Back to search

Prognostic factors in breast cancer: current and new predictors of metastasis.

Data up to Jan 2025

Published2001
Citations209
References106

Total Citations Per Year

Abstract

References (106)

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

1991 • 5,979 citations

Tamoxifen for early breast cancer: an overview of the randomised trials

1998 • 4,082 citations

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

1989 • 2,245 citations

Polychemotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

1998 • 2,199 citations

The Sentinel Node in Breast Cancer — A Multicenter Validation Study

1998 • 2,025 citations

Polychemotherapy for early breast cancer: an overview of the randomised trials

1998 • 2,023 citations

Tumor Angiogenesis: A New Significant and Independent Prognostic Indicator in Early-Stage Breast Carcinoma

1992 • 1,799 citations

Pathological prognostic factors in breast cancer

1999 • 1,676 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Sentinel lymphadenectomy in breast cancer.

1997 • 1,117 citations

Prognostic Factors in Breast Cancer

2000 • 1,068 citations

Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999.

2000 • 1,034 citations

Computer Program to Assist in Making Decisions About Adjuvant Therapy for Women With Early Breast Cancer

2001 • 1,007 citations

Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

2000 • 927 citations

2000 Update of Recommendations for the Use of Tumor Markers in Breast and Colorectal Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology*

2001 • 882 citations

THE RESULTS OF OPERATIONS FOR THE CURE OF CANCER OF THE BREAST PERFORMED AT THE JOHNS HOPKINS HOSPITAL FROM JUNE, 1889, TO JANUARY, 1894

1894 • 879 citations

Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials

2000 • 833 citations

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.

1997 • 811 citations

Tumor Marker Utility Grading System: a Framework to Evaluate Clinical Utility of Tumor Markers

1996 • 749 citations

Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

1998 • 602 citations

Statistical aspects of prognostic factor studies in oncology

1994 • 583 citations

Ovarian ablation in early breast cancer: overview of the randomised trials

1996 • 551 citations

Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

1997 • 503 citations

Micrometastatic Breast Cancer Cells in Bone Marrow at Primary Surgery: Prognostic Value in Comparison With Nodal Status

1996 • 491 citations

Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.

1995 • 477 citations

Randomized Adjuvant Chemotherapy Trial in High-Risk, Lymph Node-Negative Breast Cancer Patients Identified by Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1

2001 • 442 citations

Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06.

1988 • 415 citations

The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients.

2000 • 414 citations

Prognostic Factors in Breast Cancer.

1969 • 360 citations

Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years.

1989 • 357 citations

Clinical practice guidelines for the use of tumor markers in breast and colorectal cancer. Adopted on May 17, 1996 by the American Society of Clinical Oncology.

1996 • 343 citations

How To Use Prognostic Factors in Axillary Node-Negative Breast Cancer Patients

1990 • 323 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis

1999 • 315 citations

Quality of life and preferences for treatment following systemic adjuvant therapy for early-stage breast cancer.

1998 • 303 citations

When Is a Tumor Marker Ready for Prime Time? A Case Study of c-erbB-2 as a Predictive Factor in Breast Cancer

2001 • 302 citations

Factors influencing prognosis in node-negative breast carcinoma: analysis of 767 T1N0M0/T2N0M0 patients with long-term follow-up.

1993 • 293 citations

Prognostic Factors and Treatment Decisions in Axillary-Node-Negative Breast Cancer

1992 • 277 citations

The importance of histologic grade in long-term prognosis of breast cancer: a study of 1,010 patients, uniformly treated at the Institut Gustave-Roussy.

1987 • 269 citations

Methodological challenges in the evaluation of prognostic factors in breast cancer

1998 • 268 citations

Prognostic Factors and Therapeutic Decisions in Axillary Node-Negative Breast Cancer

1993 • 265 citations

American Joint Committee on Cancer Prognostic Factors Consensus Conference

1999 • 253 citations

Evaluating the Potential Usefulness of New Prognostic and Predictive Indicators on Node-Negative Breast Cancer Patients

1993 • 250 citations

Cyclin D1 in Breast Cancer

1998 • 241 citations

Survey of breast cancer patients concerning their knowledge and expectations of adjuvant therapy.

1998 • 241 citations

Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

2000 • 237 citations

Time-dependence of hazard ratios for prognostic factors in primary breast cancer

1998 • 229 citations

Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated.

1998 • 228 citations

Markers of tumor angiogenesis and proteolysis independently define high- and low-risk subsets of node-negative breast cancer patients.

1998 • 220 citations

Osteopontin expression in a group of lymph node negative breast cancer patients

1998 • 216 citations

DNA methylation in breast cancer.

2001 • 210 citations

Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases.

1997 • 207 citations

Epithelial Cells in Bone Marrow of Breast Cancer Patients at Time of Primary Surgery: Clinical Outcome During Long-Term Follow-Up

2001 • 203 citations

Assessing the clinical impact of prognostic factors: When is "statistically significant" clinically useful?

