Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and Proteomics

Protein structure: A practical approach

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TOR, a Central Controller of Cell Growth

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1994 • 1,222 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

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Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

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Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

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PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin.

1990 • 613 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Rapamycin in transplantation: A review of the evidence

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Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

1996 • 405 citations

Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray

1999 • 387 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

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Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond.

1995 • 341 citations

Identification and Characterization of a Novel Cell Cycle–Regulated Internal Ribosome Entry Site

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The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

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BTG1, a member of a new family of antiproliferative genes.

1992 • 298 citations

Profiling Changes in Gene Expression during Differentiation and Maturation of Monocyte-derived Dendritic Cells Using Both Oligonucleotide Microarrays and Proteomics

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Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

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Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.

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CENP-E as an Essential Component of the Mitotic Checkpoint In Vitro

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Translational Control

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Levels of Polyadenylation Factor CstF-64 Control IgM Heavy Chain mRNA Accumulation and Other Events Associated with B Cell Differentiation

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Rapamycin Sensitivity in Saccharomyces cerevisiae Is Mediated by a Peptidyl-Prolyl cis-trans Isomerase Related to Human FK506-Binding Protein

1991 • 213 citations

Messenger RNA translation state: The second dimension of high-throughput expression screening

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Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.

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Manual of Immunological Methods

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Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF‐κB activation

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Involvement of Proteasomes in Regulating Jak-STAT Pathways upon Interleukin-2 Stimulation

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Cyclin G2 Is Up-regulated during Growth Inhibition and B Cell Antigen Receptor-mediated Cell Cycle Arrest

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Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells

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The Proteasome Regulates Receptor-mediated Endocytosis of Interleukin-2

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Rapamycin: FK506's fraternal twin or distant cousin?

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Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ

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Isolation of translationally controlled mRNAs by differential screening

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Role of Proteasomes in T Cell Activation and Proliferation

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FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

1995 • 74 citations

Expression of the rat prothymosin alpha gene during T-lymphocyte proliferation and liver regeneration

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Sirolimus: Continuing the Evolution of Transplant Immunosuppression

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Effects of Orally Administered Rapamycin in Animal Models of Arthritis and Other Autoimmune Diseases

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Isolation of translationally controlled mRNAs by differential screening

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Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection

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SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract

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Data base analysis of protein expression patterns during T-cell ontogeny and activation.

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A two‐dimensional electrophoresis‐related laboratory information processing system: Spot matching

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8 mRNA 5′ Cap-binding Protein elF4E and Control of Cell Growth

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Rapamycin inhibits proteasome activator expression and proteasome activity

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Enhancement of human T lymphocyte functions by prothymosin α. I. Augmentation of mixed lymphocyte culture reactions and soluble protein-induced proliferative responses

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Prothymosin alpha enhances human natural killer cell cytotoxicity: role in mediating signals for NK activity.

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New treatment possibilities in rheumatoid arthritis: REVIEW

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Promising New Agents in the Prevention of Transplant Rejection

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Proteasome activity is required for T lymphocyte aggregation after mitogen activation

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Reliability of mRNA Profiling: Verification for Samples with Different Complexities

2001 • 10 citations