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Novel Pure Antiestrogens. Mode of Action and Therapeutic Prospects

Data up to Jan 2025

Published1990
Citations24
References31

Total Citations Per Year

Abstract

References (31)

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.

1988 • 420 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

STEROIDAL PURE ANTIOESTROGENS

1987 • 313 citations

Antagonism of estrogen action with a new benzothiophene derived antiestrogen

1983 • 244 citations

A NON-STEROIDAL ESTROGEN ANTAGONIST l-(p-2-DIETHYLAMINOETHOXYPHENYLH-PHENYL-2-p-METHOXYPHENYL ETHANOL

1958 • 233 citations

Novel antioestrogens without partial agonist activity

1988 • 215 citations

Novel steroidal pure antiestrogens

1989 • 200 citations

Pharmacology and Clinical Uses of Inhibitors of Hormone Secretion and Action

1988 • 188 citations

Biology and mode of action of pure antioestrogens.

1988 • 149 citations

THE PREVENTION OF BREAST CANCER

1986 • 143 citations

Biology and mode of action of pure antioestrogens

1988 • 136 citations

Species-specific pharmacology of antiestrogens: role of metabolism.

1987 • 131 citations

Tamoxifen stimulation of human breast cancer cell proliferation in vitro: a possible model for tamoxifen tumour flare

1984 • 124 citations

New biospecific adsorbents for the purification of estradiol receptor.

1978 • 120 citations

Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells

1989 • 110 citations

Non-steroidal antioestrogens—Receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells

1984 • 110 citations

Points of action of estrogen antagonists and a calmodulin antagonist within the MCF-7 human breast cancer cell cycle.

1989 • 101 citations

Antioestrogens in the management of hormone-dependent cancer

1988 • 86 citations

Interaction of the antioestrogen ICI 164,384 with the oestrogen receptor

1988 • 73 citations

An Orally Active Compound with Anti-Fertility Effects in Rats.

1958 • 61 citations

Estrogen-receptor binding and biologic activity of tamoxifen and its metabolites.

1980 • 59 citations

Non-steroidal antioestrogens : molecular pharmacology and antitumour activity

1981 • 46 citations

An evaluation of tamoxifen as a partial agonist by classical receptor theory — An explanation of the dual action of tamoxifen

1984 • 46 citations

Actions of oestrogens and antioestrogens on rat mammary gland development: Relevance to breast cancer prevention

1988 • 45 citations

Regulation of pS2 Gene Expression by Affinity Labeling and Reversibly Binding Estrogens and Antiestrogens: Comparison of Effects on the Native Gene and on pS2-Chloramphenicol Acetyltransferase Fusion Genes Transfected into MCF-7 Human Breast Cancer Cells

1988 • 44 citations

A comparative study of the interaction of oestradiol and the steroidal pure antioestrogen, ICI 164,384, with the molybdate-stabilized oestrogen receptor

1990 • 32 citations

Effects of the antioestrogen, ICI 164,384, on oestrogen induced RNAs in MCF-7 cells

1989 • 29 citations

The estrogenic effects of clomiphene during the neonatal period in the rat

1983 • 17 citations

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