1998 • 191 citations

Natural history of node-negative breast cancer: a study of 826 patients with long-term follow-up.

1995 • 185 citations

Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

2000 • 177 citations

Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin.

2000 • 170 citations

1997 update of recommendations for the use of tumor markers in breast and colorectal cancer. Adopted on November 7, 1997 by the American Society of Clinical Oncology.

1998 • 166 citations

Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer

2013 • 153 citations

The loss of E-cadherin, α- and β-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer

2001 • 144 citations

Comparison of Mitotic Index, In Vitro Bromodeoxyuridine Labeling, and MIB-1 Assays to Quantitate Proliferation in Breast Cancer

1999 • 141 citations

Histologic Grading of Breast Cancer: Linkage of Patient Outcome with Level of Pathologist Agreement

2000 • 137 citations

American Joint Committee on Cancer Prognostic Factors Consensus Conference

1999 • 133 citations

Interobserver reproducibility of histopathological features in stage II breast cancer

1985 • 126 citations

High levels of TIMP-2 correlate with adverse prognosis in breast cancer

2000 • 123 citations

Clinical significance of determination of surrogate markers of angiogenesis in breast cancer

2001 • 123 citations

Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer

2002 • 121 citations

INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis.

2000 • 119 citations

Factors predicting treatment responsiveness and prognosis in node-negative breast cancer. The International (Ludwig) Breast Cancer Study Group.

1992 • 116 citations

Relationship between cathepsin-D content and disease-free survival in node-negative breast cancer patients: a meta-analysis

1997 • 114 citations

Prognostic value of Ki-67 compared to S-phase fraction in axillary node-negative breast cancer.

1996 • 112 citations

New prognostic factors for breast cancer recurrence

2001 • 112 citations

The urokinase plasminogen activator system as a target for prognostic studies in breast cancer

1998 • 94 citations

S-phase fraction and breast cancer - a decade of experience

1998 • 93 citations

Cathepsin D and breast cancer

1996 • 86 citations

Cyclin DI amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis.

1996 • 81 citations

Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers.

1997 • 73 citations

Individual characterisation of the metastatic capacity of human breast carcinoma

2000 • 58 citations

Ovarian ablation in early breast cancer: overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

1996 • 57 citations

Status of breast cancer prognostication based on histopathologic data.

1994 • 53 citations

Relation of tumor size, lymph node status, and survival in 24,740 breast cancer cases

1989 • 52 citations

The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer.

1998 • 50 citations

Adjuvant chemotherapy for breast cancer: discordance between physicians' perception of benefit and the results of clinical trials.

1994 • 48 citations

Prognostic and predictive value of thymidine labelling index in breast cancer

1998 • 35 citations

Immunohistologic evaluation of invasion-associated proteases in breast carcinoma.

1993 • 35 citations

Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer

1999 • 34 citations

Allelic loss at 1p34-36 predicts poor prognosis in node-negative breast cancer.

2000 • 28 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 27 citations

Association of Angiogenesis and Disease Outcome in Node-Positive Breast Cancer Patients Treated With Adjuvant Cyclophosphamide, Doxorubicin, and Fluorouracil: A Cancer and Leukemia Group B Correlative Science Study From Protocols 8541/8869

2002 • 24 citations

Detection and Significance of Occult Axillary Metastatic Disease in Breast Cancer Patients

1999 • 22 citations

Time-dependence of hazard ratios for prognostic factors in primary breast cancer

1998 • 18 citations

Enhanced prediction of breast cancer prognosis by evaluating expression of p53 and prostate-specific antigen in combination

1999 • 17 citations

Heterogeneity in Li-Fraumeni families: p53 mutation analysis and immunohistochemical staining.

1995 • 16 citations

Methodological challenges in the evaluation of prognostic factors in breast cancer

1998 • 14 citations

Lack of prognostic value of cathepsin D levels for predicting short term outcomes of breast cancer patients

1997 • 13 citations

Association of Angiogenesis and Disease Outcome in Node-Positive Breast Cancer Patients Treated With Adjuvant Cyclophosphamide, Doxorubicin, and Fluorouracil: A Cancer and Leukemia Group B Correlative Science Study From Protocols 8541/8869

2002 • 13 citations

Prognostic variables in node-negative and node-positive breast cancer — editorial

1998 • 12 citations

The relationship between NM23, angiogenesis, and the metastatic proclivity of node-negative breast cancer

1998 • 12 citations

The urokinase plasminogen activator system as a target for prognostic studies in breast cancer

1998 • 10 citations

Osteopontin expression in a group of lymph node negative breast cancer patients

1998 • 10 citations

S-phase fraction and breast cancer — a decade of experience

1998 • 6 citations

Prognostic and predictive value of thymidine labelling index in breast cancer

1998 • 4 citations

Allelic loss at 1p34, 13q12, 17p13.3, and 17q21.1 correlates with poor postoperative prognosis in breast cancer

1999 • 1 citations

Cited By (0)

Loading...