cells in hsp65 DNA-Vaccinated andMycobacterium tuberculosis-Infected Mice

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Vaccination against tuberculosis by DNA injection

1996 • 513 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

Role of interferon-gamma in immune cell regulation.

1995 • 374 citations

Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.

1993 • 359 citations

CD8+ T lymphocytes in intracellular microbial infections

1988 • 335 citations

Role of interferon-γ in immune cell regulation

1995 • 295 citations

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

1995 • 291 citations

Cytokine patterns of immunologically mediated tissue damage.

1992 • 285 citations

Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis.

1996 • 261 citations

T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. Evidence for different kinetics and recognition of a wide spectrum of protein antigens.

1992 • 256 citations

Protective role of γ/δ T cells and α/β T cells in tuberculosis

1995 • 219 citations

Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64‐kDa protein

1987 • 216 citations

The role of TNF-alpha in T-cell-mediated inflammation depends on the Th1/Th2 cytokine balance.

1994 • 205 citations

The age-associated increase in IFN-gamma synthesis by mouse CD8+ T cells correlates with shifts in the frequencies of cell subsets defined by membrane CD44, CD45RB, 3G11, and MEL-14 expression.

1993 • 168 citations

Immunity to intracellular microbial pathogens

1995 • 152 citations

Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis.

1995 • 148 citations

Role of T Cell Subsets in Immunity against Intracellular Bacteria: Experimental Infections of Knock-Out Mice with Listeria monocytogenes and Mycobacterium bovis BCG

1994 • 127 citations

The functional role of CD8+ T helper type 2 cells.

1995 • 121 citations

Parallel regulation of IL-4 and IL-5 in human helminth infections.

1992 • 108 citations

A single mycobacterial protein (hsp 65) expressed by a transgenic antigen-presenting cell vaccinates mice against tuberculosis.

1994 • 105 citations

Sequential production of Th1 and Th2 cytokines in response to live bacillus Calmette-Guérin.

1995 • 102 citations

Natural killer cells and interferon.

1984 • 95 citations

Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.

1994 • 94 citations

Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.

1989 • 93 citations

A ubiquitous mammalian expression vector, pHMG, based on a housekeeping gene promoter

1989 • 81 citations

Immunoregulatory Effects of Cytokines on Natural Killer Cells

1994 • 72 citations

Characterization of T cells that confer a high degree of protective immunity against tuberculosis in mice after vaccination with tumor cells expressing mycobacterial hsp65

1996 • 56 citations

Evidence for an alpha/beta T cell-independent mechanism of resistance to mycobacteria. Bacillus-Calmette-Guerin causes progressive infection in severe combined immunodeficient mice, but not in nude mice or in mice depleted of CD4+ and CD8+ T cells.

1992 • 55 citations

Apparent killing of Mycobacterium tuberculosis by cytokine-activated human monocytes can be an artefact of a cytotoxic effect on the monocytes

1994 • 30 citations

Growth hormone activation of human monocytes for superoxide production but not tumor necrosis factor production, cell adherence, or action against Mycobacterium tuberculosis

1995 • 29 citations

Major histocompatibility complex class I-restricted T cells are necessary for protection against M. tuberculosis in mice.

1993 • 28 citations

Mycobacterium leprae 65hsp antigen expressed from a retroviral vector in a macrophage cell line is presented to T cells in association with MHC class II in addition to MHC class I

1992 • 28 citations

Protection against tuberculosis by bone marrow cells expressing mycobacterial hsp65.

1995 • 20 citations

The regulation of the development of CD8 effector T cells.

1996 • 18 citations

Differential Effects of IL‐10 on Proliferation and Cytokine Production of Human γ/δ and α/β T cells

1994 • 18 citations